S-1 monotherapy for previously treated non-small cell lung cancer: A retrospective analysis by age and histopathological type

Tomita,Yuki; Oguri,Tetsuya; Takakuwa,Osamu; Nakao,Makoto; Kunii,Eiji; Uemura,Takehiro; Ozasa,Hiroaki; Miyazaki,Mikinori; Maeno,Ken; Sato,Shigeki

doi:10.3892/ol.2011.507

February 2012 Volume 3 Issue 2

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February 2012 Volume 3 Issue 2

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Article

S-1 monotherapy for previously treated non-small cell lung cancer: A retrospective analysis by age and histopathological type

Authors:
- Yuki Tomita
- Tetsuya Oguri
- Osamu Takakuwa
- Makoto Nakao
- Eiji Kunii
- Takehiro Uemura
- Hiroaki Ozasa
- Mikinori Miyazaki
- Ken Maeno
- Shigeki Sato
View Affiliations / Copyright

Affiliations: Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan
Pages: 405-410
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Published online on: December 1, 2011

https://doi.org/10.3892/ol.2011.507
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Abstract

S-1, an oral fluoropyrimidine derivative, has been approved for the treatment of non-small cell lung cancer (NSCLC) in Japan. In the present study, the efficacy and safety of S-1 monotherapy for elderly patients with previously treated NSCLC were retrospectively evaluated, and the efficacy of S-1 monotherapy was compared by histopathological type. This retrospective study included 54 patients with advanced or recurrent NSCLC who had received S-1 monotherapy following the failure of previous chemotherapy regimens at our institutes. Patient outcomes were compared based on their age and histopathological type. S-1 was administered orally, twice daily, while the duration and interval were modified according to the medical condition of each patient. The default delivery schedule, the mean number of S-1 cycles, did not differ significantly between the two age groups (<70 and ≥70 years). The rate of therapy discontinuation, schedule modification or dose reduction due to intolerable toxicities or patient refusal was relatively frequent in the older group (40.7 and 55.6% for ages <70 and ≥70 years, respectively; p=0.414), and the incidence of grade 3 anemia was relatively high in the older group (3.7 and 18.5%, respectively; p=0.192). The response rates (13.0 and 4.8%, respectively; p=0.609) and disease control rates (39.1 and 33.3%, respectively; p=0.761) did not differ significantly between the two age groups. According to histopathological type, the disease control rate was significantly higher in adenocarcinoma (57.9%) compared to non-adenocarcinoma (20.0%, p=0.013). Thus, S-1 monotherapy may be equally effective and tolerated in patients <70 years and those ≥70 years. Additionally, adenocarcinoma may have a higher disease control rate than non-adenocarcinoma.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

S-1 monotherapy for previously treated non-small cell lung cancer: A retrospective analysis by age and histopathological type

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