Application of conditional probability analysis to distant metastases from lung cancer

Oikawa,Akihiro; Takahashi,Hideto; Ishikawa,Hiroichi; Kurishima,Koichi; Kagohashi,Katsunori; Satoh,Hiroaki

doi:10.3892/ol.2011.535

March 2012 Volume 3 Issue 3

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March 2012 Volume 3 Issue 3

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Article

Application of conditional probability analysis to distant metastases from lung cancer

Authors:
- Akihiro Oikawa
- Hideto Takahashi
- Hiroichi Ishikawa
- Koichi Kurishima
- Katsunori Kagohashi
- Hiroaki Satoh
View Affiliations / Copyright

Affiliations: Master's Program in Medical Sciences, University of Tsukuba, Ibaraki 310-0015, Japan, Department of Epidemiology and Biostatistics, School of Medicine, University of Tsukuba, Ibaraki 310-0015, Japan, Division of Respiratory Medicine, Tsukuba Medical Center, Ibaraki 310-0015, Japan, Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki 310-0015, Japan, Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Ibaraki 310-0015, Japan
Pages: 629-634
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Published online on: December 23, 2011

https://doi.org/10.3892/ol.2011.535
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Abstract

The aim of this study was to reveal whether there was non-randomness in the occurrence of metastasis and, if the non-randomness was denied, whether there were specific metastatic patterns in lung cancer patients. Patients who presented with pathologically diagnosed lung cancer between January 1986 and March 2009 at our hospitals were included. A statistical method and conditional probability analysis were used to analyze the data. Under the condition of one metastatic organ A (lung, bone, brain, liver or adrenal gland; the 5 most common metastatic organs), we determined the conditional probability of distant metastasis to a specific organ B, which was written as P(B⎪A), and compared it with the probability of distant metastasis P(B). The study group consisted of 1,994 patients. Of the 1,994 patients, 839 (42.1%) had distant metastases at the time of the initial diagnosis of lung cancer. With the exception of the comparisons between P(lung) and P(lung⎪adrenal gland) and between P(adrenal gland) and P(adrenal gland⎪lung), there were statistically significant differences between P(B⎪A) and P(B) in the 5 metastatic organs. In addition, P(B⎪A) and P(C⎪B⎪A) varied according to each organ and P(confined to A), P(confined to A and B) and P(confined to A, B and C) were different in each metastatic organ. In lung cancer patients, distant metastasis occurred non-randomly and there may be certain specific patterns of distant metastasis. The accumulation of knowledge of specific patterns of metastasis may aid the approach to individualized treatments.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Application of conditional probability analysis to distant metastases from lung cancer

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