Nuclear Aurora B and cytoplasmic Survivin expression is involved in lymph node metastasis of colorectal cancer

Tuncel,Handan; Shimamoto,Fumio; Kaneko,Hiroshi; Aoki,Eriko; Jikihara,Hiroshi; Nakai,Shiro; Takata,Takashi; Tatsuka,Masaaki

doi:10.3892/ol.2012.633

Nuclear Aurora B and cytoplasmic Survivin expression is involved in lymph node metastasis of colorectal cancer

Authors:
- Handan Tuncel
- Fumio Shimamoto
- Hiroshi Kaneko
- Eriko Aoki
- Hiroshi Jikihara
- Shiro Nakai
- Takashi Takata
- Masaaki Tatsuka
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Affiliations: Department of Biophysics, Cerrahpasa Medical Faculty, Istanbul University, Fatih, Istanbul 34303, Turkey, Department of Health Sciences, Faculty of Human Culture and Science, Prefectural University of Hiroshima, Minami-ku, Hiroshima 734‑8558, Japan, Department of Surgery, Hiroshima Memorial Hospital, Naka-ku, Hiroshima 730‑0802, Japan, Department of Oral and Maxillofacial Pathobiology, Division of Frontier Medical Science, Hiroshima University, Graduate School, Minami-ku, Hiroshima 734-8553, Japan, Department of Life Science, Faculty of Life Environmental Science, Prefectural University of Hiroshima, Shobara, Hiroshima 727-0023, Japan
Published online on: March 6, 2012 https://doi.org/10.3892/ol.2012.633
Pages: 1109-1114

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Abstract

The chromosomal passenger complex (CPC) is a key regulator of chromosome segregation and cytokinesis, and consists of Aurora B kinase, INCENP, Survivin and Borealin. Aurora B is a member of a family of serine/threonine protein kinases, and Survivin belongs to the inhibitors of apoptosis (IAP) gene family, and is also a member of the CPC family. Aurora B and Survivin have also been reported to be overexpressed in various human cancers; however, as yet no studies have investigated the co-expression of Survivin and Aurora B in colorectal carcinoma. Therefore, in the present study, the correlation between Aurora B and Survivin expression was investigated using immunohistochemistry and the associated pathological features in colorectal carcinoma were analyzed. Our present findings showed that nuclear Aurora B and cytoplasmic Survivin expression are strongly associated with and involved in lymph node metastasis in colorectal cancer. Therefore, we suggest that nuclear Aurora B and cytoplasmic Survivin are useful diagnostic markers and therapeutic targets in colorectal carcinoma.

