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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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February 2012 Volume 3 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Good response to leucovorin and fluorouracil plus oxaliplatin and cetuximab therapy in a patient with metastatic ascending colon cancer harboring a KRAS p.G13D mutation

  • Authors:
    • Takumi Ochiai
    • Kazuhiko Nishimura
    • Tomoo Watanabe
    • Masayuki Kitajima
    • Akinori Nakatani
    • Takashi Inou
    • Marie Washio
    • Naoki Sakuyama
    • Tsuyoshi Sato
    • Kenji Kishine
    • Takanori Ochi
    • Satoshi Ookubo
    • Shunji Futagawa
    • Hideki Orikasa
    • Satomi Mashiko
    • Isao Nagaoka
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Tobu Chiiki Hospital, Tokyo Metropolitan Health and Medical Treatment Corporation, Tokyo 125-8512, Japan, Department of Pathology, Tobu Chiiki Hospital, Tokyo Metropolitan Health and Medical Treatment Corporation, Tokyo 125-8512, Japan, Department of Pharmacy, Tobu Chiiki Hospital, Tokyo Metropolitan Health and Medical Treatment Corporation, Tokyo 125-8512, Japan, Department of Host Defense and Biochemical Research, Juntendo University School of Medicine, Tokyo 113-8421, Japan
  • Pages: 269-272
    |
    Published online on: November 30, 2011
       https://doi.org/10.3892/ol.2011.503
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Abstract

The effectiveness of cetuximab (Cmab) against KRAS p.G13D mutant-type tumors has been reported. In this study, we report a case of metastatic ascending colon cancer harboring a KRAS p.G13D mutation in a 65-year‑old female. Considering the absence of symptoms and the post‑operative risk of respiratory system complications due to multiple lung metastases, particularly at the entrance to the left main bronchus, anticancer drug therapy was selected as first-line therapy. With informed consent, FOLFOX4 [folinic acid (FOL), fluorouracil (F) plus oxaliplatin (OX)] + Cmab therapy was administered as preoperative chemotherapy. A good preoperative response was obtained to the chemotherapy, with a metastatic lesion disappearing from the entrance to the left main bronchus. Subsequent resection was performed successfully with no post‑operative complications. Although a histopathological examination of the resected tissue specimen revealed residual cancer cells, it also showed the marked efficacy of the chemotherapy regimen used. In this study, we describe a case of metastatic ascending colon cancer harboring a KRAS p.G13D mutation in which the patient responded well to first‑line therapy with FOLFOX4 + Cmab.
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Copy and paste a formatted citation
Spandidos Publications style
Ochiai T, Nishimura K, Watanabe T, Kitajima M, Nakatani A, Inou T, Washio M, Sakuyama N, Sato T, Kishine K, Kishine K, et al: Good response to leucovorin and fluorouracil plus oxaliplatin and cetuximab therapy in a patient with metastatic ascending colon cancer harboring a KRAS p.G13D mutation. Oncol Lett 3: 269-272, 2012.
APA
Ochiai, T., Nishimura, K., Watanabe, T., Kitajima, M., Nakatani, A., Inou, T. ... Nagaoka, I. (2012). Good response to leucovorin and fluorouracil plus oxaliplatin and cetuximab therapy in a patient with metastatic ascending colon cancer harboring a KRAS p.G13D mutation. Oncology Letters, 3, 269-272. https://doi.org/10.3892/ol.2011.503
MLA
Ochiai, T., Nishimura, K., Watanabe, T., Kitajima, M., Nakatani, A., Inou, T., Washio, M., Sakuyama, N., Sato, T., Kishine, K., Ochi, T., Ookubo, S., Futagawa, S., Orikasa, H., Mashiko, S., Nagaoka, I."Good response to leucovorin and fluorouracil plus oxaliplatin and cetuximab therapy in a patient with metastatic ascending colon cancer harboring a KRAS p.G13D mutation". Oncology Letters 3.2 (2012): 269-272.
Chicago
Ochiai, T., Nishimura, K., Watanabe, T., Kitajima, M., Nakatani, A., Inou, T., Washio, M., Sakuyama, N., Sato, T., Kishine, K., Ochi, T., Ookubo, S., Futagawa, S., Orikasa, H., Mashiko, S., Nagaoka, I."Good response to leucovorin and fluorouracil plus oxaliplatin and cetuximab therapy in a patient with metastatic ascending colon cancer harboring a KRAS p.G13D mutation". Oncology Letters 3, no. 2 (2012): 269-272. https://doi.org/10.3892/ol.2011.503
Copy and paste a formatted citation
x
Spandidos Publications style
Ochiai T, Nishimura K, Watanabe T, Kitajima M, Nakatani A, Inou T, Washio M, Sakuyama N, Sato T, Kishine K, Kishine K, et al: Good response to leucovorin and fluorouracil plus oxaliplatin and cetuximab therapy in a patient with metastatic ascending colon cancer harboring a KRAS p.G13D mutation. Oncol Lett 3: 269-272, 2012.
APA
Ochiai, T., Nishimura, K., Watanabe, T., Kitajima, M., Nakatani, A., Inou, T. ... Nagaoka, I. (2012). Good response to leucovorin and fluorouracil plus oxaliplatin and cetuximab therapy in a patient with metastatic ascending colon cancer harboring a KRAS p.G13D mutation. Oncology Letters, 3, 269-272. https://doi.org/10.3892/ol.2011.503
MLA
Ochiai, T., Nishimura, K., Watanabe, T., Kitajima, M., Nakatani, A., Inou, T., Washio, M., Sakuyama, N., Sato, T., Kishine, K., Ochi, T., Ookubo, S., Futagawa, S., Orikasa, H., Mashiko, S., Nagaoka, I."Good response to leucovorin and fluorouracil plus oxaliplatin and cetuximab therapy in a patient with metastatic ascending colon cancer harboring a KRAS p.G13D mutation". Oncology Letters 3.2 (2012): 269-272.
Chicago
Ochiai, T., Nishimura, K., Watanabe, T., Kitajima, M., Nakatani, A., Inou, T., Washio, M., Sakuyama, N., Sato, T., Kishine, K., Ochi, T., Ookubo, S., Futagawa, S., Orikasa, H., Mashiko, S., Nagaoka, I."Good response to leucovorin and fluorouracil plus oxaliplatin and cetuximab therapy in a patient with metastatic ascending colon cancer harboring a KRAS p.G13D mutation". Oncology Letters 3, no. 2 (2012): 269-272. https://doi.org/10.3892/ol.2011.503
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