8-Hydroxy-2'-deoxyguanosine expression predicts hepatocellular carcinoma outcome

  • Authors:
    • Shengmian Li
    • Xiaoling Wang
    • Yijuan Wu
    • Huijing Zhang
    • Lan  Zhang
    • Cuiju Wang
    • Ruixing Zhang
    • Zhanjun Guo
  • View Affiliations

  • Published online on: November 10, 2011     https://doi.org/10.3892/ol.2011.477
  • Pages: 338-342
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Abstract

Hepatocellular carcinoma (HCC) is characterized by increased oxidative stress and the production of 8-hydroxy-2'-deoxyguanosine (8-OHdG), which is one of the main mutagenic modifications of DNA by oxidative stress. We analyzed the association of 8-OHdG with post-operative survival and revealed that low levels of 8-OHdG are associated with significantly shorter survival time. Moreover, levels of 8-OHdG were associated with HCC characteristics, including tumor size, tumor quantity, clinical staging, Child classification, portal vein thrombosis and ascites. These results suggest that oxidative damage is a useful prognostic marker in HCC when other clinical characteristics are present with 8-OHdG.
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February 2012
Volume 3 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Li S, Wang X, Wu Y, Zhang H, Zhang L, Wang C, Zhang R and Guo Z: 8-Hydroxy-2'-deoxyguanosine expression predicts hepatocellular carcinoma outcome. Oncol Lett 3: 338-342, 2012.
APA
Li, S., Wang, X., Wu, Y., Zhang, H., Zhang, L., Wang, C. ... Guo, Z. (2012). 8-Hydroxy-2'-deoxyguanosine expression predicts hepatocellular carcinoma outcome. Oncology Letters, 3, 338-342. https://doi.org/10.3892/ol.2011.477
MLA
Li, S., Wang, X., Wu, Y., Zhang, H., Zhang, L., Wang, C., Zhang, R., Guo, Z."8-Hydroxy-2'-deoxyguanosine expression predicts hepatocellular carcinoma outcome". Oncology Letters 3.2 (2012): 338-342.
Chicago
Li, S., Wang, X., Wu, Y., Zhang, H., Zhang, L., Wang, C., Zhang, R., Guo, Z."8-Hydroxy-2'-deoxyguanosine expression predicts hepatocellular carcinoma outcome". Oncology Letters 3, no. 2 (2012): 338-342. https://doi.org/10.3892/ol.2011.477