Overexpression of the B-type Eph and ephrin genes correlates with progression and pain in human pancreatic cancer

  • Authors:
    • Zhenhui Lu
    • Yong Zhang
    • Zhaoyu Li
    • Songning Yu
    • Guozhong Zhao
    • Minghao Li
    • Zuozhen Wang
    • Qi Wang
    • Yinxue Yang
  • View Affiliations

  • Published online on: March 20, 2012     https://doi.org/10.3892/ol.2012.650
  • Pages: 1207-1212
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Abstract

B-type erythropoietin-producing hepatocellular (EphB) receptors and their ephrin ligands are associated with aggressive behavior and poor prognosis in a number of malignancies. The aim of this study was to determine the association between the aberrant expression of these genes and prognosis in human pancreatic cancer. The expression of EphB and the ephrin ligands was determined using real-time quantitative reverse transcription PCR in 46 human primary pancreatic cancers. Overexpression of EphB2 and a more modest overexpression of ephrin-B2 mRNA were observed in more than 44% (20/46) of the pancreatic cancer specimens examined. Overexpression (>upper quartile) of EphB2 and ephrin-B2 was markedly associated with abdominal and/or back pain. Multivariate analysis identified the overexpression of EphB2 as an independent prognostic factor for disease-free and overall survival (both P<0.05). The results of the present study suggest that an increased level of ephrin-B2, in the presence of a high expression of EphB2, leads to a more aggressive tumor phenotype and that EphB2 may be used as a prognostic factor in human pancreatic cancer.
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June 2012
Volume 3 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Lu Z, Zhang Y, Li Z, Yu S, Zhao G, Li M, Wang Z, Wang Q and Yang Y: Overexpression of the B-type Eph and ephrin genes correlates with progression and pain in human pancreatic cancer. Oncol Lett 3: 1207-1212, 2012
APA
Lu, Z., Zhang, Y., Li, Z., Yu, S., Zhao, G., Li, M. ... Yang, Y. (2012). Overexpression of the B-type Eph and ephrin genes correlates with progression and pain in human pancreatic cancer. Oncology Letters, 3, 1207-1212. https://doi.org/10.3892/ol.2012.650
MLA
Lu, Z., Zhang, Y., Li, Z., Yu, S., Zhao, G., Li, M., Wang, Z., Wang, Q., Yang, Y."Overexpression of the B-type Eph and ephrin genes correlates with progression and pain in human pancreatic cancer". Oncology Letters 3.6 (2012): 1207-1212.
Chicago
Lu, Z., Zhang, Y., Li, Z., Yu, S., Zhao, G., Li, M., Wang, Z., Wang, Q., Yang, Y."Overexpression of the B-type Eph and ephrin genes correlates with progression and pain in human pancreatic cancer". Oncology Letters 3, no. 6 (2012): 1207-1212. https://doi.org/10.3892/ol.2012.650