Detection of methylation of the RAR-β gene in patients with non-small cell lung cancer

  • Authors:
    • Xudong Zhao
    • Nianfei Wang
    • Mingjun Zhang
    • Shaoli  Xue
    • Kaihu Shi
    • Zhendong Chen
  • View Affiliations

  • Published online on: December 19, 2011     https://doi.org/10.3892/ol.2011.527
  • Pages: 654-658
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Abstract

The aim of this study was to detect methylation of the RAR-β gene in tissues from non-small cell lung cancer (NSCLC) patients. The methylation of the RAR-β gene in DNA from 80 cases with NSCLC and corresponding non-malignant tissues was tested using methylation-specific polymerase chain reaction (PCR; MSP). The results showed that the total frequency of RAR-β methylation was significantly higher in lung cancer tissues compared to the corresponding non‑malignant tissues (57.5 vs. 17.5%) (P<0.01). However, no significant difference was found in various clinical stages and types of lung cancer (P>0.05). A significant difference was observed in the various pathological types (P<0.05). RAR-β gene methylation is closely correlated with the development process of NSCLC, particularly squamous cell carcinoma.
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March 2012
Volume 3 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhao X, Wang N, Zhang M, Xue S, Shi K and Chen Z: Detection of methylation of the RAR-β gene in patients with non-small cell lung cancer. Oncol Lett 3: 654-658, 2012
APA
Zhao, X., Wang, N., Zhang, M., Xue, S., Shi, K., & Chen, Z. (2012). Detection of methylation of the RAR-β gene in patients with non-small cell lung cancer. Oncology Letters, 3, 654-658. https://doi.org/10.3892/ol.2011.527
MLA
Zhao, X., Wang, N., Zhang, M., Xue, S., Shi, K., Chen, Z."Detection of methylation of the RAR-β gene in patients with non-small cell lung cancer". Oncology Letters 3.3 (2012): 654-658.
Chicago
Zhao, X., Wang, N., Zhang, M., Xue, S., Shi, K., Chen, Z."Detection of methylation of the RAR-β gene in patients with non-small cell lung cancer". Oncology Letters 3, no. 3 (2012): 654-658. https://doi.org/10.3892/ol.2011.527