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February 2012 Volume 3 Issue 2

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Article

Variation in myxoid liposarcoma: Clinicopathological examination of four cases with detectable TLS-CHOP or EWS-CHOP fusion transcripts whose histopathological diagnosis was other than myxoid liposarcoma

  • Authors:
    • Kayo Suzuki
    • Yoshito Matsui
    • Nobuyuki Hashimoto
    • Norifumi Naka
    • Nobuhito Araki
    • Tomoatsu Kimura
    • Hideki Yoshikawa
    • Takafumi Ueda
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedic Surgery, University of Toyama, Toyama 930-0194, Japan, Department of Orthopaedics, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan, Department of Orthopaedic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537-8511, Japan, Department of Orthopaedic Surgery, Osaka National Hospital, Osaka 540-0006, Japan
  • Pages: 293-296
    |
    Published online on: November 15, 2011
       https://doi.org/10.3892/ol.2011.480
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Abstract

Liposarcomas are separated into clinicopathological entities by a characteristic morphological spectrum and distinctive genetic changes. Myxoid liposarcoma (MLS) represents one such entity with specific chromosomal translocations leading to the generation of fusion genes, the human translocation liposarcoma (TLS)-CCAAT/enhancer binding protein (C/EBP) homologous protein (CHOP) or the Ewing sarcoma (EWS)-CHOP. In the present study, four cases of liposarcoma with detection of TLS-CHOP or EWS-CHOP, whose postoperative diagnosis was other than MLS (one well-differentiated liposarcoma, two de-differentiated liposarcomas and one unclassified) were examined for medical records, imaging data and histopathology. Clinical records demonstrated that three of the four cases were considerably difficult to diagnose definitively, and histopathological re-examination pointed out areas of myxomatous change as a minor component (<10%). Their dominant components (>90%) resembled pleomorphic sarcoma, pleomorphic malignant fibrous histiocytoma and monophasic synovial sarcoma. The current cases may represent an extreme variant of the morphological spectrum within MLS. In cases of difficulty in making definitive diagnosis of soft tissue sarcoma by standard histopathological examination and identification of myxoid stroma even as a minor component, analyzing TLS-CHOP and EWS-CHOP fusion genes may aid the diagnosis of unusual MLS.
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Copy and paste a formatted citation
Spandidos Publications style
Suzuki K, Matsui Y, Hashimoto N, Naka N, Araki N, Kimura T, Yoshikawa H and Ueda T: Variation in myxoid liposarcoma: Clinicopathological examination of four cases with detectable TLS-CHOP or EWS-CHOP fusion transcripts whose histopathological diagnosis was other than myxoid liposarcoma. Oncol Lett 3: 293-296, 2012.
APA
Suzuki, K., Matsui, Y., Hashimoto, N., Naka, N., Araki, N., Kimura, T. ... Ueda, T. (2012). Variation in myxoid liposarcoma: Clinicopathological examination of four cases with detectable TLS-CHOP or EWS-CHOP fusion transcripts whose histopathological diagnosis was other than myxoid liposarcoma. Oncology Letters, 3, 293-296. https://doi.org/10.3892/ol.2011.480
MLA
Suzuki, K., Matsui, Y., Hashimoto, N., Naka, N., Araki, N., Kimura, T., Yoshikawa, H., Ueda, T."Variation in myxoid liposarcoma: Clinicopathological examination of four cases with detectable TLS-CHOP or EWS-CHOP fusion transcripts whose histopathological diagnosis was other than myxoid liposarcoma". Oncology Letters 3.2 (2012): 293-296.
Chicago
Suzuki, K., Matsui, Y., Hashimoto, N., Naka, N., Araki, N., Kimura, T., Yoshikawa, H., Ueda, T."Variation in myxoid liposarcoma: Clinicopathological examination of four cases with detectable TLS-CHOP or EWS-CHOP fusion transcripts whose histopathological diagnosis was other than myxoid liposarcoma". Oncology Letters 3, no. 2 (2012): 293-296. https://doi.org/10.3892/ol.2011.480
Copy and paste a formatted citation
x
Spandidos Publications style
Suzuki K, Matsui Y, Hashimoto N, Naka N, Araki N, Kimura T, Yoshikawa H and Ueda T: Variation in myxoid liposarcoma: Clinicopathological examination of four cases with detectable TLS-CHOP or EWS-CHOP fusion transcripts whose histopathological diagnosis was other than myxoid liposarcoma. Oncol Lett 3: 293-296, 2012.
APA
Suzuki, K., Matsui, Y., Hashimoto, N., Naka, N., Araki, N., Kimura, T. ... Ueda, T. (2012). Variation in myxoid liposarcoma: Clinicopathological examination of four cases with detectable TLS-CHOP or EWS-CHOP fusion transcripts whose histopathological diagnosis was other than myxoid liposarcoma. Oncology Letters, 3, 293-296. https://doi.org/10.3892/ol.2011.480
MLA
Suzuki, K., Matsui, Y., Hashimoto, N., Naka, N., Araki, N., Kimura, T., Yoshikawa, H., Ueda, T."Variation in myxoid liposarcoma: Clinicopathological examination of four cases with detectable TLS-CHOP or EWS-CHOP fusion transcripts whose histopathological diagnosis was other than myxoid liposarcoma". Oncology Letters 3.2 (2012): 293-296.
Chicago
Suzuki, K., Matsui, Y., Hashimoto, N., Naka, N., Araki, N., Kimura, T., Yoshikawa, H., Ueda, T."Variation in myxoid liposarcoma: Clinicopathological examination of four cases with detectable TLS-CHOP or EWS-CHOP fusion transcripts whose histopathological diagnosis was other than myxoid liposarcoma". Oncology Letters 3, no. 2 (2012): 293-296. https://doi.org/10.3892/ol.2011.480
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