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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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February 2012 Volume 3 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Terpinolene, a component of herbal sage, downregulates AKT1 expression in K562 cells

  • Authors:
    • Naoko Okumura
    • Hitomi Yoshida
    • Yuri Nishimura
    • Yasuko Kitagishi
    • Satoru Matsuda

  • View Affiliations / Copyright

    Affiliations: Department of Environmental Health Science, Nara Women's University, Nara 630-8506, Japan
  • Pages: 321-324
    |
    Published online on: November 18, 2011
       https://doi.org/10.3892/ol.2011.491
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Abstract

Protein kinase AKT mediates cell proliferation and survival signals, and also contributes to cancer progression. Increased expression and/or activation of AKT is involved in a variety of human cancers. In cells treated with sage or rosemary extract, mRNA and protein expression levels of AKT1 were reduced compared with those of the control cells 48 h after the herbal treatments. We found that terpinolene, a common component of sage and rosemary, markedly reduced the protein expression of AKT1 in K562 cells and inhibited cell proliferation.
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Copy and paste a formatted citation
Spandidos Publications style
Okumura N, Yoshida H, Nishimura Y, Kitagishi Y and Matsuda S: Terpinolene, a component of herbal sage, downregulates AKT1 expression in K562 cells. Oncol Lett 3: 321-324, 2012.
APA
Okumura, N., Yoshida, H., Nishimura, Y., Kitagishi, Y., & Matsuda, S. (2012). Terpinolene, a component of herbal sage, downregulates AKT1 expression in K562 cells. Oncology Letters, 3, 321-324. https://doi.org/10.3892/ol.2011.491
MLA
Okumura, N., Yoshida, H., Nishimura, Y., Kitagishi, Y., Matsuda, S."Terpinolene, a component of herbal sage, downregulates AKT1 expression in K562 cells". Oncology Letters 3.2 (2012): 321-324.
Chicago
Okumura, N., Yoshida, H., Nishimura, Y., Kitagishi, Y., Matsuda, S."Terpinolene, a component of herbal sage, downregulates AKT1 expression in K562 cells". Oncology Letters 3, no. 2 (2012): 321-324. https://doi.org/10.3892/ol.2011.491
Copy and paste a formatted citation
x
Spandidos Publications style
Okumura N, Yoshida H, Nishimura Y, Kitagishi Y and Matsuda S: Terpinolene, a component of herbal sage, downregulates AKT1 expression in K562 cells. Oncol Lett 3: 321-324, 2012.
APA
Okumura, N., Yoshida, H., Nishimura, Y., Kitagishi, Y., & Matsuda, S. (2012). Terpinolene, a component of herbal sage, downregulates AKT1 expression in K562 cells. Oncology Letters, 3, 321-324. https://doi.org/10.3892/ol.2011.491
MLA
Okumura, N., Yoshida, H., Nishimura, Y., Kitagishi, Y., Matsuda, S."Terpinolene, a component of herbal sage, downregulates AKT1 expression in K562 cells". Oncology Letters 3.2 (2012): 321-324.
Chicago
Okumura, N., Yoshida, H., Nishimura, Y., Kitagishi, Y., Matsuda, S."Terpinolene, a component of herbal sage, downregulates AKT1 expression in K562 cells". Oncology Letters 3, no. 2 (2012): 321-324. https://doi.org/10.3892/ol.2011.491
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