The pathobiological features of gastrointestinal cancers (Review)

  • Authors:
    • Xue Yang
    • Yasuo Takano
    • Hua-Chuan Zheng
  • View Affiliations

  • Published online on: March 1, 2012     https://doi.org/10.3892/ol.2012.628
  • Pages: 961-969
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Abstract

Gastrointestinal adenocarcinoma (GIA) is a common malignant disease worldwide. Its tumorigenesis and progression is a multistage process with the involvement of a multifactorial etiology. Knowledge regarding altered expression of these genes during carcinogenesis may not only provide information about the molecular events during the initiation and progression of cancer, but may also result in the discovery of biological markers for the evaluation of cancer diagnosis and prognosis. In this review, we assessed molecular markers of pathogenesis, invasion, metastasis and prognosis, such as tumor suppressor and metastasis suppressor genes, and angiogenesis, cell adhesion, cell mobility, ER stress, mucin production, threonine protein kinase and REG family protein expression, by the establishment of tissue microarray (TMA) of GIA and immuno­histochemistry (IHC) by intermittent microwave irradiation and in situ hybridization (ISH). Finally, we characterized the pathobiological features of Lauren's and WHO subtypes. It was found that the aberrant and cell‑specific expression of these molecules is important in the malignant transformation of gastrointestinal epithelium and subsequent progression. These molecules also underlie the histogenic mechanisms of gastric carcinoma according to Lauren's and WHO classification. The combination of TMA, IHC and ISH may be widely applied to screen for molecular markers in GIA.
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May 2012
Volume 3 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yang X, Takano Y and Zheng H: The pathobiological features of gastrointestinal cancers (Review). Oncol Lett 3: 961-969, 2012
APA
Yang, X., Takano, Y., & Zheng, H. (2012). The pathobiological features of gastrointestinal cancers (Review). Oncology Letters, 3, 961-969. https://doi.org/10.3892/ol.2012.628
MLA
Yang, X., Takano, Y., Zheng, H."The pathobiological features of gastrointestinal cancers (Review)". Oncology Letters 3.5 (2012): 961-969.
Chicago
Yang, X., Takano, Y., Zheng, H."The pathobiological features of gastrointestinal cancers (Review)". Oncology Letters 3, no. 5 (2012): 961-969. https://doi.org/10.3892/ol.2012.628