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Article

Fertility-sparing treatment using medroxyprogesterone acetate for endometrial carcinoma

  • Authors:
    • Hiroyuki Fujiwara
    • Toshiko Jobo
    • Yuji Takei
    • Yasushi Saga
    • Manami Imai
    • Tsutomu Arai
    • Akiyo Taneichi
    • Shizuo Machida
    • Yoshifumi Takahashi
    • Mitsuaki Suzuki
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Jichi Medical University, Shimotsuke, Tochigi 329-0498, Japan, Department of Obstetrics and Gynecology, Kitasato University School of Medicine, Sagamihara, Kanagawa 252‑0374, Japan
  • Pages: 1002-1006
    |
    Published online on: February 10, 2012
       https://doi.org/10.3892/ol.2012.602
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Abstract

The purpose of this study was to present the results of fertility-sparing treatment using medroxyprogesterone acetate (MPA) for endometrial carcinoma (EC), and to clarify patient characteristics by investigating patient background factors. A total of 59 patients with EC, who received MPA as fertility‑sparing therapy at two institutions over a 21-year period between 1987 and 2008, were studied retrospectively. Patients were administered oral MPA at 400-600 mg/day for 16-24 weeks as long as they responded. Endometrial tissue was assessed twice, at 8-12 weeks (during treatment) and shortly after treatment. The overall complete response (CR) rate was 71%. A total of 22 (52%) of 42 responders later developed relapse. A total of 19 cases became pregnant, and 25 infants were born. Eighty percent of recurrences occurred within 2 years. For stages Ⅰa and Ⅰb-Ⅱa (FIGO, 1988), initial CR rates were 80.0 and 42.9%, respectively (p<0.01), demonstrating a significant difference. Total hysterectomy was performed for 26 patients (44%) due to recurrence or failure to respond to the initial treatment. Among these 26 patients, postoperative stages were more advanced in 10 patients (38%). The grade advanced (became more poorly differentiated) postoperatively in 2 patients (8%). Premenopausal females with EC can be treated successfully with MPA, however patients should be informed of the risks and limitations of this conservative treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Fujiwara H, Jobo T, Takei Y, Saga Y, Imai M, Arai T, Taneichi A, Machida S, Takahashi Y, Suzuki M, Suzuki M, et al: Fertility-sparing treatment using medroxyprogesterone acetate for endometrial carcinoma. Oncol Lett 3: 1002-1006, 2012.
APA
Fujiwara, H., Jobo, T., Takei, Y., Saga, Y., Imai, M., Arai, T. ... Suzuki, M. (2012). Fertility-sparing treatment using medroxyprogesterone acetate for endometrial carcinoma. Oncology Letters, 3, 1002-1006. https://doi.org/10.3892/ol.2012.602
MLA
Fujiwara, H., Jobo, T., Takei, Y., Saga, Y., Imai, M., Arai, T., Taneichi, A., Machida, S., Takahashi, Y., Suzuki, M."Fertility-sparing treatment using medroxyprogesterone acetate for endometrial carcinoma". Oncology Letters 3.5 (2012): 1002-1006.
Chicago
Fujiwara, H., Jobo, T., Takei, Y., Saga, Y., Imai, M., Arai, T., Taneichi, A., Machida, S., Takahashi, Y., Suzuki, M."Fertility-sparing treatment using medroxyprogesterone acetate for endometrial carcinoma". Oncology Letters 3, no. 5 (2012): 1002-1006. https://doi.org/10.3892/ol.2012.602
Copy and paste a formatted citation
x
Spandidos Publications style
Fujiwara H, Jobo T, Takei Y, Saga Y, Imai M, Arai T, Taneichi A, Machida S, Takahashi Y, Suzuki M, Suzuki M, et al: Fertility-sparing treatment using medroxyprogesterone acetate for endometrial carcinoma. Oncol Lett 3: 1002-1006, 2012.
APA
Fujiwara, H., Jobo, T., Takei, Y., Saga, Y., Imai, M., Arai, T. ... Suzuki, M. (2012). Fertility-sparing treatment using medroxyprogesterone acetate for endometrial carcinoma. Oncology Letters, 3, 1002-1006. https://doi.org/10.3892/ol.2012.602
MLA
Fujiwara, H., Jobo, T., Takei, Y., Saga, Y., Imai, M., Arai, T., Taneichi, A., Machida, S., Takahashi, Y., Suzuki, M."Fertility-sparing treatment using medroxyprogesterone acetate for endometrial carcinoma". Oncology Letters 3.5 (2012): 1002-1006.
Chicago
Fujiwara, H., Jobo, T., Takei, Y., Saga, Y., Imai, M., Arai, T., Taneichi, A., Machida, S., Takahashi, Y., Suzuki, M."Fertility-sparing treatment using medroxyprogesterone acetate for endometrial carcinoma". Oncology Letters 3, no. 5 (2012): 1002-1006. https://doi.org/10.3892/ol.2012.602
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