Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
January 2012 Volume 3 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January 2012 Volume 3 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Foot sarcomas: Factors affecting oncological and functional outcomes

  • Authors:
    • Eiji Kozawa
    • Yoshihiro Nishida
    • Hiroatsu Nakashima
    • Satoshi  Tsukushi
    • Kazuhiro Toriyama
    • Yuzuru Kamei
    • Naoki Ishiguro
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedic Surgery, Nagoya University Graduate School and School of Medicine, Nagoya, Aichi 466-8550, Japan, Department of Orthopaedic Surgery, Aichi Cancer Center Aichi Hospital, Okazaki, Aichi 444-0011, Japan, Department of Plastic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan
  • Pages: 82-88
    |
    Published online on: September 22, 2011
       https://doi.org/10.3892/ol.2011.427
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Oncological and functional prognostic factors for patients with foot sarcomas have yet to be clarified. This study was undertaken to identify the prognostic factors for oncological and functional outcomes and the significance of adjuvant radiotherapy in achieving local control in patients with foot sarcomas. We reviewed 31 consecutive patients with soft tissue (24), and bone (7) sarcomas arising in the foot and analyzed the impact of patient characteristics on the functional and oncological outcomes. There were seven cases with clear cell or epithelioid sarcomas. Two of the 31 cases experienced local recurrence despite the fact that only two cases received adjuvant radiotherapy. Sixteen out of 18 cases of soft tissue sarcomas with limb salvage surgery underwent reconstructive procedures for soft tissue defects. Amputation required as a surgical treatment (p=0.002) was a poor prognostic factor. Larger size (p=0.029) and bone reconstruction (p=0.018) were poor prognostic factors for local recurrence-free survival, and amputation (p=0.001) and bone reconstruction (p=0.008) for metastasis-free survival in patients with soft tissue sarcomas. No significant factors were derived in patients with bone sarcomas. Larger size (p=0.021), amputation (p=0.016) and bone reconstruction (p=0.03) were poor prognostic factors affecting function in patients with soft tissue sarcomas, and hindfoot site (p=0.028) and amputation (p=0.028) were poor prognostic factors affecting function in patients with bone sarcomas. Surgery with a negative operative margin and reconstructive procedures achieved good local control and function. Patients that had tumors with larger size, necessitating amputation or bone reconstruction, required novel multimodal treatment in order to improve their outcomes.
View Figures
View References

1 

Chou LB, Ho YY and Malawer MM: Tumors of the foot and ankle: experience with 153 cases. Foot Ankle Int. 30:836–841. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Papagelopoulos PJ, Mavrogenis AF, Badekas A and Sim FH: Foot malignancies: a multidisciplinary approach. Foot Ankle Clin. 8:751–763. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Unni KK: General aspects and data on 10,135 cases. Dahlin’s Bone Tumors. 6th edition. Lippincott Williams & Wilkins; Philadelphia, PA: pp. 1–224. 2010

4 

Brennan MF: Diagnosis and management of soft tissue sarcoma. Martin Dunitz; London: 2002

5 

Cribb GL, Loo SCS and Dickinson I: Limb salvage for soft-tissue sarcomas of the foot and ankle. J Bone Joint Surg. 92:424–429. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Enneking WF, Dunham W, Gebhardt MC, Malawar M and Pritchard DJ: A system for the functional evaluation of reconstructive procedures after surgical treatment of tumors of the musculoskeletal system. Clin Orthop Relat Res. 286:241–246. 1993.PubMed/NCBI

7 

Fletcher C, Unni K and Mertens F; World Health Organization. Classification of Tumours Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press; Lyon: 2002

8 

Guillou L, Coindre JM, Bonichon F, et al: Comparative study of the National Cancer Institute and the French Federation of Cancer Centers Sarcoma Group grading systems in a population of 410 adult patients with soft tissue sarcoma. J Clin Oncol. 15:350–362. 1997.

9 

Greene FL, Page DL and Flemming FD: American Joint Committee on Cancer: Cancer Staging Manual (6th edition). Springer. New York, NY: 157–164. 2002.

10 

Arai E, Nishida Y, Tsukushi S, Wasa J and Ishiguro N: Clinical and treatment outcomes of planned and unplanned excisions of soft tissue sarcomas. Clin Orthop Relat Res. 11:3028–3034. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Giuliano AE and Eilber FR: The rationale for planned reoperation after unplanned total excision of soft-tissue sarcomas. J Clin Oncol. 10:1344–1348. 1985.PubMed/NCBI

12 

Schwab JH, Agarwal P, Boland PJ, Kennedy JG and Healey JH: Patellar complications following distal femoral replacement after bone tumor resection. J Bone Joint Surg Am. 88:2225–2230. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Kaplan EL and Meier P: Nonparametric-estimation from incomplete observations. J Am Stat Assoc. 53:457–481. 1958. View Article : Google Scholar

