The adiponectin gene, ADIPOQ, and genetic susceptibility to colon cancer

Al-Harithy,Rowyda  N.; Al-Zahrani,Maryam  H.

doi:10.3892/ol.2011.443

The adiponectin gene, ADIPOQ, and genetic susceptibility to colon cancer

Authors:
- Rowyda N. Al-Harithy
- Maryam H. Al-Zahrani
View Affiliations

Affiliations: Department of Biochemistry, King Abdul Aziz University, Jeddah 21499, Saudi Arabia
Published online on: October 18, 2011 https://doi.org/10.3892/ol.2011.443
Pages: 176-180

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

In order to evaluate the contribution of polymorphisms of the adiponectin gene, ADIPOQ, to the risk of colon cancer, we conducted a case-control study of 60 colon cancer patients and 60 age, gender and ethnicity-matched controls in the Saudi population. We tested the hypothesis by analyzing the genotypes for two single nucleotide polymorphisms (SNPs), rs1501299 (G276T) and rs2241766 (T45G), in the ADIPOQ gene. In addition, the study was also designed to assess whether the two SNPs contribute to circulating adiponectin levels. We observed an increased risk of colon cancer associated with the 276T allele. The odds ratio (OR) was 2.64 [95% confidence interval (CI), 0.49-14.6]. The G allele at the T45G polymorphism was associated with a lower risk of colon cancer (OR=0.41; 95% CI, 0.19-0.86). Our results suggest that the risk of developing colon cancer may be partially explained by genetic polymorphisms in the ADIPOQ gene.

