Successful bortezomib treatment in combination with dexamethasone and thalidomide for previously untreated epidural plasmacytoma

Zeng,Zhiyong; Zheng,Ling; Lin,Junfang; Chen,Junmin

doi:10.3892/ol.2011.539

March 2012 Volume 3 Issue 3

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March 2012 Volume 3 Issue 3

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Article

Successful bortezomib treatment in combination with dexamethasone and thalidomide for previously untreated epidural plasmacytoma

Authors:
- Zhiyong Zeng
- Ling Zheng
- Junfang Lin
- Junmin Chen
View Affiliations / Copyright

Affiliations: Department of Hematology and Rheumatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, P.R. China
Pages: 557-559
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Published online on: December 28, 2011

https://doi.org/10.3892/ol.2011.539
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Abstract

Epidural plasmacytoma is a rare clinical entity of plasma cell neoplasms. The optimal management of extramedullary plasmacytoma remains unclear, particularly for bulky masses. In this study, we report the case of a 35-year-old male who presented with the inability to walk, urinary incontinence and superﬁcial and deep sensory disturbance. Spinal magnetic resonance imaging revealed a large epidural mass compressing the spinal cord at the level of T2-T4. The patient underwent surgical T2-T4 vertebral canal decompression. Histopathological examination and other findings confirmed the diagnosis of extramedullary plasmacytoma. The patient was treated with bortezomib in combination with dexamethasone and thalidomide. Following 4 cycles of chemotherapy, the patient achieved an excellent clinical response. Over 1 year following the initial diagnosis, the patient was in complete remission with no evidence of local relapse or evolution to multiple myeloma. This is the first case of a previously untreated epidural plasmacytoma, which was successfully treated with bortezomib-containing chemotherapy.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Successful bortezomib treatment in combination with dexamethasone and thalidomide for previously untreated epidural plasmacytoma

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