Teratoma showing the features of retinal structure: A case of sacrococcygeal teratoma

Takamatsu,Manabu; Aoki,Hitomi; Hirose,Yoshinobu; Kobayashi,Kazuhiro; Tomita,Hiroyuki; Kuno,Toshiya; Koumura,Hisashi; Hara,Akira

doi:10.3892/ol.2012.636

May 2012 Volume 3 Issue 5

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May 2012 Volume 3 Issue 5

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Article

Teratoma showing the features of retinal structure: A case of sacrococcygeal teratoma

Authors:
- Manabu Takamatsu
- Hitomi Aoki
- Yoshinobu Hirose
- Kazuhiro Kobayashi
- Hiroyuki Tomita
- Toshiya Kuno
- Hisashi Koumura
- Akira Hara
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Affiliations: Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan, Department of Tissue and Organ Development, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan, Department of Pediatric Surgery, Nagara Medical Center, National Hospital Organization, Gifu 502-0071, Japan
Pages: 1023-1026
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Published online on: March 6, 2012

https://doi.org/10.3892/ol.2012.636
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Abstract

Teratoma is a tumor that forms triploblastic tissues and the common sites of occurrence are sacrococcygeal lesions and the ovaries. The majority of cases are curable with surgical resection and the prognosis depends on the extent and histological scoring of the tumor. In the present study, we report a case of sacrococcygeal teratoma of a newborn showing features of a retina-like structure. A 29-year-old woman gave birth prematurely to an infant girl with sacrococcygeal teratoma. Surgical resection was performed 10 days after delivery. The tumor contained immature components as well as a retina-like structure. Several investigations, including immunohistochemical analysis, confirmed the similarities between the normal mouse retina and the retina-like structure of the tumor. The vascular arrangement and polarity surrounding the retina-like structure are unique and this is thought to be significant in the induction of structural differentiation. Our findings may provide insights into the matter of teratogenic activity in stem cell therapies for clinical applications.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Teratoma showing the features of retinal structure: A case of sacrococcygeal teratoma

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