Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies

  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
June 2012 Volume 3 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June 2012 Volume 3 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Successful rechallenge with reduced dose of erlotinib in a patient with lung adenocarcinoma who developed erlotinib‑associated leukocytoclastic vasculitis: A case report

  • Authors:
    • Bo-An Su
    • Wan-Lin Shen
    • Sheng-Tsung Chang
    • Li-Yia Feng
    • Chia-Jung Wu
    • Yin-Hsun Feng

  • View Affiliations / Copyright

    Affiliations: Division of Infection, Department of Internal Medicine, Chi-Mei Medical Center, Tainan 71004, Taiwan, R.O.C., Department of Pathology, Chi-Mei Medical Center, Liouying, Tainan 73657, Taiwan, R.O.C., Department of Pathology, Chi-Mei Medical Center, Yong Kang, Tainan 71004, Taiwan, R.O.C., National Kaohsiung University of Hospitality and Tourism, Xiaogang, Kaohsiung 81271, Taiwan, R.O.C., Department of Nursing, Chi-Mei Medical Center, Liouying, Tainan 73657, Taiwan, R.O.C., Division of Hematology and Oncology, Department of Internal Medicine, Chi-Mei Medical Center, Tainan 71004, Taiwan, R.O.C.
  • Pages: 1280-1282
    |
    Published online on: March 16, 2012
       https://doi.org/10.3892/ol.2012.647
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The oral tyrosine kinase inhibitors of epidermal growth factor, erlotinib and gefitinib, are active in the treatment of non-small cell lung cancer (NSCLC). However, a number of skin manifestations have been found in patients receiving erlotinib therapy. Leukocytoclastic vasculitis is a rare side-effect of erlotinib therapy. However, whether or not erlotinib treatment should be continued when disseminated ulceration of leukocytoclastic vasculitis is encountered remains to be determined. In this study, we report a patient with NSCLC who remains responsive to erlotinib treatment following successful rechallenge with a reduced dose of erlonitib after presenting with severe degree of leukoclastic vasculitis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Ciardiello F, De Vita F, Orditura M, De Placido S and Tortora G: Epidermal growth factor receptor tyrosine kinase inhibitors in late stage clinical trials. Expert Opin Emerg Drugs. 8:501–514. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Segaert S and Van Cutsem E: Clinical signs, pathophysiology and management of skin toxicity during therapy with epidermal growth factor receptor inhibitors. Ann Oncol. 16:1425–1433. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Segaert S, Tabernero J, Chosidow O, et al: The management of skin reactions in cancer patients receiving epidermal growth factor receptor targeted therapies. J Dtsch Dermatol Ges. 3:599–606. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Carlson JA: The histological assessment of cutaneous vasculitis. Histopathology. 56:3–23. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Boeck S, Wollenberg A and Heinemann V: Leukocytoclastic vasculitis during treatment with the oral EGFR tyrosine kinase inhibitor erlotinib. Ann Oncol. 18:1582–1583. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Kubota K, Nishiwaki Y, Tamura T, et al: Efficacy and safety of erlotinib monotherapy for Japanese patients with advanced non-small cell lung cancer: a phase II study. J Thorac Oncol. 3:1439–1445. 2008. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Su B, Shen W, Chang S, Feng L, Wu C and Feng Y: Successful rechallenge with reduced dose of erlotinib in a patient with lung adenocarcinoma who developed erlotinib‑associated leukocytoclastic vasculitis: A case report. Oncol Lett 3: 1280-1282, 2012.
APA
Su, B., Shen, W., Chang, S., Feng, L., Wu, C., & Feng, Y. (2012). Successful rechallenge with reduced dose of erlotinib in a patient with lung adenocarcinoma who developed erlotinib‑associated leukocytoclastic vasculitis: A case report. Oncology Letters, 3, 1280-1282. https://doi.org/10.3892/ol.2012.647
MLA
Su, B., Shen, W., Chang, S., Feng, L., Wu, C., Feng, Y."Successful rechallenge with reduced dose of erlotinib in a patient with lung adenocarcinoma who developed erlotinib‑associated leukocytoclastic vasculitis: A case report". Oncology Letters 3.6 (2012): 1280-1282.
Chicago
Su, B., Shen, W., Chang, S., Feng, L., Wu, C., Feng, Y."Successful rechallenge with reduced dose of erlotinib in a patient with lung adenocarcinoma who developed erlotinib‑associated leukocytoclastic vasculitis: A case report". Oncology Letters 3, no. 6 (2012): 1280-1282. https://doi.org/10.3892/ol.2012.647
Copy and paste a formatted citation
x
Spandidos Publications style
Su B, Shen W, Chang S, Feng L, Wu C and Feng Y: Successful rechallenge with reduced dose of erlotinib in a patient with lung adenocarcinoma who developed erlotinib‑associated leukocytoclastic vasculitis: A case report. Oncol Lett 3: 1280-1282, 2012.
APA
Su, B., Shen, W., Chang, S., Feng, L., Wu, C., & Feng, Y. (2012). Successful rechallenge with reduced dose of erlotinib in a patient with lung adenocarcinoma who developed erlotinib‑associated leukocytoclastic vasculitis: A case report. Oncology Letters, 3, 1280-1282. https://doi.org/10.3892/ol.2012.647
MLA
Su, B., Shen, W., Chang, S., Feng, L., Wu, C., Feng, Y."Successful rechallenge with reduced dose of erlotinib in a patient with lung adenocarcinoma who developed erlotinib‑associated leukocytoclastic vasculitis: A case report". Oncology Letters 3.6 (2012): 1280-1282.
Chicago
Su, B., Shen, W., Chang, S., Feng, L., Wu, C., Feng, Y."Successful rechallenge with reduced dose of erlotinib in a patient with lung adenocarcinoma who developed erlotinib‑associated leukocytoclastic vasculitis: A case report". Oncology Letters 3, no. 6 (2012): 1280-1282. https://doi.org/10.3892/ol.2012.647
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team