Association of CFTR gene polymorphisms with papillary thyroid cancer

Oh,In-Hwan; Oh,ChangMo; Yoon,Tai-Young; Choi,Joong-Myung; Kim,Su Kang; Park,Hae Jeong; Eun,Young Gyu; Chung,Dae Han; Kwon,Kee Hwan; Choe,Bong-Keun

doi:10.3892/ol.2011.479

February 2012 Volume 3 Issue 2

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February 2012 Volume 3 Issue 2

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Article

Association of CFTR gene polymorphisms with papillary thyroid cancer

Authors:
- In-Hwan Oh
- ChangMo Oh
- Tai-Young Yoon
- Joong-Myung Choi
- Su Kang Kim
- Hae Jeong Park
- Young Gyu Eun
- Dae Han Chung
- Kee Hwan Kwon
- Bong-Keun Choe
View Affiliations / Copyright

Affiliations: Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea, Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea, Department of Otolaryngology-Head and Neck Surgery, Changwon Samsung Hospital, Sungkyunkwan University, School of Medicine, Changwon 630-723, Republic of Korea, Department of Otolaryngology‑Head and Neck Surgery, School of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea
Pages: 455-461
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Published online on: November 15, 2011

https://doi.org/10.3892/ol.2011.479
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Abstract

The incidence of thyroid cancer has been on the increase in a number of countries, and certain genetic factors associated with the increased incidence of the papillary thyroid cancer (PTC) have been identified. However, little is known about the effect of mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, expressed in the thyroid. We hypothesized and investigated that CFTR single nucleotide polymorphisms (SNPs) may be associated with the risk and/or progression of PTC. A total of 105 PTC patients, confirmed by pathological tests, and 323 controls, without any thyroidal disease, were recruited. One promoter SNP (rs4148682) and one coding SNP (rs213950, Val470Met) in the CFTR gene were analyzed, using direct sequencing. The PTC patients were sub-grouped and compared by their clinical and pathological characteristics of PTC. The results showed that the association between SNPs in the CFTR gene and the development of PTC was statistically insignificant. However, in the clinical and pathological features, rs4148682 was found to be correlated with multifocal tumors, location and cervical node metastasis of PTC. rs231950 was also correlated with multifocal tumors, location and nodal metastasis of PTC. The G allele of rs213950 was correlated with increased risk of multifocal tumors and bilateral lobe location. However, in cervical lymph node metastasis, the A allele of rs213950 was found to reflect high risk. Our study suggests that the CFTR gene polymorphisms studied may not be associated with the development of PTC, but that rs4148682 and rs213950 may be associated with clinical features and prognosis, such as multifocality, location of cancer and cervical lymph node metastasis of PTC.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Association of CFTR gene polymorphisms with papillary thyroid cancer

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Abstract

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