Evaluation of whole-body retention of iodine-131 (131I) after postoperative remnant ablation for differentiated thyroid carcinoma – thyroxine withdrawal versus rhTSH administration: A retrospective comparison

  • Authors:
    • Maria Raquel Carvalho
    • Teresa C. Ferreira
    • Valeriano Leite
  • View Affiliations

  • Published online on: December 14, 2011     https://doi.org/10.3892/ol.2011.523
  • Pages: 617-620
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Abstract

Previous studies demonstrated that preparation with recombinant human thyroid-stimulating hormone (rhTSH) for thyroid remnant ablation results in lower extrathyroidal radiation compared to hypothyroidism. The results of 50 radioiodine therapies (RITs) under rhTSH, regarding iodine half-life, were evaluated and compared with 50 RITs performed on patients with hypothyroidism following thyroxine withdrawal. The patients were treated with 3700 MBq (100 mCi) of 131I. Forty‑eight hours after RIT, patients were measured with a radiation detector at a 1-meter (m) distance for evaluation of the effective dose (µSv/h). TSH and thyroglobulin (Tg) maximal values were also compared. rhTSH-stimulated patients had a significantly lower whole-body retention of 131I (8.5±7.3 µSv/h), extrapolated from the measurements of the effective dose at a 1-m distance, compared to endogenously stimulated patients (13.6±8.1 µSv/h; p=0.001). Furthermore, TSH mean and Tg median levels were significantly higher in the rhTSH‑stimulated patients (89.9±15.3 mU/l and 7.7 ng/ml, respectively) compared to the hypothyroid group (59.2±25.1 mU/l and 3.3 ng/ml; p<0.001 and p=0.003, respectively). Compared to thyroid hormone withdrawal, the use of rhTSH prior to RIT was associated with significantly lower whole-body retention of 131I and with greater efficacy in reaching TSH levels greater than 30 mU/l, confirming data previously described.
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March 2012
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Spandidos Publications style
Carvalho MR, Ferreira TC and Leite V: Evaluation of whole-body retention of iodine-131 (131I) after postoperative remnant ablation for differentiated thyroid carcinoma – thyroxine withdrawal versus rhTSH administration: A retrospective comparison. Oncol Lett 3: 617-620, 2012
APA
Carvalho, M.R., Ferreira, T.C., & Leite, V. (2012). Evaluation of whole-body retention of iodine-131 (131I) after postoperative remnant ablation for differentiated thyroid carcinoma – thyroxine withdrawal versus rhTSH administration: A retrospective comparison. Oncology Letters, 3, 617-620. https://doi.org/10.3892/ol.2011.523
MLA
Carvalho, M. R., Ferreira, T. C., Leite, V."Evaluation of whole-body retention of iodine-131 (131I) after postoperative remnant ablation for differentiated thyroid carcinoma – thyroxine withdrawal versus rhTSH administration: A retrospective comparison". Oncology Letters 3.3 (2012): 617-620.
Chicago
Carvalho, M. R., Ferreira, T. C., Leite, V."Evaluation of whole-body retention of iodine-131 (131I) after postoperative remnant ablation for differentiated thyroid carcinoma – thyroxine withdrawal versus rhTSH administration: A retrospective comparison". Oncology Letters 3, no. 3 (2012): 617-620. https://doi.org/10.3892/ol.2011.523