The role of human papillomavirus type 16 E6/E7 oncoproteins in cervical epithelial-mesenchymal transition and carcinogenesis

  • Authors:
    • Ya-Min Cheng
    • Cheng-Yang Chou
    • Yi-Chiang Hsu
    • Ming-Jenn Chen
    • Lih-Yuh C. Wing
  • View Affiliations

  • Published online on: December 5, 2011     https://doi.org/10.3892/ol.2011.512
  • Pages: 667-671
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Cervical cancer is the most common malignancy in females worldwide. This study investigated the prevalence of the E6/E7 oncoproteins of human papillomavirus (HPV) type 16, which are important in fibroblast growth factor (FGF) 2- and 4-induced epithelial-mesenchymal transition (EMT) and cervical tumorigenesis. We investigated the functional interaction between HPV16 E6/E7-transfected Cx cells (CxWJ cells) and treatment with FGF2 and 4, according to the expression of α-smooth muscle actin (α-SMA), vimentin and E-cadherin protein as well as cell growth and invasive ability. The results showed the upregulation of α-SMA and vimentin and the downregulation of E-cadherin protein expression in CxWJ cells. HPV16 E6/E7 infection partially repressed proliferation, but not the invasive ability of FGF2 or FGF4 stimulation in cervical cancer cells (CxWJ cells). These data provide evidence of a functional interaction between HPV16 E6/E7 and FGFs 2 and 4, suggesting that cooperative stimulation of HPV E6/E7 and FGFs activated in human cervical cancer cells is required to completely overcome the oncogenic function associated with the development of cervical epithelial-mesenchymal transition and tumorigenesis.
View Figures
View References

Related Articles

Journal Cover

March 2012
Volume 3 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Cheng Y, Chou C, Hsu Y, Chen M and Wing LC: The role of human papillomavirus type 16 E6/E7 oncoproteins in cervical epithelial-mesenchymal transition and carcinogenesis. Oncol Lett 3: 667-671, 2012
APA
Cheng, Y., Chou, C., Hsu, Y., Chen, M., & Wing, L.C. (2012). The role of human papillomavirus type 16 E6/E7 oncoproteins in cervical epithelial-mesenchymal transition and carcinogenesis. Oncology Letters, 3, 667-671. https://doi.org/10.3892/ol.2011.512
MLA
Cheng, Y., Chou, C., Hsu, Y., Chen, M., Wing, L. C."The role of human papillomavirus type 16 E6/E7 oncoproteins in cervical epithelial-mesenchymal transition and carcinogenesis". Oncology Letters 3.3 (2012): 667-671.
Chicago
Cheng, Y., Chou, C., Hsu, Y., Chen, M., Wing, L. C."The role of human papillomavirus type 16 E6/E7 oncoproteins in cervical epithelial-mesenchymal transition and carcinogenesis". Oncology Letters 3, no. 3 (2012): 667-671. https://doi.org/10.3892/ol.2011.512