A case of early stage lung cancer detected by repeated cancer screening with positron emission tomography

Sakata,Ikuko; Ozeki,Yuichi; Tamura,Katsumi; Ishida,Jiro; Aida,Shinsuke; Abe,Yoshiyuki

doi:10.3892/ol.2011.492

A case of early stage lung cancer detected by repeated cancer screening with positron emission tomography

Authors:
- Ikuko Sakata
- Yuichi Ozeki
- Katsumi Tamura
- Jiro Ishida
- Shinsuke Aida
- Yoshiyuki Abe
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Affiliations: Tokorozawa PET Diagnostic Imaging Clinic, Tokorozawa, Saitama 359-1124, Japan, Department of Thoracic Surgery, National Defense Medical College, Tokorozawa, Saitama 359-1124, Japan, Department of Diagnostic Pathology, National Defense Medical College, Tokorozawa, Saitama 359-1124, Japan
Published online on: November 22, 2011 https://doi.org/10.3892/ol.2011.492
Pages: 297-299

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Abstract

There has been an increase in the detection rate of small early lung cancer due to recent improvements in imaging technology. However, conventional imaging modalities such as computed tomography (CT) alone are not capable of differentiating small pulmonary nodules. New modalities such as F-18 2'-deoxy-2fluoro-D-glucose (FDG) positron emission tomography combined with CT (PET/CT) have contributed to the evaluation of lung cancer staging, although the differential diagnosis of pulmonary nodules showing ground-glass opacity (GGO) with PET/CT is controversial. In Japan, cancer screening with whole body FDG-PET has been available for asymptomatic individuals, and it has been reported that a wide variety of cancer types are detectable by FDG-PET at potentially curable stages. We present the case of a 62-year-old male with early lung cancer, which was revealed by repeated health screening. A PET/CT scan revealed definite intense FDG uptake (SUVmax 1.2) in the pulmonary nodules of the right upper lobe, while no definite FDG uptake was observed in the lesion in the previous annual screening. Right upper lobectomy was performed, and the pathological diagnosis was well-differentiated adenocarcinoma. Five-year survival has been noted since the thoracotomy, and the patient is doing well without recurrence. This is a significant case of early lung cancer with GGO lesions, which revealed intense FDG uptake during an annual repeated health screening with FDG-PET/CT.

