Teratoma showing the features of retinal structure: A case of sacrococcygeal teratoma

  • Authors:
    • Manabu Takamatsu
    • Hitomi Aoki
    • Yoshinobu Hirose
    • Kazuhiro Kobayashi
    • Hiroyuki Tomita
    • Toshiya Kuno
    • Hisashi Koumura
    • Akira Hara
  • View Affiliations

  • Published online on: March 6, 2012     https://doi.org/10.3892/ol.2012.636
  • Pages: 1023-1026
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Abstract

Teratoma is a tumor that forms triploblastic tissues and the common sites of occurrence are sacrococcygeal lesions and the ovaries. The majority of cases are curable with surgical resection and the prognosis depends on the extent and histological scoring of the tumor. In the present study, we report a case of sacrococcygeal teratoma of a newborn showing features of a retina-like structure. A 29-year-old woman gave birth prematurely to an infant girl with sacrococcygeal teratoma. Surgical resection was performed 10 days after delivery. The tumor contained immature components as well as a retina-like structure. Several investigations, including immunohistochemical analysis, confirmed the similarities between the normal mouse retina and the retina-like structure of the tumor. The vascular arrangement and polarity surrounding the retina-like structure are unique and this is thought to be significant in the induction of structural differentiation. Our findings may provide insights into the matter of teratogenic activity in stem cell therapies for clinical applications.
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May 2012
Volume 3 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Takamatsu M, Aoki H, Hirose Y, Kobayashi K, Tomita H, Kuno T, Koumura H and Hara A: Teratoma showing the features of retinal structure: A case of sacrococcygeal teratoma. Oncol Lett 3: 1023-1026, 2012.
APA
Takamatsu, M., Aoki, H., Hirose, Y., Kobayashi, K., Tomita, H., Kuno, T. ... Hara, A. (2012). Teratoma showing the features of retinal structure: A case of sacrococcygeal teratoma. Oncology Letters, 3, 1023-1026. https://doi.org/10.3892/ol.2012.636
MLA
Takamatsu, M., Aoki, H., Hirose, Y., Kobayashi, K., Tomita, H., Kuno, T., Koumura, H., Hara, A."Teratoma showing the features of retinal structure: A case of sacrococcygeal teratoma". Oncology Letters 3.5 (2012): 1023-1026.
Chicago
Takamatsu, M., Aoki, H., Hirose, Y., Kobayashi, K., Tomita, H., Kuno, T., Koumura, H., Hara, A."Teratoma showing the features of retinal structure: A case of sacrococcygeal teratoma". Oncology Letters 3, no. 5 (2012): 1023-1026. https://doi.org/10.3892/ol.2012.636