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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

A polymorphism in the nuclear receptor coactivator 7 gene and breast cancer susceptibility

  • Authors:
    • Julia Süllner
    • Claus Lattrich
    • Julia Häring
    • Regina Görse
    • Olaf Ortmann
    • Oliver Treeck
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, University Medical Center Regensburg, Regensburg, Germany
  • Pages: 131-134
    |
    Published online on: September 16, 2011
       https://doi.org/10.3892/ol.2011.421
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Abstract

The nuclear receptor coactivator 7 (NCoA7) gene codes for an estrogen receptor-associated protein that plays a significant role in the cellular response to estrogens. Given that NCoA7 is expressed in the mammary gland, alterations in this gene may affect breast cancer risk. In this study, we compared the genotype and allele frequencies of the missense single nucleotide polymorphism (SNP) rs1567, located in the coding region of the NCoA7 gene and resulting in an amino acid exchange from asparagine to glutamine, in 305 women with sporadic breast cancer and 346 women without any malignancy. Statistical analysis of the observed frequencies did not reveal a significant difference between the cancer and control groups, nor did a comparison between histological breast cancer subgroups. In conclusion, the results of our phenotype-genotype association study indicate that NCoA7 SNP rs1567 does not affect breast cancer susceptibility.
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Copy and paste a formatted citation
Spandidos Publications style
Süllner J, Lattrich C, Häring J, Görse R, Ortmann O and Treeck O: A polymorphism in the nuclear receptor coactivator 7 gene and breast cancer susceptibility. Oncol Lett 3: 131-134, 2012.
APA
Süllner, J., Lattrich, C., Häring, J., Görse, R., Ortmann, O., & Treeck, O. (2012). A polymorphism in the nuclear receptor coactivator 7 gene and breast cancer susceptibility. Oncology Letters, 3, 131-134. https://doi.org/10.3892/ol.2011.421
MLA
Süllner, J., Lattrich, C., Häring, J., Görse, R., Ortmann, O., Treeck, O."A polymorphism in the nuclear receptor coactivator 7 gene and breast cancer susceptibility". Oncology Letters 3.1 (2012): 131-134.
Chicago
Süllner, J., Lattrich, C., Häring, J., Görse, R., Ortmann, O., Treeck, O."A polymorphism in the nuclear receptor coactivator 7 gene and breast cancer susceptibility". Oncology Letters 3, no. 1 (2012): 131-134. https://doi.org/10.3892/ol.2011.421
Copy and paste a formatted citation
x
Spandidos Publications style
Süllner J, Lattrich C, Häring J, Görse R, Ortmann O and Treeck O: A polymorphism in the nuclear receptor coactivator 7 gene and breast cancer susceptibility. Oncol Lett 3: 131-134, 2012.
APA
Süllner, J., Lattrich, C., Häring, J., Görse, R., Ortmann, O., & Treeck, O. (2012). A polymorphism in the nuclear receptor coactivator 7 gene and breast cancer susceptibility. Oncology Letters, 3, 131-134. https://doi.org/10.3892/ol.2011.421
MLA
Süllner, J., Lattrich, C., Häring, J., Görse, R., Ortmann, O., Treeck, O."A polymorphism in the nuclear receptor coactivator 7 gene and breast cancer susceptibility". Oncology Letters 3.1 (2012): 131-134.
Chicago
Süllner, J., Lattrich, C., Häring, J., Görse, R., Ortmann, O., Treeck, O."A polymorphism in the nuclear receptor coactivator 7 gene and breast cancer susceptibility". Oncology Letters 3, no. 1 (2012): 131-134. https://doi.org/10.3892/ol.2011.421
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