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February 2012 Volume 3 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article

Optimal use of current chemotherapy in multimodality therapy for advanced colorectal cancer

  • Authors:
    • Yasuhiro Inoue
    • Junichiro Hiro
    • Yuji Toiyama
    • Koji Tanaka
    • Yasuhiko Mohri
    • Masato Kusunoki
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Mie, Japan
  • Pages: 363-368
    |
    Published online on: December 1, 2011
       https://doi.org/10.3892/ol.2011.508
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Abstract

Treatment of advanced colorectal cancer (CRC) increasingly requires a multimodality approach, which adds to the complexity of clinical decision-making. This study investigates the optimal use of current chemotherapy in multimodality therapy for advanced CRC. We enrolled 208 patients with unresectable primary and metastatic (recurrent) CRC who underwent chemotherapy in our hospital. Radiofrequency ablation and/or secondary surgery were used depending on tumor response to chemotherapy. Disease sites varied among patients and included unresectable liver, lung and peritoneal metastasis. Chemotherapy produced cytoreduction in 71 of 208 patients (34%). Multimodality cytoreduction increased overall survival to a median of 46.0 months vs. 20.2 months with chemotherapy alone (P<0.0001). The response rate to chemotherapy was independently associated with cytoreduction. Molecular targeted therapy reduced the number of tumor cells sooner than conventional chemotherapy, and correlated with repeated cytoreduction that further prolonged survival. Aggressive chemotherapy as initial treatment for advanced CRC leads to cytoreduction and is associated with extended survival in patients receiving multimodality therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Inoue Y, Hiro J, Toiyama Y, Tanaka K, Mohri Y and Kusunoki M: Optimal use of current chemotherapy in multimodality therapy for advanced colorectal cancer. Oncol Lett 3: 363-368, 2012.
APA
Inoue, Y., Hiro, J., Toiyama, Y., Tanaka, K., Mohri, Y., & Kusunoki, M. (2012). Optimal use of current chemotherapy in multimodality therapy for advanced colorectal cancer. Oncology Letters, 3, 363-368. https://doi.org/10.3892/ol.2011.508
MLA
Inoue, Y., Hiro, J., Toiyama, Y., Tanaka, K., Mohri, Y., Kusunoki, M."Optimal use of current chemotherapy in multimodality therapy for advanced colorectal cancer". Oncology Letters 3.2 (2012): 363-368.
Chicago
Inoue, Y., Hiro, J., Toiyama, Y., Tanaka, K., Mohri, Y., Kusunoki, M."Optimal use of current chemotherapy in multimodality therapy for advanced colorectal cancer". Oncology Letters 3, no. 2 (2012): 363-368. https://doi.org/10.3892/ol.2011.508
Copy and paste a formatted citation
x
Spandidos Publications style
Inoue Y, Hiro J, Toiyama Y, Tanaka K, Mohri Y and Kusunoki M: Optimal use of current chemotherapy in multimodality therapy for advanced colorectal cancer. Oncol Lett 3: 363-368, 2012.
APA
Inoue, Y., Hiro, J., Toiyama, Y., Tanaka, K., Mohri, Y., & Kusunoki, M. (2012). Optimal use of current chemotherapy in multimodality therapy for advanced colorectal cancer. Oncology Letters, 3, 363-368. https://doi.org/10.3892/ol.2011.508
MLA
Inoue, Y., Hiro, J., Toiyama, Y., Tanaka, K., Mohri, Y., Kusunoki, M."Optimal use of current chemotherapy in multimodality therapy for advanced colorectal cancer". Oncology Letters 3.2 (2012): 363-368.
Chicago
Inoue, Y., Hiro, J., Toiyama, Y., Tanaka, K., Mohri, Y., Kusunoki, M."Optimal use of current chemotherapy in multimodality therapy for advanced colorectal cancer". Oncology Letters 3, no. 2 (2012): 363-368. https://doi.org/10.3892/ol.2011.508
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