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Article

Polymorphisms of mismatch repair gene hMLH1 and hMSH2 and risk of gastric cancer in a Chinese population

  • Authors:
    • Xian-Qiu Xiao
    • Wei-Da Gong
    • Shi-Zhi Wang
    • Zheng-Dong Zhang
    • Xiao-Ping Rui
    • Guo-Zhong Wu
    • Feng Ren
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, the 101th Chinese People's Liberation Army Hospital, Jiangsu, P.R. China, Department of General Surgery, Cancer Hospital of Yixing, Jiangsu, P.R. China, Department of Molecular and Genetic Toxicology, Cancer Center of Nanjing Medical University, Jiangsu, P.R. China, Department of Clinical Laboratory, the Fourth Affiliated Hospital of Soochow University, Jiangsu 214062, P.R. China
  • Pages: 591-598
    |
    Published online on: December 6, 2011
       https://doi.org/10.3892/ol.2011.517
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Abstract

The purpose of this study was to determine the genotype and allele frequencies of hMLH1 (-93G>A and I219V) and hMSH2 (-118T>C and IVS12-6T>C) polymorphisms in patients with gastric carcinoma and normal controls, and to evaluate the association between these polymorphisms and the risk of gastric cancer in a hospital-based Chinese population. Genomic DNA was extracted from peripheral blood lymphocytes. A TaqMan assay was used to determine the genotype and allele frequencies of hMLH1 and hMSH2 polymorphisms in data obtained from 554 gastric cancer cases and 592 controls. Unconditional logistic regression was used to assess the association between the four single nucleotide polymorphisms (SNPs) and gastric carcinoma risk. No evidence of an association among any of the four polymorphisms and the risk of gastric cancer was observed. However, when gastric cancer patients were further stratified by age, gender, smoking status, alcohol use and clinicopathological characteristics, and compared with the control populations, the combined variant genotype hMSH2 -118T>C (TC+CC) was not only associated with an increased risk of gastric cancer in subgroups of younger subjects [ages ≤63years; adjusted odds ratio (OR)=1.51, 95% confidence interval (CI), 1.05‑2.16], but also with diffuse tumors (adjusted OR=1.41, 95% CI, 1.01‑1.96). These data indicate that the polymorphisms of -93G>A, I219V and IVS12‑6T>C are not associated with the risk of gastric cancer. However, hMSH2-118T>C combined with variant genotypes (TC+CC) may confer a potential risk of gastric cancer in the Chinese population.
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1 

Jemal A, Siegel R, Xu J and Ward E: Cancer statistics. CA Cancer J Clin. 60:277–300. 2010.

2 

Afuwape OO, Irabor DO, Ladipo JK and Ayandipo B: A Review of the Current Profile of Gastric Cancer Presentation in the University College Hospital Ibadan, a Tertiary Health Care Institution in the Tropics. J Gastrointest Cancer. Feb, 2011.(Epub ahead of print).

3 

Herszényi L and Tulassay Z: Epidemiology of gastrointestinal and liver tumors. Eur Rev Med Pharmacol Sci. 14:249–258. 2010.

4 

Wang W, Li YF, Sun XW, et al: Prognosis of 980 patients with gastric cancer after surgical resection. Chin J Cancer. 29:923–930. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Arkenau HT: Gastric cancer in the era of molecularly targeted agents: current drug development strategies. J Cancer Res Clin Oncol. 135:855–866. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Aarnio M, Sankila R, Pukkala E, et al: Cancer risk in mutation carriers of DNA-mismatch-repair genes. Int J Cancer. 81:214–218. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Goecke T, Schulmann K, Engel C, et al: Genotype-phenotype comparison of German MLH1 and MSH2 mutation carriers clinically affected with Lynch syndrome: a report by the German HNPCC consortium. J Clin Oncol. 24:4285–4292. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Abdel-Rahman WM, Mecklin JP and Peltomaki P: The genetics of HNPCC: application to diagnosis and screening. Crit Rev Oncol Hematol. 58:208–220. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Liu T: Mutational screening of hMLH1 and hMSH2 that confer inherited colorectal cancer susceptibility using denature gradient gel electrophoresis (DGGE). Methods Mol Biol. 653:193–205. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Vasen HF, Stormorken A, Menko FH, et al: MSH2 mutation carriers are at higher risk of cancer than MLH1 mutation carriers: a study of hereditary nonpolyposis colorectal cancer families. J Clin Oncol. 19:4074–4080. 2001.PubMed/NCBI

