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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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September-October 2011 Volume 2 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Differential expression of haptoglobin isoforms in chronic active hepatitis, cirrhosis and HCC related to HBV infection

  • Authors:
    • Jamal Sarvari
    • Zahra Mojtahedi
    • Yasuhiro Kuramitsu
    • Seyed-Ali Malek‑Hosseini
    • Mahmoud Shamsi Shahrabadi
    • Abbas Ghaderi
    • Kazuyuki Nakamura

  • View Affiliations / Copyright

    Affiliations: Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran, Department of Biochemistry and Functional Proteomics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan, Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, Department of Virology, Tehran University of Medical Sciences, Hemat Highway, Tehran 1449614535, Iran
  • Pages: 871-877
    |
    Published online on: May 31, 2011
       https://doi.org/10.3892/ol.2011.321
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Abstract

The three main complications of hepatitis B virus (HBV) infection are chronic active hepatitis (CAH), liver cirrhosis, and hepatocellular carcinoma (HCC). The aim of this study was to identify differentially expressed serum proteins among the three liver complications in patients with HBV infection. Differentially expressed proteins have been shown to be potential biomarkers for disease diagnosis, prognosis and therapy guidance. Two-dimensional polyacrylamid gel electrophoresis (2DE) combined with liquid chromatography tandem mass spectrometry (LC-MS/MS) was performed on sera from CAH, cirrhosis and HCC patients with HBV infection, as well as those obtained from healthy individuals. Of 54 differentially expressed (≥1.5-fold and p<0.05) protein spots, 35 spots were identified by LC-MS/MS. The identified spots correlated to 13 proteins. The proteins included haptoglobolin α-2 and β isoforms, haptoglobin cleaved β isoforms, retinol-binding protein, transthyretin, ficolin, leucine-rich-α-2-glycoprotein, α-1-antitrypsin and clusterin. Of particular interest is the significant increase of haptoglobin α-2 isoforms in HCC patients compared to cirrhosis ones. In contrast, a significant decrease of the isoforms was noted among cirrhosis patients.

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Copy and paste a formatted citation
Spandidos Publications style
Sarvari J, Mojtahedi Z, Kuramitsu Y, Malek‑Hosseini S, Shamsi Shahrabadi M, Ghaderi A and Nakamura K: Differential expression of haptoglobin isoforms in chronic active hepatitis, cirrhosis and HCC related to HBV infection. Oncol Lett 2: 871-877, 2011.
APA
Sarvari, J., Mojtahedi, Z., Kuramitsu, Y., Malek‑Hosseini, S., Shamsi Shahrabadi, M., Ghaderi, A., & Nakamura, K. (2011). Differential expression of haptoglobin isoforms in chronic active hepatitis, cirrhosis and HCC related to HBV infection. Oncology Letters, 2, 871-877. https://doi.org/10.3892/ol.2011.321
MLA
Sarvari, J., Mojtahedi, Z., Kuramitsu, Y., Malek‑Hosseini, S., Shamsi Shahrabadi, M., Ghaderi, A., Nakamura, K."Differential expression of haptoglobin isoforms in chronic active hepatitis, cirrhosis and HCC related to HBV infection". Oncology Letters 2.5 (2011): 871-877.
Chicago
Sarvari, J., Mojtahedi, Z., Kuramitsu, Y., Malek‑Hosseini, S., Shamsi Shahrabadi, M., Ghaderi, A., Nakamura, K."Differential expression of haptoglobin isoforms in chronic active hepatitis, cirrhosis and HCC related to HBV infection". Oncology Letters 2, no. 5 (2011): 871-877. https://doi.org/10.3892/ol.2011.321
Copy and paste a formatted citation
x
Spandidos Publications style
Sarvari J, Mojtahedi Z, Kuramitsu Y, Malek‑Hosseini S, Shamsi Shahrabadi M, Ghaderi A and Nakamura K: Differential expression of haptoglobin isoforms in chronic active hepatitis, cirrhosis and HCC related to HBV infection. Oncol Lett 2: 871-877, 2011.
APA
Sarvari, J., Mojtahedi, Z., Kuramitsu, Y., Malek‑Hosseini, S., Shamsi Shahrabadi, M., Ghaderi, A., & Nakamura, K. (2011). Differential expression of haptoglobin isoforms in chronic active hepatitis, cirrhosis and HCC related to HBV infection. Oncology Letters, 2, 871-877. https://doi.org/10.3892/ol.2011.321
MLA
Sarvari, J., Mojtahedi, Z., Kuramitsu, Y., Malek‑Hosseini, S., Shamsi Shahrabadi, M., Ghaderi, A., Nakamura, K."Differential expression of haptoglobin isoforms in chronic active hepatitis, cirrhosis and HCC related to HBV infection". Oncology Letters 2.5 (2011): 871-877.
Chicago
Sarvari, J., Mojtahedi, Z., Kuramitsu, Y., Malek‑Hosseini, S., Shamsi Shahrabadi, M., Ghaderi, A., Nakamura, K."Differential expression of haptoglobin isoforms in chronic active hepatitis, cirrhosis and HCC related to HBV infection". Oncology Letters 2, no. 5 (2011): 871-877. https://doi.org/10.3892/ol.2011.321
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