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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Article

Nuclear Aurora B and cytoplasmic Survivin expression is involved in lymph node metastasis of colorectal cancer

  • Authors:
    • Handan Tuncel
    • Fumio Shimamoto
    • Hiroshi Kaneko
    • Eriko  Aoki
    • Hiroshi Jikihara
    • Shiro Nakai
    • Takashi Takata
    • Masaaki Tatsuka
  • View Affiliations / Copyright

    Affiliations: Department of Biophysics, Cerrahpasa Medical Faculty, Istanbul University, Fatih, Istanbul 34303, Turkey, Department of Health Sciences, Faculty of Human Culture and Science, Prefectural University of Hiroshima, Minami-ku, Hiroshima 734‑8558, Japan, Department of Surgery, Hiroshima Memorial Hospital, Naka-ku, Hiroshima 730‑0802, Japan, Department of Oral and Maxillofacial Pathobiology, Division of Frontier Medical Science, Hiroshima University, Graduate School, Minami-ku, Hiroshima 734-8553, Japan, Department of Life Science, Faculty of Life Environmental Science, Prefectural University of Hiroshima, Shobara, Hiroshima 727-0023, Japan
  • Pages: 1109-1114
    |
    Published online on: March 6, 2012
       https://doi.org/10.3892/ol.2012.633
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Abstract

The chromosomal passenger complex (CPC) is a key regulator of chromosome segregation and cytokinesis, and consists of Aurora B kinase, INCENP, Survivin and Borealin. Aurora B is a member of a family of serine/threonine protein kinases, and Survivin belongs to the inhibitors of apoptosis (IAP) gene family, and is also a member of the CPC family. Aurora B and Survivin have also been reported to be overexpressed in various human cancers; however, as yet no studies have investigated the co-expression of Survivin and Aurora B in colorectal carcinoma. Therefore, in the present study, the correlation between Aurora B and Survivin expression was investigated using immunohistochemistry and the associated pathological features in colorectal carcinoma were analyzed. Our present findings showed that nuclear Aurora B and cytoplasmic Survivin expression are strongly associated with and involved in lymph node metastasis in colorectal cancer. Therefore, we suggest that nuclear Aurora B and cytoplasmic Survivin are useful diagnostic markers and therapeutic targets in colorectal carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Tuncel H, Shimamoto F, Kaneko H, Aoki E, Jikihara H, Nakai S, Takata T and Tatsuka M: Nuclear Aurora B and cytoplasmic Survivin expression is involved in lymph node metastasis of colorectal cancer. Oncol Lett 3: 1109-1114, 2012.
APA
Tuncel, H., Shimamoto, F., Kaneko, H., Aoki, E., Jikihara, H., Nakai, S. ... Tatsuka, M. (2012). Nuclear Aurora B and cytoplasmic Survivin expression is involved in lymph node metastasis of colorectal cancer. Oncology Letters, 3, 1109-1114. https://doi.org/10.3892/ol.2012.633
MLA
Tuncel, H., Shimamoto, F., Kaneko, H., Aoki, E., Jikihara, H., Nakai, S., Takata, T., Tatsuka, M."Nuclear Aurora B and cytoplasmic Survivin expression is involved in lymph node metastasis of colorectal cancer". Oncology Letters 3.5 (2012): 1109-1114.
Chicago
Tuncel, H., Shimamoto, F., Kaneko, H., Aoki, E., Jikihara, H., Nakai, S., Takata, T., Tatsuka, M."Nuclear Aurora B and cytoplasmic Survivin expression is involved in lymph node metastasis of colorectal cancer". Oncology Letters 3, no. 5 (2012): 1109-1114. https://doi.org/10.3892/ol.2012.633
Copy and paste a formatted citation
x
Spandidos Publications style
Tuncel H, Shimamoto F, Kaneko H, Aoki E, Jikihara H, Nakai S, Takata T and Tatsuka M: Nuclear Aurora B and cytoplasmic Survivin expression is involved in lymph node metastasis of colorectal cancer. Oncol Lett 3: 1109-1114, 2012.
APA
Tuncel, H., Shimamoto, F., Kaneko, H., Aoki, E., Jikihara, H., Nakai, S. ... Tatsuka, M. (2012). Nuclear Aurora B and cytoplasmic Survivin expression is involved in lymph node metastasis of colorectal cancer. Oncology Letters, 3, 1109-1114. https://doi.org/10.3892/ol.2012.633
MLA
Tuncel, H., Shimamoto, F., Kaneko, H., Aoki, E., Jikihara, H., Nakai, S., Takata, T., Tatsuka, M."Nuclear Aurora B and cytoplasmic Survivin expression is involved in lymph node metastasis of colorectal cancer". Oncology Letters 3.5 (2012): 1109-1114.
Chicago
Tuncel, H., Shimamoto, F., Kaneko, H., Aoki, E., Jikihara, H., Nakai, S., Takata, T., Tatsuka, M."Nuclear Aurora B and cytoplasmic Survivin expression is involved in lymph node metastasis of colorectal cancer". Oncology Letters 3, no. 5 (2012): 1109-1114. https://doi.org/10.3892/ol.2012.633
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