11 

Haghighi MM, Javadi GR, Parivar K, Milanizadeh S, Zali N, Fatemi SR and Zali MR: Frequent MSI mononucleotide markers for diagnosis of hereditary nonpolyposis colorectal cancer. Asian Pac J Cancer Prev. 11:1033–1035. 2010.PubMed/NCBI

12 

Scheuner MT, McNeel TS and Freedman AN: Population prevalence of familial cancer and common hereditary cancer syndromes. The 2005 California Health Interview Survey. Genet Med. 12:726–735. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Power DG, Gloglowski E and Lipkin SM: Clinical genetics of hereditary colorectal cancer. Hematol Oncol Clin North Am. 24:837–859. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Sheng X, Zhou HH, Zhou XY, et al: Germline mutation analysis of hPMS2 gene in Chinese families with hereditary nonpolyposis colorectal cancer. World J Gastroenterol. 16:3847–3852. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Corso G, Marrelli D and Roviello F: Familial gastric cancer: update for practice management. Fam Cancer. 10:391–396. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Yamasaki Y, Matsushima M, Tanaka H, et al: Patient with eight metachronous gastrointestinal cancers thought to be hereditary nonpolyposis colorectal cancer (HNPCC). Intern Med. 49:209–213. 2010. View Article : Google Scholar

17 

Capelle LG, Van Grieken NC, Lingsma HF, et al: Risk and epidemiological time trends of gastric cancer in Lynch syndrome carriers in the Netherlands. Gastroenterology. 138:487–492. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Xie J, Guillemette S, Peng M, Gilbert C, Buermeyer A and Cantor SB.: An MLH1 mutation links BACH1/FANCJ to colon cancer, signaling, and insight toward directed therapy. Cancer Prev Res (Phila). 3:1409–1416. 2010. View Article : Google Scholar : PubMed/NCBI

19 

van Roon EH, van Puijenbroek M, Middeldorp A, et al: Early onset MSI-H colon cancer with MLH1 promoter methylation, is there a genetic predisposition? BMC Cancer. 10:1802010.PubMed/NCBI

20 

Allan JM, Shorto J, Adlard J, et al: MLH1 -93G>A promoter polymorphism and risk of mismatch repair deficient colorectal cancer. Int J Cancer. 123:2456–2459. 2008.

21 

Park SH, Lee GY, Jeon HS, et al: -93G-->A polymorphism of hMLH1 and risk of primary lung cancer. Int J Cancer. 112:678–682. 2004.

22 

Wang H, Wang Y, Liu H, et al: Polymorphisms in hMLH1 and risk of early-onset lung cancer in a southeast Chinese population. Lung Cancer. 59:164–170. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Vietri MT, Riegler G, De Paola M, et al: I219V polymorphism in hMLH1 gene in patients affected with ulcerative colitis. Genet Test Mol Biomarkers. 13:193–197. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Trojan J, Zeuzem S, Randolph A, et al: Functional analysis of hMLH1 variants and HNPCC-related mutations using a human expression system. Gastroenterology. 122:211–219. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Bellacosa A: Functional interactions and signaling properties of mammalian DNA mismatch repair proteins. Cell Death Differ. 8:1076–1092. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Jung CY, Choi JE, Park JM, et al: Polymorphisms in the hMSH2 gene and the risk of primary lung cancer. Cancer Epidemiol Biomarkers Prev. 15:762–768. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Worrillow LJ, Travis LB, Smith AG, Sara R, Andrew JS and Christopher PW: An intron splice acceptor polymorphism in hMSH2 and risk of leukemia after treatment with chemotherapeutic alkylating agents. Clin Cancer Res. 9:3012–3020. 2003.PubMed/NCBI

28 

Paz-y-Miño C, Pérez JC, Fiallo BF and Leone PE: A polymorphism in the hMSH2 gene (gIVS12-6T>C) associated with non-Hodgkin lymphomas. Cancer Genet Cytogenet. 133:29–33. 2002.

