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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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March 2012 Volume 3 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Detection of methylation of the RAR-β gene in patients with non-small cell lung cancer

  • Authors:
    • Xudong Zhao
    • Nianfei Wang
    • Mingjun Zhang
    • Shaoli  Xue
    • Kaihu Shi
    • Zhendong Chen
  • View Affiliations / Copyright

    Affiliations: Department of Cardiothoracic Surgery, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China, Department of Oncology, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China, Department of Biotechnology, Anhui Medical University, Hefei, Anhui 230032, P.R. China, Department of Oncology, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China
  • Pages: 654-658
    |
    Published online on: December 19, 2011
       https://doi.org/10.3892/ol.2011.527
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Abstract

The aim of this study was to detect methylation of the RAR-β gene in tissues from non-small cell lung cancer (NSCLC) patients. The methylation of the RAR-β gene in DNA from 80 cases with NSCLC and corresponding non-malignant tissues was tested using methylation-specific polymerase chain reaction (PCR; MSP). The results showed that the total frequency of RAR-β methylation was significantly higher in lung cancer tissues compared to the corresponding non‑malignant tissues (57.5 vs. 17.5%) (P<0.01). However, no significant difference was found in various clinical stages and types of lung cancer (P>0.05). A significant difference was observed in the various pathological types (P<0.05). RAR-β gene methylation is closely correlated with the development process of NSCLC, particularly squamous cell carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao X, Wang N, Zhang M, Xue S, Shi K and Chen Z: Detection of methylation of the RAR-β gene in patients with non-small cell lung cancer. Oncol Lett 3: 654-658, 2012.
APA
Zhao, X., Wang, N., Zhang, M., Xue, S., Shi, K., & Chen, Z. (2012). Detection of methylation of the RAR-β gene in patients with non-small cell lung cancer. Oncology Letters, 3, 654-658. https://doi.org/10.3892/ol.2011.527
MLA
Zhao, X., Wang, N., Zhang, M., Xue, S., Shi, K., Chen, Z."Detection of methylation of the RAR-β gene in patients with non-small cell lung cancer". Oncology Letters 3.3 (2012): 654-658.
Chicago
Zhao, X., Wang, N., Zhang, M., Xue, S., Shi, K., Chen, Z."Detection of methylation of the RAR-β gene in patients with non-small cell lung cancer". Oncology Letters 3, no. 3 (2012): 654-658. https://doi.org/10.3892/ol.2011.527
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao X, Wang N, Zhang M, Xue S, Shi K and Chen Z: Detection of methylation of the RAR-β gene in patients with non-small cell lung cancer. Oncol Lett 3: 654-658, 2012.
APA
Zhao, X., Wang, N., Zhang, M., Xue, S., Shi, K., & Chen, Z. (2012). Detection of methylation of the RAR-β gene in patients with non-small cell lung cancer. Oncology Letters, 3, 654-658. https://doi.org/10.3892/ol.2011.527
MLA
Zhao, X., Wang, N., Zhang, M., Xue, S., Shi, K., Chen, Z."Detection of methylation of the RAR-β gene in patients with non-small cell lung cancer". Oncology Letters 3.3 (2012): 654-658.
Chicago
Zhao, X., Wang, N., Zhang, M., Xue, S., Shi, K., Chen, Z."Detection of methylation of the RAR-β gene in patients with non-small cell lung cancer". Oncology Letters 3, no. 3 (2012): 654-658. https://doi.org/10.3892/ol.2011.527
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