Early clinical diagnosis of synchronous multiple primary lung cancer

Xue,XinYing; Xue,QingLiang; Wang,Na; Zhang,Lina; Guo,Lina; Li,Xinfu; Sun,Junping; Wang,Jianxin

doi:10.3892/ol.2011.452

January 2012 Volume 3 Issue 1

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

January 2012 Volume 3 Issue 1

Full Size Image

Article

Early clinical diagnosis of synchronous multiple primary lung cancer

Authors:
- XinYing Xue
- QingLiang Xue
- Na Wang
- Lina Zhang
- Lina Guo
- Xinfu Li
- Junping Sun
- Jianxin Wang
View Affiliations / Copyright

Affiliations: The Respiratory Diseases Department of the Chinese PLA General Hospital, Beijing 100853, P.R. China
Pages: 234-237
|
Published online on: October 19, 2011

https://doi.org/10.3892/ol.2011.452
Expand metrics +

Abstract

The diagnosis of synchronous multiple primary lung cancer (SMPLC) remains a formidable challenge. The aim of the present study was to identify useful clues for the clinical diagnosis of SMPLC, in particular for the early stages. The medical records of 10 patients diagnosed with SMPLC with different histological types were analyzed retrospectively. Chest computed tomography (CT) findings showed two pulmonary lesions in all patients. The two lesions displayed malignant characteristics of primary lung cancer. The levels of a number of tumor markers, including carcinoembryonic antigen, neuron‑specific enolase, cytokeratin fragment 21-1, squamous cell carcinoma and CA125 increased in 2 patients. Auxiliary examinations of other physical sites in these patients did not show signs of neoplasm metastasis. Two tumors were separately staged and appropriate treatment was carried out based on the revised stage, which provided more benefits for SMPLC patients. The diagnosis of SMPLC might be delayed or mistaken owing to its similarity to neoplasm metastasis. A high index of awareness is required for the early diagnosis of this disease. The malignant characteristics of primary lung cancer in various lesions may be valuable clues for the diagnosis of SMPLC. Alterations in the levels of tumor markers may be a poor diagnostic tool for the detection of SMPLC. Separate biopsies for different pulmonary masses should be performed for clinical staging as soon as possible and reasonable treatment based on the stage should also be selected.

View Figures

View References

1	Ferguson MK, DeMeester TR, DesLauriers J, et al: Diagnosis and management of synchronous lung cancer. J Thorac Cardiovasc Surg. 89:378–385. 1985.
2	Martini N and Melamed MR: Multiple primary lung cancers. J Thorac Cardiovasc Surg. 70:606–612. 1975.
3	Wang X, Christiani DC, Mark EJ, et al: Carcinogen exposure, p53 alteration, and K-ras mutation in synchronous multiple primary lung carcinoma. Cancer. 85:1734–1739. 1999. View Article : Google Scholar : PubMed/NCBI
4	Miura H, Nakajima N, Ikeda N, et al: Therapeutic strategy for secondary lung cancer. Kyobu Geka. 63:956–961. 2010.PubMed/NCBI
5	Van Rens MTM, Zanen P, de la Riviere AB, et al: Survival in synchronous versus single lung cancer: upstaging better reflects prognosis. Chest. 118:952–958. 2000.PubMed/NCBI
6	Lam S, MacAulay C and Palcic B: Detection and localization of early lung cancer by imaging techniques. Chest. 103:S12–S14. 1993. View Article : Google Scholar : PubMed/NCBI
7	Woolner LB, Fontana RS, Cortese DA, et al: Roentgenographically occult lung cancer: pathologic findings and frequency of multicentricity during a 10-year period. Mayo Clin Proc. 59:453–466. 1984.PubMed/NCBI
8	Morita T: Incidence, contents and change of autopsied multiple primary cancers of the lung based on the annual of the autopsy cases in Japan between 1958 and 1992. Haigan. 37:283–294. 1997. View Article : Google Scholar
9	Saito Y, Fujimura S, Sato M, et al: Recent advances in diagnosis and treatment of multiple primary lung cancers. Nippon Kyobu Rinsho. 52:95–101. 1993.
10	Matsuge S, Hosokawa Y, Sato K, et al: Surgical treatment for bilateral multiple lung cancers. Kyobu Geka. 53:89–94. 2000.
11	Niho S, Nishiwaki Y, Goto K, et al: Significance of serum pro-gastrin-releasing peptide as a predictor of relapse of small cell lung cancer: comparative evaluation with neuron-specific enolase and carcinoembryonic antigen. Lung Cancer. 27:159–167. 2000. View Article : Google Scholar : PubMed/NCBI
12	Shibayama T, Ueoka H, Nishii K, et al: Complementary roles of pro-gastrin-releasing peptide (ProGRP) and neuron specific enolase (NSE) in diagnosis and prognosis of small cell lung cancer (SCLC). Lung Cancer. 32:61–69. 2001. View Article : Google Scholar : PubMed/NCBI
13	Jorgensen LGM, Osterlind K, Genolla J, et al: Serum neuron-specific enolase (S-NSE) and the prognosis in small-cell lung cancer (SCLC): a combined multivariable analysis on data from nine centres. Br J Cancer. 74:463–467. 1996. View Article : Google Scholar : PubMed/NCBI
14	Molina R, Filella X and Auge JM: ProGRP: a new biomarker for small cell lung cancer. Clin Biochem. 37:505–511. 2004. View Article : Google Scholar : PubMed/NCBI
15	Stieber P, Dienemann H, Schalhorn A, et al: Pro-gastrin-releasing peptide (ProGRP) - a useful marker in small cell lung carcinomas. Anticancer Res. 19:2673–2678. 1999.PubMed/NCBI
16	Lamy PJ, Grenier J and Pujol JL: Pro-gastrin-releasing peptide, neuron specific enolase and chromogranin A as serum markers of small cell lung cancer. Lung Cancer. 29:197–203. 2000. View Article : Google Scholar : PubMed/NCBI
17	Goto K, Kodama T, Hojo F, et al: Clinicopathologic characteristics of patients with nonsmall cell lung carcinoma with elevated serum progastrin-releasing peptide levels. Cancer. 82:1056–1061. 1998. View Article : Google Scholar : PubMed/NCBI
18	Molina R, Auge JM, Bosch X, et al: Usefulness of serum tumor markers, including progastrin-releasing peptide, in patients with lung cancer: correlation with histology. Tumor Biol. 30:121–129. 2009. View Article : Google Scholar : PubMed/NCBI
19	Van Rens MTM, de la Riviere AB, Elbers HRJ, et al: Prognostic assessment of 2,361 patients who underwent pulmonary resection for non-small cell lung cancer stage I, II and IIIA. Chest. 117:374–379. 2000.PubMed/NCBI
20	Chang YL, Wu CT and Lee YC: Surgical treatment of synchronous multiple primary lung cancers: experience of 92 patients. J Thorac Cardiovasc Surg. 134:630–637. 2007. View Article : Google Scholar : PubMed/NCBI
21	Adebonojo SA, Moritz DM and Danby CA: The results of modern surgical therapy for multiple primary lung cancers. Chest. 112:693–701. 1997. View Article : Google Scholar : PubMed/NCBI
22	Tsunezuka Y, Matsumoto I, Tamura M, et al: The results of therapy for bilateral multiple primary lung cancers: 30 years experience in a single centre. Eur J Surg Oncol. 30:781–785. 2004.PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Early clinical diagnosis of synchronous multiple primary lung cancer

This article is mentioned in:

Abstract

Figure 1

Figure 2

Related Articles