Differences in the expression of five senescence markers in oral cancer, oral leukoplakia and control samples in humans

  • Authors:
    • Antonio Bascones-Martínez
    • Mercedes López-Durán
    • Jorge Cano‑Sánchez
    • Lydia Sánchez-Verde
    • Ana Díez-Rodríguez
    • Pablo Aguirre-Echebarría
    • Emilio Álvarez‑Fernández
    • Miguel Angel González-Moles
    • Jaime Bascones‑Ilundain
    • Lorenzo Lo Muzio
    • Julián Campo-Trapero
  • View Affiliations

  • Published online on: March 19, 2012     https://doi.org/10.3892/ol.2012.649
  • Pages: 1319-1325
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Abstract

Oncogene-induced senescence (OIS) may be a response to oncogenic activation, acting as a natural barrier against carcinogenesis at a premalignant stage. Thus, numerous cells in premalignant lesions enter senescence, but none or few in malignant tumours. This event could be due to the loss of senescence pathway effectors, including p16 (INK4a)-pRb or ARF-p53. The aim of this study was to characterize and compare the expression of certain senescent markers between oral precancer and cancer tissue samples. The expression of cyclin D1, Rb, maspin, p53 and mouse double minute 2 (MDM2) was analyzed in 20 paraffin-embedded tissue samples of normal oral mucosa (NOM), 14 samples of oral leukoplakia without dysplasia (OLD-), 11 samples of leukoplakia with dysplasia (OLD+) and 15 samples of oral squamous cell carcinoma (OSCC) by immunohistochemistry in tissue arrays. The expression of p16-pRb pathway markers, cyclin D1, maspin and Rb, was more frequent in OLD+ samples than in OSCC samples, although a statistical significance was only observed for maspin (P=0.036). Cyclin D1 expression was also significantly more frequent in OLD- samples vs. NOM samples. For the ARF-p53 pathway, the expression of p53 and MDM2 was significantly more frequent in the OLD- samples compared to in the NOM ones. These findings may indicate a role for cellular senescence in oral carcinogenesis, considering maspin as a reliable senescence marker and prognostic factor in oral premalignant lesions.
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June 2012
Volume 3 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Bascones-Martínez A, López-Durán M, Cano‑Sánchez J, Sánchez-Verde L, Díez-Rodríguez A, Aguirre-Echebarría P, Álvarez‑Fernández E, González-Moles MA, Bascones‑Ilundain J, Lo Muzio L, Lo Muzio L, et al: Differences in the expression of five senescence markers in oral cancer, oral leukoplakia and control samples in humans. Oncol Lett 3: 1319-1325, 2012
APA
Bascones-Martínez, A., López-Durán, M., Cano‑Sánchez, J., Sánchez-Verde, L., Díez-Rodríguez, A., Aguirre-Echebarría, P. ... Campo-Trapero, J. (2012). Differences in the expression of five senescence markers in oral cancer, oral leukoplakia and control samples in humans. Oncology Letters, 3, 1319-1325. https://doi.org/10.3892/ol.2012.649
MLA
Bascones-Martínez, A., López-Durán, M., Cano‑Sánchez, J., Sánchez-Verde, L., Díez-Rodríguez, A., Aguirre-Echebarría, P., Álvarez‑Fernández, E., González-Moles, M. A., Bascones‑Ilundain, J., Lo Muzio, L., Campo-Trapero, J."Differences in the expression of five senescence markers in oral cancer, oral leukoplakia and control samples in humans". Oncology Letters 3.6 (2012): 1319-1325.
Chicago
Bascones-Martínez, A., López-Durán, M., Cano‑Sánchez, J., Sánchez-Verde, L., Díez-Rodríguez, A., Aguirre-Echebarría, P., Álvarez‑Fernández, E., González-Moles, M. A., Bascones‑Ilundain, J., Lo Muzio, L., Campo-Trapero, J."Differences in the expression of five senescence markers in oral cancer, oral leukoplakia and control samples in humans". Oncology Letters 3, no. 6 (2012): 1319-1325. https://doi.org/10.3892/ol.2012.649