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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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May 2012 Volume 3 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Expression of the TIMP2 gene is not regulated by promoter hypermethylation in the Caski cell line

  • Authors:
    • Gaurav Parashar
    • Neena Capalash
  • View Affiliations / Copyright

    Affiliations: Department of Biotechnology, Panjab University, Chandigarh, India
  • Pages: 1079-1082
    |
    Published online on: February 13, 2012
       https://doi.org/10.3892/ol.2012.608
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Abstract

Promoter hypermethylation has been linked to loss of expression of tumor suppressor genes in various types of tumors. A strong reciprocal correlation between promoter hypermethylation and expression of the TIMP2 gene was observed in the Caski cell line. The TIMP2 promoter was found to be methylated within the 1919 and 1987 region (-325 to -257), relative to the transcription start site through methylation-specific PCR in the HeLa, SiHa and Caski cervical cancer cell lines. However, a reverse transcription PCR analysis of the TIMP2 gene confirmed a normal expression in the HeLa and SiHa cell lines with a high expression in the Caski cell line, indicating that expression of the TIMP2 gene is independent of methylation of CpG sites located within the -325 to -257 region of the TIMP2 promoter, relative to the transcription start site.
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Copy and paste a formatted citation
Spandidos Publications style
Parashar G and Capalash N: Expression of the TIMP2 gene is not regulated by promoter hypermethylation in the Caski cell line. Oncol Lett 3: 1079-1082, 2012.
APA
Parashar, G., & Capalash, N. (2012). Expression of the TIMP2 gene is not regulated by promoter hypermethylation in the Caski cell line. Oncology Letters, 3, 1079-1082. https://doi.org/10.3892/ol.2012.608
MLA
Parashar, G., Capalash, N."Expression of the TIMP2 gene is not regulated by promoter hypermethylation in the Caski cell line". Oncology Letters 3.5 (2012): 1079-1082.
Chicago
Parashar, G., Capalash, N."Expression of the TIMP2 gene is not regulated by promoter hypermethylation in the Caski cell line". Oncology Letters 3, no. 5 (2012): 1079-1082. https://doi.org/10.3892/ol.2012.608
Copy and paste a formatted citation
x
Spandidos Publications style
Parashar G and Capalash N: Expression of the TIMP2 gene is not regulated by promoter hypermethylation in the Caski cell line. Oncol Lett 3: 1079-1082, 2012.
APA
Parashar, G., & Capalash, N. (2012). Expression of the TIMP2 gene is not regulated by promoter hypermethylation in the Caski cell line. Oncology Letters, 3, 1079-1082. https://doi.org/10.3892/ol.2012.608
MLA
Parashar, G., Capalash, N."Expression of the TIMP2 gene is not regulated by promoter hypermethylation in the Caski cell line". Oncology Letters 3.5 (2012): 1079-1082.
Chicago
Parashar, G., Capalash, N."Expression of the TIMP2 gene is not regulated by promoter hypermethylation in the Caski cell line". Oncology Letters 3, no. 5 (2012): 1079-1082. https://doi.org/10.3892/ol.2012.608
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