14 

Temple HT, Worman DS and Mnaymneh WA: Unplanned surgical excision of tumors of the foot and ankle. Cancer Control. 8:262–268. 2001.PubMed/NCBI

15 

Zeytoonjian T, Mankin HJ, Gebhardt MC and Hornicek FJ: Distal lower extremity sarcomas: frequency of occurrence and patient survival rate. Foot Ankle Int. 5:325–30. 2004.PubMed/NCBI

16 

Colterjohn NR, Davis AM, O’Sullivan B, Catton CN, Wunder JS and Bell RS: Functional outcome in limb-salvage surgery for soft tissue tumours of the foot and ankle. Sarcoma. 1:67–74. 1997. View Article : Google Scholar : PubMed/NCBI

17 

Selch MT, Kopald KH, Ferreiro GA, Mirra JM, Parker RG and Eilber FR: LIMB salvage therapy for soft-tissue sarcomas of the foot. Int J Radiat Oncol Biol Phys. 19:41–48. 1990. View Article : Google Scholar : PubMed/NCBI

18 

Thacker MM, Potter BK, Pitcher JD and Temple HT: Soft tissue sarcomas of the foot and ankle: impact of unplanned excision, limb salvage, and multimodality therapy. Foot Ankle Int. 29:690–698. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Talbert ML, Zagars GK, Sherman NE and Romsdahl MM: Conservative surgery and radiation-therapy for soft-tissue sarcoma of the wrist, hand, ankle, and foot. Cancer. 66:2482–2491. 1990. View Article : Google Scholar : PubMed/NCBI

20 

Murari TM, Callaghan JJ, Berrey BH and Sweet DE: Primary benign and malignant osseous neoplasms of the foot. Foot Ankle. 10:68–80. 1989. View Article : Google Scholar : PubMed/NCBI

21 

O’Sullivan B, Davis AM, Turcotte R, et al: Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial. Lancet. 359:2235–2241. 2002.PubMed/NCBI

22 

Refaat Y, Gunnoe J, Hornicek FJ and Mankin HJ: Comparison of quality of life after amputation or limb salvage. Clin Orthop Relat Res. 397:298–305. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Zahlten-Hinguranage A, Bernd L, Ewerbeck V and Sabo D: Equal quality of life after limb-sparing or ablative surgery for lower extremity sarcomas. Br J Cancer. 6:1012–1014. 2004.PubMed/NCBI

24 

Weiss SW and Goldblum JR: Enzinger and Weiss’s soft tissue tumors. 4th edition. Mosby; St. Louis, MO: pp. 1191–1203. 2001

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kozawa E, Nishida Y, Nakashima H, Tsukushi S, Toriyama K, Kamei Y and Ishiguro N: Foot sarcomas: Factors affecting oncological and functional outcomes. Oncol Lett 3: 82-88, 2012.
APA
Kozawa, E., Nishida, Y., Nakashima, H., Tsukushi, S., Toriyama, K., Kamei, Y., & Ishiguro, N. (2012). Foot sarcomas: Factors affecting oncological and functional outcomes. Oncology Letters, 3, 82-88. https://doi.org/10.3892/ol.2011.427
MLA
Kozawa, E., Nishida, Y., Nakashima, H., Tsukushi, S., Toriyama, K., Kamei, Y., Ishiguro, N."Foot sarcomas: Factors affecting oncological and functional outcomes". Oncology Letters 3.1 (2012): 82-88.
Chicago
Kozawa, E., Nishida, Y., Nakashima, H., Tsukushi, S., Toriyama, K., Kamei, Y., Ishiguro, N."Foot sarcomas: Factors affecting oncological and functional outcomes". Oncology Letters 3, no. 1 (2012): 82-88. https://doi.org/10.3892/ol.2011.427
Copy and paste a formatted citation
x
Spandidos Publications style
Kozawa E, Nishida Y, Nakashima H, Tsukushi S, Toriyama K, Kamei Y and Ishiguro N: Foot sarcomas: Factors affecting oncological and functional outcomes. Oncol Lett 3: 82-88, 2012.
APA
Kozawa, E., Nishida, Y., Nakashima, H., Tsukushi, S., Toriyama, K., Kamei, Y., & Ishiguro, N. (2012). Foot sarcomas: Factors affecting oncological and functional outcomes. Oncology Letters, 3, 82-88. https://doi.org/10.3892/ol.2011.427
MLA
Kozawa, E., Nishida, Y., Nakashima, H., Tsukushi, S., Toriyama, K., Kamei, Y., Ishiguro, N."Foot sarcomas: Factors affecting oncological and functional outcomes". Oncology Letters 3.1 (2012): 82-88.
Chicago
Kozawa, E., Nishida, Y., Nakashima, H., Tsukushi, S., Toriyama, K., Kamei, Y., Ishiguro, N."Foot sarcomas: Factors affecting oncological and functional outcomes". Oncology Letters 3, no. 1 (2012): 82-88. https://doi.org/10.3892/ol.2011.427
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team