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Article

A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer

  • Authors:
    • Lixin Wang
    • Daoqiang Zhang
    • Changwen Zhang
    • Shuping Zhang
    • Zhe Wang
    • Chen Qu
    • Sijin Liu
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, P.R. China
  • Pages: 119-124
    |
    Published online on: September 28, 2011
       https://doi.org/10.3892/ol.2011.431
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Abstract

microRNAs (miRNAs) are involved in controlling tumor behaviors either as oncogenes or tumor suppressors. To elucidate the role of miRNAs in the regulation of tumor initiation, we delineated the microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer. A group of miRNAs were differentially expressed in MDA-MB‑231 and SUM1315 cells (with a high proportion of breast cancer tumor‑initiating cells, CD44+CD24-/low subpopulation) compared to MCF-7 cells (only a small proportion of CD44+CD24-/low cells). Among the differentially expressed miRNAs common to MDA-MB‑231 and SUM1315, approximately 46% of them are suggested to regulate the 'stemness' of stem cells or progenitor cells. Taken together, these findings suggested that miRNAs contribute to the maintenance of tumor‑initiating properties and indicate the potential value of the miRNA expression signature in characterizing or predicting the features (including metastasis) of breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Wang L, Zhang D, Zhang C, Zhang S, Wang Z, Qu C and Liu S: A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer. Oncol Lett 3: 119-124, 2012.
APA
Wang, L., Zhang, D., Zhang, C., Zhang, S., Wang, Z., Qu, C., & Liu, S. (2012). A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer. Oncology Letters, 3, 119-124. https://doi.org/10.3892/ol.2011.431
MLA
Wang, L., Zhang, D., Zhang, C., Zhang, S., Wang, Z., Qu, C., Liu, S."A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer". Oncology Letters 3.1 (2012): 119-124.
Chicago
Wang, L., Zhang, D., Zhang, C., Zhang, S., Wang, Z., Qu, C., Liu, S."A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer". Oncology Letters 3, no. 1 (2012): 119-124. https://doi.org/10.3892/ol.2011.431
Copy and paste a formatted citation
x
Spandidos Publications style
Wang L, Zhang D, Zhang C, Zhang S, Wang Z, Qu C and Liu S: A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer. Oncol Lett 3: 119-124, 2012.
APA
Wang, L., Zhang, D., Zhang, C., Zhang, S., Wang, Z., Qu, C., & Liu, S. (2012). A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer. Oncology Letters, 3, 119-124. https://doi.org/10.3892/ol.2011.431
MLA
Wang, L., Zhang, D., Zhang, C., Zhang, S., Wang, Z., Qu, C., Liu, S."A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer". Oncology Letters 3.1 (2012): 119-124.
Chicago
Wang, L., Zhang, D., Zhang, C., Zhang, S., Wang, Z., Qu, C., Liu, S."A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer". Oncology Letters 3, no. 1 (2012): 119-124. https://doi.org/10.3892/ol.2011.431
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