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Article

Molecular pathological diagnosis for early esophageal cancer in Kazakh patients

  • Authors:
    • Idiris Awut
    • Madiniyet Niyaz
    • Hadeti Biekemitoufu
    • Zhu Zhang
    • Ilyar Sheyhedin
    • Wen Hao
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China, Xinjiang Esophageal Cancer Research Institute, Center of Medical Research, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China, Department of Pathology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China
  • Pages: 549-553
    |
    Published online on: December 30, 2011
       https://doi.org/10.3892/ol.2011.547
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Abstract

Chromosome abnormalities in cancer cells occur early in carcinogenesis. We employed DNA probes for the detection of cancer cells in surgical specimens in Kazakh patients with suspected esophageal carcinoma, to analyze the application of this technique during the early diagnosis of esophageal cancer. Comparative analysis was used to compare the results of pathological diagnosis with the results of FISH. We performed esophagofiberscopic biopsy examinations in 50 Kazakh patients with suspected esophageal carcinoma, including 40 males and 10 females, with an average age of 56.8 years. The final diagnosis was esophageal squamous cell carcinoma in 47 patients, and adenocarcinoma, mucinous carcinoma and small cell carcinoma in one patient each. The pathological findings of the biopsy were positive in 45 cases, and false-negative in 5. The sensitivity and specificity of pathological diagnosis were 87.2 and 100%, respectively. Using FISH to examine the same tissues, we found that 48 cases showed aberrant copy numbers in either chromosome 3 or 17, and 2 cases were false-negative, with a sensitivity and specificity of 94.8 and 100%, respectively. The copy numbers of centromeres in chromosome 3 were significantly higher than the copy numbers of centromeres in chromosome 17 (P=0.0001). Compared with biopsy pathology, the FISH test was more sensitive. Being an objective and qualitative method, the technology of molecular pathological diagnosis may effectively increase the early diagnostic rate of esophageal cancer. In addition, the centromere probe in chromosome 3 may be the most sensitive probe for the diagnosis of esophageal cancer in Kazakh patients.
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Copy and paste a formatted citation
Spandidos Publications style
Awut I, Niyaz M, Biekemitoufu H, Zhang Z, Sheyhedin I and Hao W: Molecular pathological diagnosis for early esophageal cancer in Kazakh patients. Oncol Lett 3: 549-553, 2012.
APA
Awut, I., Niyaz, M., Biekemitoufu, H., Zhang, Z., Sheyhedin, I., & Hao, W. (2012). Molecular pathological diagnosis for early esophageal cancer in Kazakh patients. Oncology Letters, 3, 549-553. https://doi.org/10.3892/ol.2011.547
MLA
Awut, I., Niyaz, M., Biekemitoufu, H., Zhang, Z., Sheyhedin, I., Hao, W."Molecular pathological diagnosis for early esophageal cancer in Kazakh patients". Oncology Letters 3.3 (2012): 549-553.
Chicago
Awut, I., Niyaz, M., Biekemitoufu, H., Zhang, Z., Sheyhedin, I., Hao, W."Molecular pathological diagnosis for early esophageal cancer in Kazakh patients". Oncology Letters 3, no. 3 (2012): 549-553. https://doi.org/10.3892/ol.2011.547
Copy and paste a formatted citation
x
Spandidos Publications style
Awut I, Niyaz M, Biekemitoufu H, Zhang Z, Sheyhedin I and Hao W: Molecular pathological diagnosis for early esophageal cancer in Kazakh patients. Oncol Lett 3: 549-553, 2012.
APA
Awut, I., Niyaz, M., Biekemitoufu, H., Zhang, Z., Sheyhedin, I., & Hao, W. (2012). Molecular pathological diagnosis for early esophageal cancer in Kazakh patients. Oncology Letters, 3, 549-553. https://doi.org/10.3892/ol.2011.547
MLA
Awut, I., Niyaz, M., Biekemitoufu, H., Zhang, Z., Sheyhedin, I., Hao, W."Molecular pathological diagnosis for early esophageal cancer in Kazakh patients". Oncology Letters 3.3 (2012): 549-553.
Chicago
Awut, I., Niyaz, M., Biekemitoufu, H., Zhang, Z., Sheyhedin, I., Hao, W."Molecular pathological diagnosis for early esophageal cancer in Kazakh patients". Oncology Letters 3, no. 3 (2012): 549-553. https://doi.org/10.3892/ol.2011.547
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