Ovarian cancer complicated by pregnancy: Analysis of 10 cases

Dobashi,Mamiko; Isonishi,Seiji; Morikawa,Asuka; Takahashi,Kazuaki; Ueda,Kazu; Umezawa,Satoshi; Kobayashi,Yoichi; Iwashita,Mitsutoshi; Takechi,Kimihiro; Tanaka,Tadao

doi:10.3892/ol.2011.545

March 2012 Volume 3 Issue 3

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March 2012 Volume 3 Issue 3

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Article

Ovarian cancer complicated by pregnancy: Analysis of 10 cases

Authors:
- Mamiko Dobashi
- Seiji Isonishi
- Asuka Morikawa
- Kazuaki Takahashi
- Kazu Ueda
- Satoshi Umezawa
- Yoichi Kobayashi
- Mitsutoshi Iwashita
- Kimihiro Takechi
- Tadao Tanaka
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Affiliations: Department of Obstetrics/Gynecology, Jikei Daisan Hospital, Komae-shi, Tokyo 201-8601, Japan, Department of Obstetrics and Gynecology, Musashino Red Hospital, Musashino-shi, Tokyo 180-8610, Japan, Department of Obstetrics and Gynecology, Kyorin University Hospital, Mitaka-shi, Tokyo 181-0004, Japan, Department of Obstetrics and Gynecology, Showa General Hospital, Kodaira-shi, Tokyo 187-8510, Japan, Department of Obstetrics/Gynecology, Jikei University School of Medicine, Minato-ku, Tokyo 105-8461, Japan
Pages: 577-580
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Published online on: December 29, 2011

https://doi.org/10.3892/ol.2011.545
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Abstract

The objective of this study was to ascertain the evidence on ovarian cancer during pregnancy and compile recommendations derived from this information. This was a retrospective study, based on clinical histories from patients diagnosed and treated at 4 independent hospitals for ovarian cancer during pregnancy, between 1992 and 2009. The median age at diagnosis was 30 years (range, 24-41). Out of 10 cases of ovarian cancer, 2 patients showed either bleeding or abdominal pain, while 8 patients were asymptomatic. All 10 cases were diagnosed via ultrasound, and the masses were detected in the first trimester in 7 patients and in the second trimester in 2 patients. Of the diagnosed tumors, 8 cases were epithelial tumors including 6 adenocarcinomas and 2 borderline tumors, and 2 germ cell tumors. The primary ovarian malignancies were at stage I of the disease. Unilateral salpingo-oophorectomy was performed in 9 patients and cystectomy was performed in one patient. Chemotherapy was administered to 4 patients, in 1 case during pregnancy. Neonatal outcome analysis showed a full- or pre-term delivery in 6 cases, abortion in 1 case and therapeutic termination in 3 cases. The majority of cases of ovarian cancer in pregnancy were incidentally detected by ultrasound at an early stage, resulting in good prognosis for the mother and the neonate.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Ovarian cancer complicated by pregnancy: Analysis of 10 cases

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