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1	Kaneko M, Eguchi K, Ohmatsu H, Kakinuma R, Naruke T, Suemasu K and Moriyama N: Peripheral lung cancer: screening and detection with low-dose spiral CT versus radiography. Radiology. 201:798–802. 1996. View Article : Google Scholar : PubMed/NCBI
2	Abe Y, Hanai K, Nakano M, Ohkubo Y, Hashizume T, Kakizaki T, Nakamura M, Niki N, Egichi K, Fujino T and Moriyama N: A computer-aided diagnosis (CAD) system in lung cancer screening with computed tomography. Anticancer Res. 25:483–488. 2005.PubMed/NCBI
3	Abe Y, Nakamura M, Ozeki Y, Machida K and Ogata T: Lung cancer: Low-dose helical computed tomography. Cancer Imaging: Lung and Breast Carcinoma. 1. Hayat MA: Elsevier; Academic Press; pp. 203–207. 2007
4	Nakata M, Saeki H, Takata I, Segawa Y, Mogami H, Mandai K and Eguchi K: Focal ground-glass opacity detected by low-dose helical CT. Chest. 121:1464–1467. 2002. View Article : Google Scholar : PubMed/NCBI
5	Gould MK, Maclean CC, Kuschner WG, Rydzak CE and Owens DK: Accuracy of positron emission tomography for diagnosis of pulmonary nodules and mass lesions: a meta-analysis. JAMA. 285:914–924. 2001. View Article : Google Scholar : PubMed/NCBI
6	Kim SK, Allen-Auerbach M, Goldin J, Fueger BJ, Dahlbom M, Brown M, Czernin J and Schiepers C: Accuracy of PET/CT in characterization of solitary pulmonary lesions. J Nucl Med. 48:214–220. 2007.PubMed/NCBI
7	Yasuda S and Shohtsu A: Cancer screening with whole-body 18F-fluorodeoxyglucose positron-emission tomography. Lancet. 350:18191997. View Article : Google Scholar : PubMed/NCBI
8	Yasuda S, Ide M, Fujii H, Nakahara T, Mochizuki Y, Takahashi W and Shohtsu A: Application of positron emission tomography imaging to cancer screening. Br J Cancer. 83:1607–1611. 2000. View Article : Google Scholar : PubMed/NCBI
9	Ide M: Cancer screening with FDG-PET. Q J Nucl Med Mol Imaging. 50:23–27. 2006.PubMed/NCBI
10	Cronin CG, Swords R, Truong MT, Viswanathan C, Rohren E, Giles FJ, O’Dwyer M and Bruzzi JF: Clinical utility of PET/CT in lymphoma. AJR Am J Roentgenol. 194:W91–W103. 2010. View Article : Google Scholar : PubMed/NCBI
11	Ueda S, Saeki T, Tsuda H, Shigekawa T, Omata J, Moriya T, Yamamoto J, Osaki A, Fujiuchi N, Misumi M, et al: 18F-fluorodeoxyglucose positron emission tomography optimizes neoadjuvant chemotherapy for primary breast cancer to achieve pathological complete response. Int J Clin Oncol. 2011.(E-pub ahead of print).
12	Xie L, Saynak M, Veeramachaneni NK, Fried DV, Jagtap MR, Chiu WK, Higginson DS, Lawrence MV, Khandani AH, Qaqish BF, Chen RC and Marks LB: Non-small cell lung cancer: Prognostic importance of positive FDG PET findings in the mediastinum for patients with N0-1 disease at pathologic analysis. Radiology. 2011.(E-pub ahead of print).
13	Abe Y, Tamura K, Sakata I, Ishida J, Ozeki Y, Tamura A, Uematsu K, Sakai H, Goya T, Kanazawa M and Machida K: Clinical implications of ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) at delayed phase for diagnosis and prognosis of malignant pleural mesothelioma. Oncol Rep. 2011 Oct 24; View Article : Google Scholar : (Epub ahead of print).
14	Chun EJ, Lee HJ, Kang WJ, Kim KG, Goo JM, Park CM and Lee CH: Differentiation between malignancy and inflammation in pulmonary ground-glass nodules: the feasibility of integrated (18)F-FDG PET/CT. Lung Cancer. 65:180–186. 2009. View Article : Google Scholar : PubMed/NCBI
15	Fischer B, Lassen U, Mortensen J, Larsen S, Loft A, Bertelsen A, Ravn J, Clementsen P, Høgholm A, Larsen K, et al: Preoperative staging of lung cancer with combined PET-CT. N Engl J Med. 361:32–39. 2009. View Article : Google Scholar : PubMed/NCBI
16	Cloran FJ, Banks KP, Song WS, Kim and Bradley YC: Limitations of dual time point PET in the assessment of lung nodules with low FDG avidity. Lung Cancer. 68:66–71. 2010. View Article : Google Scholar : PubMed/NCBI
17	Fischer BM, Lassen U and Højgaard L: PET-CT in preoperative staging of lung cancer. N Engl J Med. 364:980–981. 2011. View Article : Google Scholar : PubMed/NCBI
18	Abe Y, Tamura K, Sakata I, Ishida J, Fukuba I, Matsuoka R, Shimizu S, Murakami H and Machida K: Usefulness of ¹⁸F-FDG positron emission tomography/computed tomography for the diagnosis of pyothorax-associated lymphoma: A report of three cases. Oncol Lett. 1:833–836. 2010.
19	Henschke CI, Boffetta P, Gorlova O, Yip R, Delancey JO and Foy M: Assessment of lung-cancer mortality reduction from CT screening. Lung Cancer. 71:328–332. 2011. View Article : Google Scholar : PubMed/NCBI
20	Fleming AJ Jr and Johansen ME: The clinician’s expectations from the use of positron emission tomography/computed tomography scanning in untreated and treated head and neck cancer patients. Curr Opin Otolaryngol Head Neck Surg. 16:127–134. 2008.
21	Ueda S, Tsuda H, Asakawa H, Shigekawa T, Fukatsu K, Kondo N, Yamamoto M, Hama Y, Tamura K, Ishida J, Abe Y and Mochizuki H: Clinicopathological and prognostic relevance of uptake level using 18F-fluorodeoxyglucose positron emission tomography computed tomography fusion imaging (18F-FDG PET/CT) in primary breast cancer. Jpn J Clin Oncol. 38:250–258. 2008. View Article : Google Scholar
22	Abe Y, Tamura K, Sakata I, Ishida J, Mukai M, Ohtaki M, Nakamura M and Machida K: Unique intense uptake demonstrated by ¹⁸F-FDG positron emission tomography/computed tomography (PET/CT) in primary pancreatic lymphoma: A case report. Oncol Lett. 1:605–607. 2010.PubMed/NCBI
23	Ozeki Y, Abe Y, Kita H, Tamura K, Sakata I, Ishida J and Machida K: A case of primary lung cancer lesion demonstrated by F-18 FDG positron emission tomography/computed tomography (PET/CT) one year after the detection of metastatic brain tumor. Oncol Lett. 2:621–623. 2011.PubMed/NCBI
24	Abe Y, Tamura T, Sakata I, Ishida J, Nagata M, Machida K and Ogata T: Lung cancer: Computer-aided diagnosis with computed tomography. Cancer Imaging: Lung and Breast Carcinoma. 1. Hayat MA: Elsevier; Academic Press; pp. 209–214. 2007
25	Suzuki K, Kusumoto M, Watanabe S, Tsuchiya R and Asamura H: Radiologic classification of small adenocarcinoma of the lung: radiologic-pathologic correlation and its prognostic impact. Ann Thorac Surg. 81:413–419. 2006. View Article : Google Scholar : PubMed/NCBI
26	Murano T, Minamimoto R, Senda M, Uno K, Jinnouchi S, Fukuda H, Iinuma T, Tsukamoto E, Terauchi T, Yoshida T, et al: Radiation exposure and risk-benefit analysis in cancer screening using FDG-PET: results of a Japanese nationwide survey. Ann Nucl Med. 2011.(E-pub ahead of print).