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Article

Mitotic arrest deficiency 2 induces carcinogenesis in mucinous ovarian tumors

  • Authors:
    • Yusuke Nakano
    • Toshiyuki Sumi
    • Masanari Morishita
    • Takeshi Fukuda
    • Hiroyuki Nobeyama
    • Hiroyuki Yoshida
    • Yoshinari Matsumoto
    • Tomoyo Yasui
    • Osamu Ishiko
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Asahimachi, Abeno-ku, Osaka 545-8585, Japan
  • Pages: 281-286
    |
    Published online on: November 15, 2011
       https://doi.org/10.3892/ol.2011.483
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Abstract

Mitotic arrest deficiency 2 (MAD2) is a key component of the mitotic spindle checkpoint pathway. A compromised mitotic spindle checkpoint results in an abnormal number of chromosomes. This is referred to as chromosomal instability, and has been reported in most types of human cancer. The aim of this study was to examine the expression of MAD2 in mucinous ovarian tumors exhibiting varying degrees of malignancy. We reviewed 128 cases of mucinous ovarian tumors initially treated at Osaka City University Medical School Hospital, Japan. Tumor samples were obtained following surgery. The cases were divided into three groups: benign (group B; n=30), borderline malignant (group BM; n=55) and malignant (group M; n=43). MAD2 expression was examined in paraffin‑embedded sections using the avidin-biotin peroxidase complex method. Results showed MAD2 expression to be significantly greater in group M compared to groups B and BM (P<0.05). In addition, there was a moderate correlation between MAD2 expression and the degree of malignancy (r=0.51, P<0.05). However, when the samples in group M were classified according to a low or high expression of MAD2, no difference was observed in terms of overall survival. These findings suggest that the overexpression of MAD2 may be correlated to carcinogenesis in mucinous ovarian tumors.
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Copy and paste a formatted citation
Spandidos Publications style
Nakano Y, Sumi T, Morishita M, Fukuda T, Nobeyama H, Yoshida H, Matsumoto Y, Yasui T and Ishiko O: Mitotic arrest deficiency 2 induces carcinogenesis in mucinous ovarian tumors. Oncol Lett 3: 281-286, 2012.
APA
Nakano, Y., Sumi, T., Morishita, M., Fukuda, T., Nobeyama, H., Yoshida, H. ... Ishiko, O. (2012). Mitotic arrest deficiency 2 induces carcinogenesis in mucinous ovarian tumors. Oncology Letters, 3, 281-286. https://doi.org/10.3892/ol.2011.483
MLA
Nakano, Y., Sumi, T., Morishita, M., Fukuda, T., Nobeyama, H., Yoshida, H., Matsumoto, Y., Yasui, T., Ishiko, O."Mitotic arrest deficiency 2 induces carcinogenesis in mucinous ovarian tumors". Oncology Letters 3.2 (2012): 281-286.
Chicago
Nakano, Y., Sumi, T., Morishita, M., Fukuda, T., Nobeyama, H., Yoshida, H., Matsumoto, Y., Yasui, T., Ishiko, O."Mitotic arrest deficiency 2 induces carcinogenesis in mucinous ovarian tumors". Oncology Letters 3, no. 2 (2012): 281-286. https://doi.org/10.3892/ol.2011.483
Copy and paste a formatted citation
x
Spandidos Publications style
Nakano Y, Sumi T, Morishita M, Fukuda T, Nobeyama H, Yoshida H, Matsumoto Y, Yasui T and Ishiko O: Mitotic arrest deficiency 2 induces carcinogenesis in mucinous ovarian tumors. Oncol Lett 3: 281-286, 2012.
APA
Nakano, Y., Sumi, T., Morishita, M., Fukuda, T., Nobeyama, H., Yoshida, H. ... Ishiko, O. (2012). Mitotic arrest deficiency 2 induces carcinogenesis in mucinous ovarian tumors. Oncology Letters, 3, 281-286. https://doi.org/10.3892/ol.2011.483
MLA
Nakano, Y., Sumi, T., Morishita, M., Fukuda, T., Nobeyama, H., Yoshida, H., Matsumoto, Y., Yasui, T., Ishiko, O."Mitotic arrest deficiency 2 induces carcinogenesis in mucinous ovarian tumors". Oncology Letters 3.2 (2012): 281-286.
Chicago
Nakano, Y., Sumi, T., Morishita, M., Fukuda, T., Nobeyama, H., Yoshida, H., Matsumoto, Y., Yasui, T., Ishiko, O."Mitotic arrest deficiency 2 induces carcinogenesis in mucinous ovarian tumors". Oncology Letters 3, no. 2 (2012): 281-286. https://doi.org/10.3892/ol.2011.483
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