Ten‑Eleven Translocation‑2 gene mutations: A potential new molecular marker in malignant gliomas (Review)

  • Authors:
    • Lei Yu
    • SongTao Qi
  • View Affiliations

  • Published online on: October 18, 2011     https://doi.org/10.3892/ol.2011.447
  • Pages: 7-10
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Abstract

Alterations of the Ten‑Eleven Translocation‑2 (TET2) gene in myeloid malignancies and isocitrate dehydrogenase (IDH) gene mutations in gliomas and myeloid malignancies have recently been identified using molecular, comparative genomic hybridization and single nucleotide polymorphism array techniques. The mutations of the TET2 gene have been shown to be mutually exclusive with IDH1/2 mutations in acute myeloid leukemia (AML) and evidence has been found to provide a biochemical basis for the mutual exclusivity of IDH1/2 and TET2 gene mutations. Based on mounting evidence, we aimed to investigate whether TET2 mutations may be identified as novel mutations in malignant gliomas without IDH1/2 mutations, and indicate their possible significance in gliomas.
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January 2012
Volume 3 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yu L and Yu L: Ten‑Eleven Translocation‑2 gene mutations: A potential new molecular marker in malignant gliomas (Review). Oncol Lett 3: 7-10, 2012
APA
Yu, L., & Yu, L. (2012). Ten‑Eleven Translocation‑2 gene mutations: A potential new molecular marker in malignant gliomas (Review). Oncology Letters, 3, 7-10. https://doi.org/10.3892/ol.2011.447
MLA
Yu, L., Qi, S."Ten‑Eleven Translocation‑2 gene mutations: A potential new molecular marker in malignant gliomas (Review)". Oncology Letters 3.1 (2012): 7-10.
Chicago
Yu, L., Qi, S."Ten‑Eleven Translocation‑2 gene mutations: A potential new molecular marker in malignant gliomas (Review)". Oncology Letters 3, no. 1 (2012): 7-10. https://doi.org/10.3892/ol.2011.447