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June 2012 Volume 3 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Arsenic trioxide enhances the cytotoxic effect of cisplatin in head and neck squamous cell carcinoma cell lines

  • Authors:
    • Ulana Kotowski
    • Gregor Heiduschka
    • Markus Brunner
    • Boban M. Erovic
    • Helga Martinek
    • Dietmar Thurnher
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, A-1090 Vienna, Austria
  • Pages: 1326-1330
    |
    Published online on: March 14, 2012
       https://doi.org/10.3892/ol.2012.643
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Abstract

Arsenic trioxide (ATO) has been approved for the treatment of relapsed acute promyelocytic leukaemia. The aim of this study was to determine whether ATO would lead to cell death in head and neck squamous cell carcinoma (HNSCC) cell lines and whether it was able to enhance the cytotoxicity of cisplatin, a standard chemotherapeutic agent. The four HNSCC cell lines SCC9, SCC25, CAL27 and FADU were treated with ATO or cisplatin alone or with ATO and cisplatin in combination. Cytotoxicity assays, immunohistochemistry, western blot analysis and flow cytometry were carried out. Possible interactions between the two drugs were calculated using the Chou-Talalay equation. Ther results demonstrated a synergistic cytotoxic effect of the combination of ATO and cisplatin at high doses. The two agents induced apoptosis in all four HNSCC cell lines. In conclusion, this study showed that ATO is a promising therapeutic drug with cytotoxic effects in HNSCC. We demonstrated a synergistic effect in the combined treatment with cisplatin at high doses.
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Copy and paste a formatted citation
Spandidos Publications style
Kotowski U, Heiduschka G, Brunner M, Erovic BM, Martinek H and Thurnher D: Arsenic trioxide enhances the cytotoxic effect of cisplatin in head and neck squamous cell carcinoma cell lines. Oncol Lett 3: 1326-1330, 2012.
APA
Kotowski, U., Heiduschka, G., Brunner, M., Erovic, B.M., Martinek, H., & Thurnher, D. (2012). Arsenic trioxide enhances the cytotoxic effect of cisplatin in head and neck squamous cell carcinoma cell lines. Oncology Letters, 3, 1326-1330. https://doi.org/10.3892/ol.2012.643
MLA
Kotowski, U., Heiduschka, G., Brunner, M., Erovic, B. M., Martinek, H., Thurnher, D."Arsenic trioxide enhances the cytotoxic effect of cisplatin in head and neck squamous cell carcinoma cell lines". Oncology Letters 3.6 (2012): 1326-1330.
Chicago
Kotowski, U., Heiduschka, G., Brunner, M., Erovic, B. M., Martinek, H., Thurnher, D."Arsenic trioxide enhances the cytotoxic effect of cisplatin in head and neck squamous cell carcinoma cell lines". Oncology Letters 3, no. 6 (2012): 1326-1330. https://doi.org/10.3892/ol.2012.643
Copy and paste a formatted citation
x
Spandidos Publications style
Kotowski U, Heiduschka G, Brunner M, Erovic BM, Martinek H and Thurnher D: Arsenic trioxide enhances the cytotoxic effect of cisplatin in head and neck squamous cell carcinoma cell lines. Oncol Lett 3: 1326-1330, 2012.
APA
Kotowski, U., Heiduschka, G., Brunner, M., Erovic, B.M., Martinek, H., & Thurnher, D. (2012). Arsenic trioxide enhances the cytotoxic effect of cisplatin in head and neck squamous cell carcinoma cell lines. Oncology Letters, 3, 1326-1330. https://doi.org/10.3892/ol.2012.643
MLA
Kotowski, U., Heiduschka, G., Brunner, M., Erovic, B. M., Martinek, H., Thurnher, D."Arsenic trioxide enhances the cytotoxic effect of cisplatin in head and neck squamous cell carcinoma cell lines". Oncology Letters 3.6 (2012): 1326-1330.
Chicago
Kotowski, U., Heiduschka, G., Brunner, M., Erovic, B. M., Martinek, H., Thurnher, D."Arsenic trioxide enhances the cytotoxic effect of cisplatin in head and neck squamous cell carcinoma cell lines". Oncology Letters 3, no. 6 (2012): 1326-1330. https://doi.org/10.3892/ol.2012.643
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