29 

Palicio M, Blanco I, Tórtola S, et al: Intron splice acceptor site polymorphism in the hMSH2 gene in sporadic and familial colorectal cancer. Br J Cancer. 82:535–537. 2000. View Article : Google Scholar : PubMed/NCBI

30 

Goessl C, Plaschke J, Pistorius S, Hahn M, Frank S and Hampl M: An intronic germline transition in the HNPCC gene hMSH2 is associated with sporadic colorectal cancer. Eur J Cancer. 33:1869–1874. 1997. View Article : Google Scholar : PubMed/NCBI

31 

Brentnall TA, Rubin CE, Crispin DA, et al: A germline substitution in the human MSH2 gene is associated with high-grade dysplasia and cancer in ulcerative colitis. Gastroenterology. 109:151–155. 1995. View Article : Google Scholar : PubMed/NCBI

32 

Cheng H, Sun N, Sun X, et al: Polymorphisms in hMSH2 and hMLH1 and response to platinum-based chemotherapy in advanced non-small-cell lung cancer patients. Acta Biochim Biophys Sin (Shanghai). 42:311–317. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Mrkonjic M, Raptis S, Green RC, et al: MSH2 118T>C and MSH6 159C>T promoter polymorphisms and the risk of colorectal cancer. Carcinogenesis. 28:2575–2580. 2007.

34 

Shin KH, Shin JH, Kim JH and Park JG: Mutational analysis of promoters of mismatch repair genes hMSH2 and hMLH1 in hereditary nonpolyposis colorectal cancer and early onset colorectal cancer patients: identification of three novel germ-line mutations in promoter of the hMSH2 gene. Cancer Res. 62:38–42. 2002.

35 

Vasen HF, Watson P, Mecklin JP and Lynch HT: New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology. 116:1453–1456. 1999. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Xiao X, Gong W, Wang S, Zhang Z, Rui X, Wu G and Ren F: Polymorphisms of mismatch repair gene hMLH1 and hMSH2 and risk of gastric cancer in a Chinese population. Oncol Lett 3: 591-598, 2012.
APA
Xiao, X., Gong, W., Wang, S., Zhang, Z., Rui, X., Wu, G., & Ren, F. (2012). Polymorphisms of mismatch repair gene hMLH1 and hMSH2 and risk of gastric cancer in a Chinese population. Oncology Letters, 3, 591-598. https://doi.org/10.3892/ol.2011.517
MLA
Xiao, X., Gong, W., Wang, S., Zhang, Z., Rui, X., Wu, G., Ren, F."Polymorphisms of mismatch repair gene hMLH1 and hMSH2 and risk of gastric cancer in a Chinese population". Oncology Letters 3.3 (2012): 591-598.
Chicago
Xiao, X., Gong, W., Wang, S., Zhang, Z., Rui, X., Wu, G., Ren, F."Polymorphisms of mismatch repair gene hMLH1 and hMSH2 and risk of gastric cancer in a Chinese population". Oncology Letters 3, no. 3 (2012): 591-598. https://doi.org/10.3892/ol.2011.517
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao X, Gong W, Wang S, Zhang Z, Rui X, Wu G and Ren F: Polymorphisms of mismatch repair gene hMLH1 and hMSH2 and risk of gastric cancer in a Chinese population. Oncol Lett 3: 591-598, 2012.
APA
Xiao, X., Gong, W., Wang, S., Zhang, Z., Rui, X., Wu, G., & Ren, F. (2012). Polymorphisms of mismatch repair gene hMLH1 and hMSH2 and risk of gastric cancer in a Chinese population. Oncology Letters, 3, 591-598. https://doi.org/10.3892/ol.2011.517
MLA
Xiao, X., Gong, W., Wang, S., Zhang, Z., Rui, X., Wu, G., Ren, F."Polymorphisms of mismatch repair gene hMLH1 and hMSH2 and risk of gastric cancer in a Chinese population". Oncology Letters 3.3 (2012): 591-598.
Chicago
Xiao, X., Gong, W., Wang, S., Zhang, Z., Rui, X., Wu, G., Ren, F."Polymorphisms of mismatch repair gene hMLH1 and hMSH2 and risk of gastric cancer in a Chinese population". Oncology Letters 3, no. 3 (2012): 591-598. https://doi.org/10.3892/ol.2011.517
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