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Article

Interaction between cyclooxygenase-2 and insulin-like growth factor in breast cancer: A new field for prevention and treatment

  • Authors:
    • Giuliana Cássia Morrone Taromaru
    • Vilmar Marques de Oliveira
    • Maria  Antonieta Longo Galvão Silva
    • Wagner Ricardo Montor
    • Fabio Bagnoli
    • José Francisco Rinaldi
    • Tsutomu Aoki
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Santa Casa de São Paulo, Faculty of Medical Sciences, São Paulo, Brazil, Department of Pathology, Santa Casa de São Paulo, Faculty of Medical Sciences, São Paulo, Brazil, Department of Physiology, Santa Casa de São Paulo, Faculty of Medical Sciences, São Paulo, Brazil
  • Pages: 682-688
    |
    Published online on: December 21, 2011
       https://doi.org/10.3892/ol.2011.532
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Abstract

The objective of this study was to evaluate the correlation between cyclooxygenase-2 (COX-2) and markers of cell proliferation and apoptosis, including, Bcl-2, Bax, Ki-67 and the type I insulin-like growth factor (IGF) receptor (IGF1-R) in ductal carcinoma in situ (DCIS) and infiltrating ductal carcinoma (IDC), present in the same surgical specimen. A total of 110 cases were evaluated using tissue microarrays. Cases were classified in scores from 0 to 3 according to pre-defined methods. The results showed that the positivity rates were COX-2 in 87% of cases in DCIS and IDC; Bcl-2 in 55% of cases in DCIS and IDC; Bax in 23% of cases in IDC and 19% in DCIS, IGF-1 in 24% of cases in DCIS and IDC; and Ki-67 in 81% of cases in DCIS and IDC. We also observed a positive correlation between the expression of COX-2 and IGF1-R (p=0.045). Our results demonstrate a positive correlation between the expression of COX-2 and IGF1-R in DCIS and IDC, demonstrating that they are involved in breast cancer carcinogenesis. Further studies are required to prove the effectiveness of COX-2 and IGF1-R inhibitors for the prevention and treatment of breast cancer, as well as to explain their mechanism of action.
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Copy and paste a formatted citation
Spandidos Publications style
Morrone Taromaru GC, Marques de Oliveira V, Longo Galvão Silva MA, Montor WR, Bagnoli F, Rinaldi JF and Aoki T: Interaction between cyclooxygenase-2 and insulin-like growth factor in breast cancer: A new field for prevention and treatment. Oncol Lett 3: 682-688, 2012.
APA
Morrone Taromaru, G.C., Marques de Oliveira, V., Longo Galvão Silva, M.A., Montor, W.R., Bagnoli, F., Rinaldi, J.F., & Aoki, T. (2012). Interaction between cyclooxygenase-2 and insulin-like growth factor in breast cancer: A new field for prevention and treatment. Oncology Letters, 3, 682-688. https://doi.org/10.3892/ol.2011.532
MLA
Morrone Taromaru, G. C., Marques de Oliveira, V., Longo Galvão Silva, M. A., Montor, W. R., Bagnoli, F., Rinaldi, J. F., Aoki, T."Interaction between cyclooxygenase-2 and insulin-like growth factor in breast cancer: A new field for prevention and treatment". Oncology Letters 3.3 (2012): 682-688.
Chicago
Morrone Taromaru, G. C., Marques de Oliveira, V., Longo Galvão Silva, M. A., Montor, W. R., Bagnoli, F., Rinaldi, J. F., Aoki, T."Interaction between cyclooxygenase-2 and insulin-like growth factor in breast cancer: A new field for prevention and treatment". Oncology Letters 3, no. 3 (2012): 682-688. https://doi.org/10.3892/ol.2011.532
Copy and paste a formatted citation
x
Spandidos Publications style
Morrone Taromaru GC, Marques de Oliveira V, Longo Galvão Silva MA, Montor WR, Bagnoli F, Rinaldi JF and Aoki T: Interaction between cyclooxygenase-2 and insulin-like growth factor in breast cancer: A new field for prevention and treatment. Oncol Lett 3: 682-688, 2012.
APA
Morrone Taromaru, G.C., Marques de Oliveira, V., Longo Galvão Silva, M.A., Montor, W.R., Bagnoli, F., Rinaldi, J.F., & Aoki, T. (2012). Interaction between cyclooxygenase-2 and insulin-like growth factor in breast cancer: A new field for prevention and treatment. Oncology Letters, 3, 682-688. https://doi.org/10.3892/ol.2011.532
MLA
Morrone Taromaru, G. C., Marques de Oliveira, V., Longo Galvão Silva, M. A., Montor, W. R., Bagnoli, F., Rinaldi, J. F., Aoki, T."Interaction between cyclooxygenase-2 and insulin-like growth factor in breast cancer: A new field for prevention and treatment". Oncology Letters 3.3 (2012): 682-688.
Chicago
Morrone Taromaru, G. C., Marques de Oliveira, V., Longo Galvão Silva, M. A., Montor, W. R., Bagnoli, F., Rinaldi, J. F., Aoki, T."Interaction between cyclooxygenase-2 and insulin-like growth factor in breast cancer: A new field for prevention and treatment". Oncology Letters 3, no. 3 (2012): 682-688. https://doi.org/10.3892/ol.2011.532
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