Open Access

MicroRNA expression profiling of mature ovarian teratomas

  • Authors:
    • Ye Ding
    • Xiao-Yan Gu
    • Feng Xu
    • Xiao-Yan Shi
    • Da‑Zheng Yang
    • Jian Zhong
    • Su-Min Wang
  • View Affiliations

  • Published online on: October 12, 2011     https://doi.org/10.3892/ol.2011.438
  • Pages: 35-38
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Abstract

MicroRNAs (miRNAs) are a class of endogenous, small, non-coding RNAs that regulate gene expression by targeting mRNAs and inhibiting expression via translation repression or RNA degradation. Emerging evidence indicates that miRNAs play a crucial role in the pathogenesis of human diseases, including tumor development. We profiled the miRNA expression between mature ovarian teratoma samples and matched normal tissues using miRNA microarrays, followed by validation with quantitative RT-PCR (qRT-PCR). The most highly expressed miRNAs in mature ovarian teratoma tissues were miRNA-520a-5p, miRNA‑26b*, miRNA-421, miRNA‑492 and miRNA-555, with a 1.3- to 2.6-fold change, whereas the least expressed miRNAs were miRNA-142-3p, let-7a, miRNA-19a, miRNA‑34a, miRNA‑620, miRNA-934, miRNA-657, miRNA-720, miRNA-22, miRNA‑629 and miRNA-214, with a decreased level of 55-87% compared with normal tissues. The findings of the present study are the first to provide an altered miRNA profile for mature ovarian teratomas and differentially expressed miRNAs, which, if validated in future studies, may be essential in the pathogenesis of mature ovarian teratomas.
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January 2012
Volume 3 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Ding Y, Gu X, Xu F, Shi X, Yang DZ, Zhong J and Wang S: MicroRNA expression profiling of mature ovarian teratomas. Oncol Lett 3: 35-38, 2012
APA
Ding, Y., Gu, X., Xu, F., Shi, X., Yang, D., Zhong, J., & Wang, S. (2012). MicroRNA expression profiling of mature ovarian teratomas. Oncology Letters, 3, 35-38. https://doi.org/10.3892/ol.2011.438
MLA
Ding, Y., Gu, X., Xu, F., Shi, X., Yang, D., Zhong, J., Wang, S."MicroRNA expression profiling of mature ovarian teratomas". Oncology Letters 3.1 (2012): 35-38.
Chicago
Ding, Y., Gu, X., Xu, F., Shi, X., Yang, D., Zhong, J., Wang, S."MicroRNA expression profiling of mature ovarian teratomas". Oncology Letters 3, no. 1 (2012): 35-38. https://doi.org/10.3892/ol.2011.438