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January 2012 Volume 3 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

NY-ESO-1 expression in hepatocellular carcinoma: A potential new marker for early recurrence after surgery

  • Authors:
    • Heng Xu
    • Na Gu
    • Zhao-Bo Liu
    • Min Zheng
    • Fang Xiong
    • Si-Ying Wang
    • Ning Li
    • Jun Lu
  • View Affiliations / Copyright

    Affiliations: Tumor Biotherapy Ward of Beijing YouAn Hospital, Capital Medical University, Beijing 100069, P.R. China, Hangzhou High Throughput Drug Screening Center, SanDun, Hangzhou 310030, P.R. China, Department of Pathophysiology, Anhui Medical University, Hefei 230032, P.R. China
  • Pages: 39-44
    |
    Published online on: October 13, 2011
       https://doi.org/10.3892/ol.2011.441
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Abstract

NY-ESO-1 belongs to the cancer testis antigens (CTA) family, and is identified in a variety of tumors. Certain studies have demonstrated that NY-ESO-1 predicts tumor recurrence and treatment response. No reports are currently available regarding the correlation between NY-ESO-1 and the recurrence of hepatocellular carcinoma (HCC) following surgery. The purpose of the present study was to evaluate the association between NY-ESO-1 and relapse of HCC and to explore the possible mechanisms for this correlation. A total of 120 HCC patients were analyzed for the expression of NY-ESO-1 by immunohistochemistry (IHC). A stable NY-ESO-1 over-expressed HepG2 cell line (ESO-HepG2) was established to determine the biological effects of NY-ESO-1 on cell proliferation, cell cycle and migration by using the xCELLigence DP system, flow cytometry and xCELLigence SP system. NY-ESO-1 was positive in 28 of 120 (23.3%) HCC tumor tissues. NY-ESO-1 was not detectable in adjacent normal liver tissues. A close correlation was found between NY-ESO-1 expression and the recurrence of HCC following surgery (P=0.007). Kaplan-Meier analysis showed a shorter recurrence-free survival (RFS) for patients positive for NY-ESO-1 (log-rank test, P=0.003). The Cox regression model demonstrated that NY-ESO-1 expression was a significant independent predictor for the recurrence of HCC following curative surgery (P=0.022). Compared with HepG2 cells, ESO-HepG2 cells have increased migration but not proliferation ability. In conclusion, NY-ESO-1 expression is associated with worse HCC outcome following surgery, and the mechanism for this finding may be that NY-ESO-1 increases tumor cell migration.
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Copy and paste a formatted citation
Spandidos Publications style
Xu H, Gu N, Liu Z, Zheng M, Xiong F, Wang S, Li N and Lu J: NY-ESO-1 expression in hepatocellular carcinoma: A potential new marker for early recurrence after surgery. Oncol Lett 3: 39-44, 2012.
APA
Xu, H., Gu, N., Liu, Z., Zheng, M., Xiong, F., Wang, S. ... Lu, J. (2012). NY-ESO-1 expression in hepatocellular carcinoma: A potential new marker for early recurrence after surgery. Oncology Letters, 3, 39-44. https://doi.org/10.3892/ol.2011.441
MLA
Xu, H., Gu, N., Liu, Z., Zheng, M., Xiong, F., Wang, S., Li, N., Lu, J."NY-ESO-1 expression in hepatocellular carcinoma: A potential new marker for early recurrence after surgery". Oncology Letters 3.1 (2012): 39-44.
Chicago
Xu, H., Gu, N., Liu, Z., Zheng, M., Xiong, F., Wang, S., Li, N., Lu, J."NY-ESO-1 expression in hepatocellular carcinoma: A potential new marker for early recurrence after surgery". Oncology Letters 3, no. 1 (2012): 39-44. https://doi.org/10.3892/ol.2011.441
Copy and paste a formatted citation
x
Spandidos Publications style
Xu H, Gu N, Liu Z, Zheng M, Xiong F, Wang S, Li N and Lu J: NY-ESO-1 expression in hepatocellular carcinoma: A potential new marker for early recurrence after surgery. Oncol Lett 3: 39-44, 2012.
APA
Xu, H., Gu, N., Liu, Z., Zheng, M., Xiong, F., Wang, S. ... Lu, J. (2012). NY-ESO-1 expression in hepatocellular carcinoma: A potential new marker for early recurrence after surgery. Oncology Letters, 3, 39-44. https://doi.org/10.3892/ol.2011.441
MLA
Xu, H., Gu, N., Liu, Z., Zheng, M., Xiong, F., Wang, S., Li, N., Lu, J."NY-ESO-1 expression in hepatocellular carcinoma: A potential new marker for early recurrence after surgery". Oncology Letters 3.1 (2012): 39-44.
Chicago
Xu, H., Gu, N., Liu, Z., Zheng, M., Xiong, F., Wang, S., Li, N., Lu, J."NY-ESO-1 expression in hepatocellular carcinoma: A potential new marker for early recurrence after surgery". Oncology Letters 3, no. 1 (2012): 39-44. https://doi.org/10.3892/ol.2011.441
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