Safety creatinine clearance level for platinum chemotherapy in lung cancer patients

Ohara,Gen; Miyazaki,Kunihiko; Kurishima,Koichi; Kagohashi,Katsunori; Ishikawa,Hiroichi; Satoh,Hiroaki; Hizawa,Nobuyuki

doi:10.3892/ol.2011.486

February 2012 Volume 3 Issue 2

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February 2012 Volume 3 Issue 2

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Article

Safety creatinine clearance level for platinum chemotherapy in lung cancer patients

Authors:
- Gen Ohara
- Kunihiko Miyazaki
- Koichi Kurishima
- Katsunori Kagohashi
- Hiroichi Ishikawa
- Hiroaki Satoh
- Nobuyuki Hizawa
View Affiliations / Copyright

Affiliations: Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Ibaraki 310-0015, Japan, Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan, Division of Respiratory Medicine, Tsukuba Medical Center, Tsubuka, Ibaraki, Japan
Pages: 311-314
|
Published online on: November 16, 2011

https://doi.org/10.3892/ol.2011.486
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Abstract

The present study was carried out to evaluate whether measured‑creatinine clearance (measured‑CrCl) and Cockcroft and Gault-CrCl (CG‑CrCl) are capable of appropriately detecting a decline in renal function in lung cancer patients, including elderly patients, and to clarify a CrCl level with which to discriminate between patients with or without renal impairment. The measured‑CrCl prior and subsequent to platinum‑based chemotherapy of lung cancer patients was retrospectively analyzed. Measured‑CrCl and CG‑CrCl were evaluated prior and subsequent to platinum‑based chemotherapy for lung cancer. Measured-CrCl and CG‑CrCl in 59 lung cancer patients including 25 patients aged ≥65 years were retrospectively analyzed. In patients treated with carboplatin‑based chemotherapy, measured‑CrCl was indicative of a decline in renal function, whereas CG‑CrCl was not. The optimal measured-CrCl level was <60 ml/min post-pretreatment and >90 ml/min at pre-treatment. In cases with pre‑treatment measured-CrCl levels of >90 ml/min, favorable renal function is necessary in order to carry out platinum-based chemotherapy in lung cancer patients, including the elderly.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Safety creatinine clearance level for platinum chemotherapy in lung cancer patients

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