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Article

Clinical role of pleural effusion MMP-3 levels in malignant pleural mesothelioma

  • Authors:
    • Aki Murakami
    • Chiharu Tabata
    • Rie Tabata
    • Hisaya Okuwa
    • Takashi Nakano
  • View Affiliations / Copyright

    Affiliations: Division of Respiratory Medicine, Department of Internal Medicine, Hyogo College of Medicine, Hyogo 663-8501, Japan
  • Pages: 581-585
    |
    Published online on: December 23, 2011
       https://doi.org/10.3892/ol.2011.536
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Abstract

Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor of mesothelial origin associated with asbestos exposure. MPM exhibits a limited response to conventional chemotherapy and radiotherapy. This, early diagnosis of MPM is essential. Malignant tumor progression requires the destruction of the basement membrane, which is constructed from extracellular matrix (ECM) materials. Various types of human tumor cells are reported to produce ECM-degrading proteases that are important in tumor progression. Among this group of proteolytic enzymes, matrix metalloproteinases (MMPs) are thought to be important due to their wide degrading function. We investigated the pleural effusion MMP-3 levels of patients with MPM and compared them with those of a population with non-malignant pleuritis or lung cancer involving malignant pleural effusion. The pleural effusion MMP-3 concentrations of 52 MPM patients and 67 non-MPM patients were measured. The results showed that the MPM patients had significantly higher pleural effusion MMP-3 levels than the population with non-malignant pleuritis. The overall survival of the MPM patients with lower pleural effusion MMP-3 levels was longer than that of patients with higher pleural effusion MMP-3 levels. Our data therefore suggest a clinical role of pleural effusion MMP-3 levels in malignant pleural mesothelioma.
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Copy and paste a formatted citation
Spandidos Publications style
Murakami A, Tabata C, Tabata R, Okuwa H and Nakano T: Clinical role of pleural effusion MMP-3 levels in malignant pleural mesothelioma. Oncol Lett 3: 581-585, 2012.
APA
Murakami, A., Tabata, C., Tabata, R., Okuwa, H., & Nakano, T. (2012). Clinical role of pleural effusion MMP-3 levels in malignant pleural mesothelioma. Oncology Letters, 3, 581-585. https://doi.org/10.3892/ol.2011.536
MLA
Murakami, A., Tabata, C., Tabata, R., Okuwa, H., Nakano, T."Clinical role of pleural effusion MMP-3 levels in malignant pleural mesothelioma". Oncology Letters 3.3 (2012): 581-585.
Chicago
Murakami, A., Tabata, C., Tabata, R., Okuwa, H., Nakano, T."Clinical role of pleural effusion MMP-3 levels in malignant pleural mesothelioma". Oncology Letters 3, no. 3 (2012): 581-585. https://doi.org/10.3892/ol.2011.536
Copy and paste a formatted citation
x
Spandidos Publications style
Murakami A, Tabata C, Tabata R, Okuwa H and Nakano T: Clinical role of pleural effusion MMP-3 levels in malignant pleural mesothelioma. Oncol Lett 3: 581-585, 2012.
APA
Murakami, A., Tabata, C., Tabata, R., Okuwa, H., & Nakano, T. (2012). Clinical role of pleural effusion MMP-3 levels in malignant pleural mesothelioma. Oncology Letters, 3, 581-585. https://doi.org/10.3892/ol.2011.536
MLA
Murakami, A., Tabata, C., Tabata, R., Okuwa, H., Nakano, T."Clinical role of pleural effusion MMP-3 levels in malignant pleural mesothelioma". Oncology Letters 3.3 (2012): 581-585.
Chicago
Murakami, A., Tabata, C., Tabata, R., Okuwa, H., Nakano, T."Clinical role of pleural effusion MMP-3 levels in malignant pleural mesothelioma". Oncology Letters 3, no. 3 (2012): 581-585. https://doi.org/10.3892/ol.2011.536
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