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February 2012 Volume 3 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Presence of EGFR mutation in pathologically non-malignant specimens from computed tomography-guided lung needle biopsies

  • Authors:
    • Tsuyoshi Ueno
    • Junichi Soh
    • Takao Hiraki
    • Hiroaki Asano
    • Koichi  Ichimura
    • Kentaro  Shibamoto
    • Hideo Gobara
    • Susumu  Kanazawa
    • Shinichi Toyooka
    • Shinichiro Miyoshi
  • View Affiliations / Copyright

    Affiliations: Department of General Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan, Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan, Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan
  • Pages: 401-404
    |
    Published online on: November 3, 2011
       https://doi.org/10.3892/ol.2011.471
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Abstract

Activating mutations of the epidermal growth factor receptor (EGFR) gene are characteristic of non-small cell lung cancer (NSCLC). EGFR mutations were previously detected in histologically normal lung tissue around NSCLC tumors. Computed tomography-guided lung needle biopsy (CTNB) is an accurate and useful technique for the diagnosis of lung tumors. However, pathologically non-malignant cases occasionally become apparent following lung tumor resection. In this study, we determined the EGFR mutational status of lung tumors diagnosed as non-malignant in CTNB specimens, but diagnosed as NSCLC following surgical resection. Between 2000 and 2008, 1,109 CTNBs were performed at Okayama University Hospital. Among them, 15 cases were initially diagnosed as non-malignant by CTNB, but diagnosed as NSCLC following surgical resection as a result of a high likelihood of malignancy by clinical findings. Twelve paired DNAs of CTNB and corresponding resected specimens were available to examine the EGFR mutational status using a mutant-enriched PCR assay. EGFR mutations were detected in one out of 12 CTNB specimens and three of the corresponding resected tumors. This case harbored the same EGFR mutation in the CTNB specimen and resected tumor, but not in the distant corresponding non-malignant lung tissue. Our results indicated that the detection of EGFR mutations may therefore aid the diagnosis of NSCLC in pathologically non-malignant CTNB specimens.
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Copy and paste a formatted citation
Spandidos Publications style
Ueno T, Soh J, Hiraki T, Asano H, Ichimura K, Shibamoto K, Gobara H, Kanazawa S, Toyooka S, Miyoshi S, Miyoshi S, et al: Presence of EGFR mutation in pathologically non-malignant specimens from computed tomography-guided lung needle biopsies. Oncol Lett 3: 401-404, 2012.
APA
Ueno, T., Soh, J., Hiraki, T., Asano, H., Ichimura, K., Shibamoto, K. ... Miyoshi, S. (2012). Presence of EGFR mutation in pathologically non-malignant specimens from computed tomography-guided lung needle biopsies. Oncology Letters, 3, 401-404. https://doi.org/10.3892/ol.2011.471
MLA
Ueno, T., Soh, J., Hiraki, T., Asano, H., Ichimura, K., Shibamoto, K., Gobara, H., Kanazawa, S., Toyooka, S., Miyoshi, S."Presence of EGFR mutation in pathologically non-malignant specimens from computed tomography-guided lung needle biopsies". Oncology Letters 3.2 (2012): 401-404.
Chicago
Ueno, T., Soh, J., Hiraki, T., Asano, H., Ichimura, K., Shibamoto, K., Gobara, H., Kanazawa, S., Toyooka, S., Miyoshi, S."Presence of EGFR mutation in pathologically non-malignant specimens from computed tomography-guided lung needle biopsies". Oncology Letters 3, no. 2 (2012): 401-404. https://doi.org/10.3892/ol.2011.471
Copy and paste a formatted citation
x
Spandidos Publications style
Ueno T, Soh J, Hiraki T, Asano H, Ichimura K, Shibamoto K, Gobara H, Kanazawa S, Toyooka S, Miyoshi S, Miyoshi S, et al: Presence of EGFR mutation in pathologically non-malignant specimens from computed tomography-guided lung needle biopsies. Oncol Lett 3: 401-404, 2012.
APA
Ueno, T., Soh, J., Hiraki, T., Asano, H., Ichimura, K., Shibamoto, K. ... Miyoshi, S. (2012). Presence of EGFR mutation in pathologically non-malignant specimens from computed tomography-guided lung needle biopsies. Oncology Letters, 3, 401-404. https://doi.org/10.3892/ol.2011.471
MLA
Ueno, T., Soh, J., Hiraki, T., Asano, H., Ichimura, K., Shibamoto, K., Gobara, H., Kanazawa, S., Toyooka, S., Miyoshi, S."Presence of EGFR mutation in pathologically non-malignant specimens from computed tomography-guided lung needle biopsies". Oncology Letters 3.2 (2012): 401-404.
Chicago
Ueno, T., Soh, J., Hiraki, T., Asano, H., Ichimura, K., Shibamoto, K., Gobara, H., Kanazawa, S., Toyooka, S., Miyoshi, S."Presence of EGFR mutation in pathologically non-malignant specimens from computed tomography-guided lung needle biopsies". Oncology Letters 3, no. 2 (2012): 401-404. https://doi.org/10.3892/ol.2011.471
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