Differential expression of haptoglobin isoforms in chronic active hepatitis, cirrhosis and HCC related to HBV infection

  • Authors:
    • Jamal Sarvari
    • Zahra Mojtahedi
    • Yasuhiro Kuramitsu
    • Seyed-Ali Malek‑Hosseini
    • Mahmoud Shamsi Shahrabadi
    • Abbas Ghaderi
    • Kazuyuki Nakamura
  • View Affiliations

  • Published online on: May 31, 2011     https://doi.org/10.3892/ol.2011.321
  • Pages: 871-877
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The three main complications of hepatitis B virus (HBV) infection are chronic active hepatitis (CAH), liver cirrhosis, and hepatocellular carcinoma (HCC). The aim of this study was to identify differentially expressed serum proteins among the three liver complications in patients with HBV infection. Differentially expressed proteins have been shown to be potential biomarkers for disease diagnosis, prognosis and therapy guidance. Two-dimensional polyacrylamid gel electrophoresis (2DE) combined with liquid chromatography tandem mass spectrometry (LC-MS/MS) was performed on sera from CAH, cirrhosis and HCC patients with HBV infection, as well as those obtained from healthy individuals. Of 54 differentially expressed (≥1.5-fold and p<0.05) protein spots, 35 spots were identified by LC-MS/MS. The identified spots correlated to 13 proteins. The proteins included haptoglobolin α-2 and β isoforms, haptoglobin cleaved β isoforms, retinol-binding protein, transthyretin, ficolin, leucine-rich-α-2-glycoprotein, α-1-antitrypsin and clusterin. Of particular interest is the significant increase of haptoglobin α-2 isoforms in HCC patients compared to cirrhosis ones. In contrast, a significant decrease of the isoforms was noted among cirrhosis patients.

Related Articles

Journal Cover

September-October 2011
Volume 2 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Sarvari J, Mojtahedi Z, Kuramitsu Y, Malek‑Hosseini S, Shamsi Shahrabadi M, Ghaderi A and Nakamura K: Differential expression of haptoglobin isoforms in chronic active hepatitis, cirrhosis and HCC related to HBV infection. Oncol Lett 2: 871-877, 2011
APA
Sarvari, J., Mojtahedi, Z., Kuramitsu, Y., Malek‑Hosseini, S., Shamsi Shahrabadi, M., Ghaderi, A., & Nakamura, K. (2011). Differential expression of haptoglobin isoforms in chronic active hepatitis, cirrhosis and HCC related to HBV infection. Oncology Letters, 2, 871-877. https://doi.org/10.3892/ol.2011.321
MLA
Sarvari, J., Mojtahedi, Z., Kuramitsu, Y., Malek‑Hosseini, S., Shamsi Shahrabadi, M., Ghaderi, A., Nakamura, K."Differential expression of haptoglobin isoforms in chronic active hepatitis, cirrhosis and HCC related to HBV infection". Oncology Letters 2.5 (2011): 871-877.
Chicago
Sarvari, J., Mojtahedi, Z., Kuramitsu, Y., Malek‑Hosseini, S., Shamsi Shahrabadi, M., Ghaderi, A., Nakamura, K."Differential expression of haptoglobin isoforms in chronic active hepatitis, cirrhosis and HCC related to HBV infection". Oncology Letters 2, no. 5 (2011): 871-877. https://doi.org/10.3892/ol.2011.321