Open Access

The clinical usefulness of urinary N1,N12-diacetylspermine (DiAcSpm) levels as a tumor marker in patients with colorectal cancer

  • Authors:
    • Yoshifumi Nakayama
    • Takayuki Torigoe
    • Noritaka Minagawa
    • Koji Yamaguchi
  • View Affiliations

  • Published online on: February 29, 2012     https://doi.org/10.3892/ol.2012.625
  • Pages: 970-974
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Abstract

The aim of this study was to evaluate the usefulness of urinary N1,N12‑diacetylspermine (DiAcSpm) measured by the colloidal gold aggregation method as a tumor marker for colorectal cancer (CRC). The preoperative urine of 113 CRC patients was collected, and the urinary DiAcSpm was measured by a reagent kit for DiAcSpm determination based on colloidal gold aggregation using automatic biochemical analyzers. The urinary DiAcSpm levels significantly correlated with distant metastasis and Tumor‑Node-Metastasis (TNM) stage. The positive rates of urinary DiAcSpm were significantly higher than those of serum carcinoembryonic antigen (CEA) or cancer antigen 19-9 (CA19-9) in stages 0+Ⅰ, II, III and IV. The positive rates of urinary DiAcSpm were also significantly higher than those of serum CEA or CA19-9 in the early and advanced CRC groups according to the Japan Classification of Colorectal Cancer. Therefore, urinary DiAcSpm, measured by a reagent kit for DiAcSpm determination based on colloidal gold aggregation, may be useful as a non-invasive tumor marker in patients with CRC.
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May 2012
Volume 3 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Nakayama Y, Torigoe T, Minagawa N and Yamaguchi K: The clinical usefulness of urinary N1,N12-diacetylspermine (DiAcSpm) levels as a tumor marker in patients with colorectal cancer. Oncol Lett 3: 970-974, 2012
APA
Nakayama, Y., Torigoe, T., Minagawa, N., & Yamaguchi, K. (2012). The clinical usefulness of urinary N1,N12-diacetylspermine (DiAcSpm) levels as a tumor marker in patients with colorectal cancer. Oncology Letters, 3, 970-974. https://doi.org/10.3892/ol.2012.625
MLA
Nakayama, Y., Torigoe, T., Minagawa, N., Yamaguchi, K."The clinical usefulness of urinary N1,N12-diacetylspermine (DiAcSpm) levels as a tumor marker in patients with colorectal cancer". Oncology Letters 3.5 (2012): 970-974.
Chicago
Nakayama, Y., Torigoe, T., Minagawa, N., Yamaguchi, K."The clinical usefulness of urinary N1,N12-diacetylspermine (DiAcSpm) levels as a tumor marker in patients with colorectal cancer". Oncology Letters 3, no. 5 (2012): 970-974. https://doi.org/10.3892/ol.2012.625