Extragastrointestinal stromal tumor originating from the vulva

  • Authors:
    • Takeshi Fukuda
    • Toshiyuki Sumi
    • Yusuke Nakano
    • Masanari Morishita
    • Hiroyuki Nobeyama
    • Hiroyuki Yoshida
    • Yoshinari Matsumoto
    • Tomoyo Yasui
    • Ken-ichi Honda
    • Osamu Ishiko
  • View Affiliations

  • Published online on: July 5, 2011     https://doi.org/10.3892/ol.2011.343
  • Pages: 797-799
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Abstract

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. They have gain-of-function mutations of the c-kit receptor tyrosine kinase gene and have been suggested to originate from the interstitial cells of Cajal. A small percentage of GISTs form extragastrointestinal masses. We report a rare case of a GIST originating from the vulva. A 55-year-old woman presented with a vulvar tumor. The tumor was initially diagnosed as a leiomyosarcoma following the first resection. Following a second recurrence the patient was administered chemotherapy. A third recurrence occurred and the patient underwent a third resection. Histology revealed that a bundle of fibrous tumor cells had invaded the connected tissue and muscular coat, and some spindle-shaped and blunt-ended nuclei were detected. Furthermore, immunohistochemical evaluation revealed that the tumor cells exhibited strong and diffuse staining for c-kit and CD34. The recurrent tumor was diagnosed as a GIST and a reevaluation of the original specimens also revealed a GIST. The patient was treated with imatinib, and is currently healthy with no evidence of recurrence at 20 months after the last surgery.

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September-October 2011
Volume 2 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Fukuda T, Sumi T, Nakano Y, Morishita M, Nobeyama H, Yoshida H, Matsumoto Y, Yasui T, Honda K, Ishiko O, Ishiko O, et al: Extragastrointestinal stromal tumor originating from the vulva. Oncol Lett 2: 797-799, 2011
APA
Fukuda, T., Sumi, T., Nakano, Y., Morishita, M., Nobeyama, H., Yoshida, H. ... Ishiko, O. (2011). Extragastrointestinal stromal tumor originating from the vulva. Oncology Letters, 2, 797-799. https://doi.org/10.3892/ol.2011.343
MLA
Fukuda, T., Sumi, T., Nakano, Y., Morishita, M., Nobeyama, H., Yoshida, H., Matsumoto, Y., Yasui, T., Honda, K., Ishiko, O."Extragastrointestinal stromal tumor originating from the vulva". Oncology Letters 2.5 (2011): 797-799.
Chicago
Fukuda, T., Sumi, T., Nakano, Y., Morishita, M., Nobeyama, H., Yoshida, H., Matsumoto, Y., Yasui, T., Honda, K., Ishiko, O."Extragastrointestinal stromal tumor originating from the vulva". Oncology Letters 2, no. 5 (2011): 797-799. https://doi.org/10.3892/ol.2011.343