View Figures

View References

1	Ibrahim M, Zeeneldin A, El-Khodary T, Al-Gahmi A and Bin Sadiq B: Past present and future of colorectal cancer in the Kingdom of Saudi Arabia. Saudi J Gastroenterol. 14:178–182. 2008. View Article : Google Scholar : PubMed/NCBI
2	Aljebreen A: Clinico-pathological patterns of colorectal cancer in Saudi Arabia: Younger with an advanced stage presentation. Saudi J Gastroenterol. 13:84–87. 2007. View Article : Google Scholar : PubMed/NCBI
3	Scherer P, Williams S, Fogliano M, Baldini G and Lodish H: A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem. 270:26746–26749. 1995. View Article : Google Scholar : PubMed/NCBI
4	Maeda K, Okubo K, Shimomura I, et al: cDNA cloning and expression of a novel adipose specific collagen-like factOR=apM1 (adipose most abundant gene transcript 1). Biochem Biophys Res Commun. 221:286–289. 1996.
5	Kadowaki T and Yamauchi T: Adiponectin and adiponectin receptors. Endocr Rev. 26:439–451. 2005. View Article : Google Scholar : PubMed/NCBI
6	Hotta K, Funahashi T, Arita Y, et al: Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol. 20:1595–1599. 2000. View Article : Google Scholar : PubMed/NCBI
7	Weyer C, Funahashi T, Tanaka S, et al: Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab. 86:1930–1935. 2001. View Article : Google Scholar : PubMed/NCBI
8	Yamauchi T, Kamon J, Ito Y, et al: Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 423:762–769. 2003. View Article : Google Scholar : PubMed/NCBI
9	Kondo H, Shimomura I, Matsukawa Y, et al: Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome. Diabetes. 51:2325–2328. 2002. View Article : Google Scholar : PubMed/NCBI
10	Chandran M, Ciaraldi T, Phillips SA and Henry R: Adiponectin: more than just another fat cell hormone? Diabetes Care. 26:2442–2450. 2003. View Article : Google Scholar : PubMed/NCBI
11	Diez J and Iglesias P: The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol. 148:293–300. 2003. View Article : Google Scholar : PubMed/NCBI
12	Cruz M, García-Macedo R, García-Valerio Y, et al: Low adiponectin levels predict type 2 diabetes in Mexican children. Diabetes Care. 27:1451–1453. 2004. View Article : Google Scholar : PubMed/NCBI
13	Engeli S, Feldpausch M, Gorzelniak K, et al: Association between adiponectin and mediators of inflammation in obese women. Diabetes. 52:942–947. 2003. View Article : Google Scholar : PubMed/NCBI
14	Kazumi T, Kawaguchi A, Sakai K, Hirano T and Yoshino G: Young men with high-normal blood pressure have lower serum adiponectin, smaller LDL size, and higher elevated heart rate than those with optimal blood pressure. Diabetes Care. 25:971–976. 2002. View Article : Google Scholar
15	Ryo M, Nakamura T, Kihara S, et al: Adiponectin as a biomarker of the metabolic syndrome. Circ J. 68:975–981. 2004. View Article : Google Scholar : PubMed/NCBI
16	Ishikawa M, Kitayama J, Yamauchi T, et al: Adiponectin inhibits the growth and peritoneal metastasis of gastric cancer through its specific membrane receptors AdipoR1 and AdipoR2. Cancer Sci. 98:1120–1127. 2007. View Article : Google Scholar
17	Fukumoto J, Otake T, Tajima O, et al: Adiponectin and colorectal adenomas: Self Defense Forces Health Study. Cancer Sci. 99:781–786. 2008. View Article : Google Scholar : PubMed/NCBI
18	Kumor A, Daniel P, Pietruczuk M and Małecka-Panas E: Serum leptin, adiponectin, and resistin concentration in colorectal adenoma and carcinoma (CC) patients. Int J Colorectal Dis. 24:275–281. 2009. View Article : Google Scholar : PubMed/NCBI
19	Hara K, Boutin P, Mori Y, et al: Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes. 51:536–540. 2002. View Article : Google Scholar : PubMed/NCBI
20	Menzaghi C, Ercolino T, Di Paola R, et al: A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome. Diabetes. 51:2306–2312. 2002. View Article : Google Scholar : PubMed/NCBI
21	Menzaghi C, Ercolino T, Salvemini L, et al: Multigenic control of serum adiponectin levels: evidence for a role of the ADIPOQ gene and a locus on 14q13. Physiol Genomics. 19:170–174. 2004. View Article : Google Scholar : PubMed/NCBI
22	Berthier MT, Houde A, Cote M, et al: Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men. J Lipid Res. 46:237–244. 2005. View Article : Google Scholar : PubMed/NCBI
23	Pollin T, Tanner K, O’Connell J, et al: Linkage of plasma adiponectin levels to 3q27 explained by association with variation in the ADIPOQ gene. Diabetes. 54:268–274. 2005. View Article : Google Scholar : PubMed/NCBI
24	Qi L, Li T, Rimm E, et al: The +276 polymorphism of the APM1 gene, plasma adiponectin concentration, and cardiovascular risk in diabetic men. Diabetes. 54:1607–1610. 2005.
25	Melistas L, Mantzoros C, Kontogianni M, et al: Association of the +45T>G and +276G>T polymorphisms in the adiponectin gene with insulin resistance in non-diabetic Greek women. Eur J Endocrinol. 161:845–852. 2009.
26	Siitonen N, Pulkkinen L, Lindström J, et al: Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study. BMC Med Genet. 12:52011. View Article : Google Scholar
27	Jang Y, Lee J, Kim O, et al: The SNP276G>T polymorphism in the adiponectin (ACDC) gene is more strongly associated with insulin resistance and cardiovascular disease risk than SNP45T>G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin. Metabolism. 55:59–66. 2006.
28	Filippi E, Sentinelli F, Trischitta V, et al: Association of the human adiponectin gene and insulin resistance. Eur J Hum Genet. 12:199–205. 2004. View Article : Google Scholar : PubMed/NCBI
29	Ohashi K, Ouchi N, Kihara S, et al: Adiponectin I164 T mutation is associated with the metabolic syndrome and coronary artery disease. J Am Coll Cardiol. 43:1195–1200. 2004. View Article : Google Scholar : PubMed/NCBI
30	Vozarova de Courten B, Hanson R, et al: Common polymorphisms in the adiponectin gene ACDC are not associated with diabetes in Pima Indians. Diabetes. 54:284–289. 2005.PubMed/NCBI
31	Filippi E, Sentinelli F, Romeo S, et al: The adiponectin gene SNP+276G>T associates with early-onset coronary artery disease and with lower levels of adiponectin in younger coronary artery disease patients (age <or=50 years). J Mol Med (Berl). 83:711–719. 2005.
32	Woo J, Dolan L, Deka R, et al: Interactions between noncontiguous haplotypes in the adiponectin gene ACDC are associated with plasma adiponectin. Diabetes. 55:523–529. 2006. View Article : Google Scholar : PubMed/NCBI