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1	Adams RR, Carmena M and Earnshaw WC: Chromosomal passengers and the (aurora) ABCs of mitosis. Trends Cell Biol. 11:49–54. 2001. View Article : Google Scholar : PubMed/NCBI
2	Tatsuka M, Katayama H, Ota T, Tanaka T, Odashima S, Suzuki F and Terada Y: Multinuclearity and increased ploidy caused by overexpression of the Aurora B and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells. Cancer Res. 58:4811–4816. 1998.PubMed/NCBI
3	Kurai M, Shiozawa T and Shih HC: Expression of Aurora kinases A and B in normal, hyperplastic, and malignant human endometrium: Aurora B as a predictor for poor prognosis in endometrial carcinoma. Hum Pathol. 36:1281–1288. 2005. View Article : Google Scholar : PubMed/NCBI
4	Lee EC, Frolov A, Li R, Ayala G and Greenberg NM: Targeting Aurora kinases for the treatment of prostate cancer. Cancer Res. 66:4996–5002. 2001. View Article : Google Scholar : PubMed/NCBI
5	Sorrentino R, Libertini S, Pallante PL, Troncone G, Palombini L, Bavetsias V, Spalletti-Cernia D, Laccetti P, Linardopoulos S, Chieffi P, Fusco A and Portella G: Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation. J Clin Endocrinol Metab. 90:928–935. 2005. View Article : Google Scholar : PubMed/NCBI
6	Qi G, Ogawa I, Kudo Y, Miyauchi M, Siriwardena BSMS, Shimamoto F, Tatsuka M and Takata T: Aurora-B expression and its correlation with cell proliferation and metastasis in oral cancer. Virchows Arch. 450:297–302. 2007. View Article : Google Scholar : PubMed/NCBI
7	Ambrosini G, Adida C and Altieri DC: A novel anti-apoptosis gene, Survivin, expressed in cancer and lymphoma. Nat Med. 3:917–921. 1997. View Article : Google Scholar : PubMed/NCBI
8	Chiou SK, Jones MK and Tarnawski AS: Survivin an anti-apoptosis protein: its biological roles and implications for cancer and beyond. Med Sci Monit. 9:125–129. 2003.PubMed/NCBI
9	Hsu JY, Sun ZW, Li X, Reuben M, Tatchell K, Bishop DK, Grushcow JM, Brame CJ, Caldwell JA, Hunt DF, Lin R, Smith MM and Allis CD: Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. Cell. 102:279–291. 2000. View Article : Google Scholar : PubMed/NCBI
10	Ota T, Suto S, Katayama H, Han ZB, Suzuki F, Maeda M, Tanino M, Terada Y and Tatsuka M: Increased mitotic phosphorylation of histone H3 attributable to AIM-1/Aurora B overexpression contributes to chromosome number instability. Cancer Res. 62:5168–5177. 2002.PubMed/NCBI
11	Kanda A, Kawai H, Suto S, Kitajima S, Sato S, Takata T and Tatsuka M: Aurora-B/AIM-1 kinase activity is involved in Ras-mediated cell transformation. Oncogene. 24:7266–7272. 2006. View Article : Google Scholar : PubMed/NCBI
12	Honda R, Korner R and Nigg EA: Exploring the functional interactions between Aurora B, INCENP, and Survivin in mitosis. Mol Biol Cell. 14:3325–3341. 2003. View Article : Google Scholar : PubMed/NCBI
13	Beardmore VA, Ahonen LJ, Gorbsky GJ and Kallio MJ: Survivin dynamics increases at centromeres during G2/M phase transition and is regulated by microtubule-attachment and Aurora B kinase activity. J Cell Sci. 117:4033–4042. 2004. View Article : Google Scholar : PubMed/NCBI
14	Stauber RH, Mann W and Knauer SK: Nuclear and cytoplasmic Survivin: Molecular mechanism, prognostic, and therapeutic potential. Cancer Res. 67:5999–6002. 2007. View Article : Google Scholar : PubMed/NCBI
15	Knauer SK, Bier C, Habtemichael N and Stauber RH: The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function. EMBO Rep. 7:1259–1265. 2006. View Article : Google Scholar : PubMed/NCBI
16	Colnaghi R, Connell CM, Barrett RM and Wheatley SP: Separating the anti-apoptotic and mitotic roles of survivin. J Biol Chem. 281:33450–33456. 2006. View Article : Google Scholar : PubMed/NCBI
17	Tanaka K, Iwamoto S, Gon G, Nohara T, Iwamoto M and Tanigawa N: Expression of Survivin and its relationship to loss of apoptosis in breast carcinomas. Clin Cancer Res. 6:127–134. 2000.PubMed/NCBI
18	Adida C, Haioun C, Gaulard P, et al: Prognostic significance of Survivin expression in diffuse large B-cell lymphomas. Blood. 96:1921–1925. 2000.PubMed/NCBI
19	Ikeguchi M, Ueta T, Yamane Y, Hirooka Y and Kaibara N: Inducible nitric oxide synthase and Survivin messenger RNA expression in hepatocellular carcinoma. Clin Cancer Res. 8:3131–3136. 2002.PubMed/NCBI
20	Wakana Y, Kasuya K, Katayanagi S, et al: Effect of surviving on cell proliferation and apoptosis in gastric cancer. Oncol Rep. 9:1213–1218. 2002.PubMed/NCBI
21	Qi G, Tuncel H, Aoki E, Tanaka S, Oka S, Kaneko I, Okamoto M, Tatsuka M, Nakai S and Shimamoto F: Intracellular localization of survivin determines biological behavior in colorectal cancer. Oncol Rep. 22:557–562. 2009.PubMed/NCBI
22	Qi G, Kudo Y, Ando T, Siriwardena BSMS, Yoshida M, Keikahee MR, Ogawa I and Takata T: Nuclear Survivin expression is correlated with malignant behaviors of head and neck cancer together with Aurora-B. Oral Oncol. 46:263–270. 2010. View Article : Google Scholar : PubMed/NCBI