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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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September-October 2011 Volume 2 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

The optimal age for performing surgery on patients with MEN 2B syndrome

  • Authors:
    • C. Gómez I Gavara
    • J. L. Ponce Marco
    • T. Belda Ibañez
    • A. Boscà Robledo
    • C. Sebastian Pastor
    • R. Navarro Milla
    • M. Caballero Soto
    • M. Meseguer Anastasio

  • View Affiliations / Copyright

    Affiliations: Department of Endocrine Surgery, La Fe University Hospital, 46009 Valencia, Spain
  • Pages: 929-930
    |
    Published online on: June 29, 2011
       https://doi.org/10.3892/ol.2011.332
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Abstract

Multiple endocrine neoplasia (MEN) syndromes are characterized by the association of various endocrine neoplasias. Prophylactic thyroidectomy is the treatment of choice for patients with RET gene mutations. The age at which patients undergo prophylactic thyroidectomy may vary depending on the position of the RET gene codon. In cases of MEN 2B, when the mutation is carried in codons 883, 918 or 922, prophylactic thyroidectomy is performed prior to 6 months of age, due to the increased aggressiveness of these heterozygosities, which are capable of determining the onset of medullary cancer during the first months of life. We present two heterozygous twin patients with MEN 2B syndrome who were born 32 weeks premature, and who underwent prophylactic thyroidectomy at 7 months of age. The patients were carriers of the mutation at codon 918. We suggested the early surgery at 7 months as, due to their prematurity, the patients were required to gain weight to improve their condition prior to surgery. The two patients had medullary thyroid carcinoma without lymph node involvement. In conclusion, for a truly prophylactic thyroidectomy, such patients should undergo surgery within the first month of life, particularly if these patients are carriers of the mutation in codons 883, 918 or 922.

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Copy and paste a formatted citation
Spandidos Publications style
Gómez I Gavara C, Ponce Marco JL, Belda Ibañez T, Boscà Robledo A, Sebastian Pastor C, Navarro Milla R, Caballero Soto M and Meseguer Anastasio M: The optimal age for performing surgery on patients with MEN 2B syndrome. Oncol Lett 2: 929-930, 2011.
APA
Gómez I Gavara, C., Ponce Marco, J.L., Belda Ibañez, T., Boscà Robledo, A., Sebastian Pastor, C., Navarro Milla, R. ... Meseguer Anastasio, M. (2011). The optimal age for performing surgery on patients with MEN 2B syndrome. Oncology Letters, 2, 929-930. https://doi.org/10.3892/ol.2011.332
MLA
Gómez I Gavara, C., Ponce Marco, J. L., Belda Ibañez, T., Boscà Robledo, A., Sebastian Pastor, C., Navarro Milla, R., Caballero Soto, M., Meseguer Anastasio, M."The optimal age for performing surgery on patients with MEN 2B syndrome". Oncology Letters 2.5 (2011): 929-930.
Chicago
Gómez I Gavara, C., Ponce Marco, J. L., Belda Ibañez, T., Boscà Robledo, A., Sebastian Pastor, C., Navarro Milla, R., Caballero Soto, M., Meseguer Anastasio, M."The optimal age for performing surgery on patients with MEN 2B syndrome". Oncology Letters 2, no. 5 (2011): 929-930. https://doi.org/10.3892/ol.2011.332
Copy and paste a formatted citation
x
Spandidos Publications style
Gómez I Gavara C, Ponce Marco JL, Belda Ibañez T, Boscà Robledo A, Sebastian Pastor C, Navarro Milla R, Caballero Soto M and Meseguer Anastasio M: The optimal age for performing surgery on patients with MEN 2B syndrome. Oncol Lett 2: 929-930, 2011.
APA
Gómez I Gavara, C., Ponce Marco, J.L., Belda Ibañez, T., Boscà Robledo, A., Sebastian Pastor, C., Navarro Milla, R. ... Meseguer Anastasio, M. (2011). The optimal age for performing surgery on patients with MEN 2B syndrome. Oncology Letters, 2, 929-930. https://doi.org/10.3892/ol.2011.332
MLA
Gómez I Gavara, C., Ponce Marco, J. L., Belda Ibañez, T., Boscà Robledo, A., Sebastian Pastor, C., Navarro Milla, R., Caballero Soto, M., Meseguer Anastasio, M."The optimal age for performing surgery on patients with MEN 2B syndrome". Oncology Letters 2.5 (2011): 929-930.
Chicago
Gómez I Gavara, C., Ponce Marco, J. L., Belda Ibañez, T., Boscà Robledo, A., Sebastian Pastor, C., Navarro Milla, R., Caballero Soto, M., Meseguer Anastasio, M."The optimal age for performing surgery on patients with MEN 2B syndrome". Oncology Letters 2, no. 5 (2011): 929-930. https://doi.org/10.3892/ol.2011.332
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