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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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April 2012 Volume 3 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

HPV-16/18 detection does not affect the prognosis of head and neck squamous cell carcinoma in younger and older patients

  • Authors:
    • Luciano Marques-Silva
    • Lucyana Conceição Farias
    • Carlos Alberto de Carvalho Fraga
    • Marcos Vinícius Macedo de Oliveira
    • Cláudio Marcelo Cardos
    • Thiago Fonseca-Silva
    • Carolina Cavalieri Gomes
    • Alfredo Maurício Batista De-Paula
    • Ricardo Santiago Gomez
    • André Luiz Sena Guimarães

  • View Affiliations / Copyright

    Affiliations: Department of Clinical Surgery and Oral Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, Department of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Brazil, Department of Medicine, Universidade Estadual de Montes Claros, Montes Claros, Brazil, Department of Pathology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
  • Pages: 945-949
    |
    Published online on: February 1, 2012
       https://doi.org/10.3892/ol.2012.588
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Abstract

Recently, high-risk human papillomavirus (HPV) has emerged as a possible agent associated with head and neck squamous cell carcinoma (HNSCC) in younger patients. Therefore, the purpose of the present study was to assess the effect of age on the distribution of HPV-16/18 in HNSCC, together with the impact of the virus on patient prognosis. A longitudinal prospective study was used adjusted for age, gender, TNM staging, smoking status and alcohol consumption. HPV was detected by PCR with consensus primers. Results showed there was no difference in the frequency of HPV-16/18 positivity when younger patients were compared to the older patients. No association was found among high-risk HPV positivity, gender, smoking habit and anatomical site. High-risk HPV was associated with advanced TNM in bivariate analyses; however, it did not impact on survival. Only TNM staging was associated with risk of mortality. Our study supports the theory that age does not affect the presence of HPV-16/18 in HNSCC and has no impact on patient prognosis. The incidence of HNSCC among patients under the age of 45 years is reportedly on the increase worldwide. The factors associated with HNSCC in younger adults are not well established. Findings of this study indicate that HPV-16/18 may not play a role in HNSCC patients under the age of 45 years.

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Copy and paste a formatted citation
Spandidos Publications style
Marques-Silva L, Conceição Farias L, de Carvalho Fraga CA, Macedo de Oliveira MV, Cardos CM, Fonseca-Silva T, Cavalieri Gomes C, Batista De-Paula AM, Gomez RS, Sena Guimarães AL, Sena Guimarães AL, et al: HPV-16/18 detection does not affect the prognosis of head and neck squamous cell carcinoma in younger and older patients. Oncol Lett 3: 945-949, 2012.
APA
Marques-Silva, L., Conceição Farias, L., de Carvalho Fraga, C.A., Macedo de Oliveira, M.V., Cardos, C.M., Fonseca-Silva, T. ... Sena Guimarães, A.L. (2012). HPV-16/18 detection does not affect the prognosis of head and neck squamous cell carcinoma in younger and older patients. Oncology Letters, 3, 945-949. https://doi.org/10.3892/ol.2012.588
MLA
Marques-Silva, L., Conceição Farias, L., de Carvalho Fraga, C. A., Macedo de Oliveira, M. V., Cardos, C. M., Fonseca-Silva, T., Cavalieri Gomes, C., Batista De-Paula, A. M., Gomez, R. S., Sena Guimarães, A. L."HPV-16/18 detection does not affect the prognosis of head and neck squamous cell carcinoma in younger and older patients". Oncology Letters 3.4 (2012): 945-949.
Chicago
Marques-Silva, L., Conceição Farias, L., de Carvalho Fraga, C. A., Macedo de Oliveira, M. V., Cardos, C. M., Fonseca-Silva, T., Cavalieri Gomes, C., Batista De-Paula, A. M., Gomez, R. S., Sena Guimarães, A. L."HPV-16/18 detection does not affect the prognosis of head and neck squamous cell carcinoma in younger and older patients". Oncology Letters 3, no. 4 (2012): 945-949. https://doi.org/10.3892/ol.2012.588
Copy and paste a formatted citation
x
Spandidos Publications style
Marques-Silva L, Conceição Farias L, de Carvalho Fraga CA, Macedo de Oliveira MV, Cardos CM, Fonseca-Silva T, Cavalieri Gomes C, Batista De-Paula AM, Gomez RS, Sena Guimarães AL, Sena Guimarães AL, et al: HPV-16/18 detection does not affect the prognosis of head and neck squamous cell carcinoma in younger and older patients. Oncol Lett 3: 945-949, 2012.
APA
Marques-Silva, L., Conceição Farias, L., de Carvalho Fraga, C.A., Macedo de Oliveira, M.V., Cardos, C.M., Fonseca-Silva, T. ... Sena Guimarães, A.L. (2012). HPV-16/18 detection does not affect the prognosis of head and neck squamous cell carcinoma in younger and older patients. Oncology Letters, 3, 945-949. https://doi.org/10.3892/ol.2012.588
MLA
Marques-Silva, L., Conceição Farias, L., de Carvalho Fraga, C. A., Macedo de Oliveira, M. V., Cardos, C. M., Fonseca-Silva, T., Cavalieri Gomes, C., Batista De-Paula, A. M., Gomez, R. S., Sena Guimarães, A. L."HPV-16/18 detection does not affect the prognosis of head and neck squamous cell carcinoma in younger and older patients". Oncology Letters 3.4 (2012): 945-949.
Chicago
Marques-Silva, L., Conceição Farias, L., de Carvalho Fraga, C. A., Macedo de Oliveira, M. V., Cardos, C. M., Fonseca-Silva, T., Cavalieri Gomes, C., Batista De-Paula, A. M., Gomez, R. S., Sena Guimarães, A. L."HPV-16/18 detection does not affect the prognosis of head and neck squamous cell carcinoma in younger and older patients". Oncology Letters 3, no. 4 (2012): 945-949. https://doi.org/10.3892/ol.2012.588
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