Expression and prognostic significance of human peroxiredoxin isoforms in endometrial cancer

Han,Seulhee; Shen,Haiying; Jung,Minhyung; Hahn,Bum-Soo; Jin,Byung Kwan; Kang,Insug; Ha,Joohun; Choe,Wonchae

doi:10.3892/ol.2012.648

June 2012 Volume 3 Issue 6

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June 2012 Volume 3 Issue 6

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Article

Expression and prognostic significance of human peroxiredoxin isoforms in endometrial cancer

Authors:
- Seulhee Han
- Haiying Shen
- Minhyung Jung
- Bum-Soo Hahn
- Byung Kwan Jin
- Insug Kang
- Joohun Ha
- Wonchae Choe
View Affiliations / Copyright

Affiliations: Department of Biochemistry and Molecular Biology, Medical Science and Engineering Research Center for Bioreaction to Reactive Oxygen Species, Biomedical Science Institute, Seoul 130-701, Republic of Korea, Department of Obstetrics and Gynecology, Kyung Hee University School of Medicine, Seoul 130-701, Republic of Korea, National Academy of Agricultural Science, Suwon 441‑707, Republic of Korea, Neurodegeneration Control Research Center, Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 134-727, Republic of Korea
Pages: 1275-1279
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Published online on: March 16, 2012

https://doi.org/10.3892/ol.2012.648
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Abstract

Endometrial cancer is a common type of malignant tumor of the human female genital tract, which typically occurs after menopause. Asian nations, including Korea, Japan and China, have a 4-5 times lower incidence than Western industrialized nations. However, in recent years, there has been a marked increase in the incidence of the disease. Peroxiredoxin (Prx) is an antioxidant enzyme that consists of six isoforms in mammals. These enzymes share a common reactive Cys residue in the N-terminal region, and are capable of breaking down H2O2 as a peroxidase and involving thioredoxin or glutathione as the electron donor. In the present study, we evaluated the expression of Prx isoforms in normal endometrium, endometrial hyperplasia and endometrial cancer. A total of 240 patients, diagnosed with endometrial cancer by immunohistochemistry, were enrolled in this study. Results showed that Prx I, III, IV and V were negative or weakly expressed in normal endometrium, whereas levels of Prx II and VI were strongly expressed. Notably, the expression levels of Prx III and V were upregulated in endometrial cancer, compared with normal endometrium and endometrial hyperplasia. However, no differences in the staining intensities according to the grade of lesion were observed in the other Prx isoforms. The Kaplan-Meier survival analysis demonstrated that Prx V expression in endometrial cancer is significantly associated with survival rate. Therefore, we suggest that Prx V is a clinically significant prognostic marker for the development of endometrial cancer.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Expression and prognostic significance of human peroxiredoxin isoforms in endometrial cancer

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Abstract

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