Increased expression of Rab coupling protein in squamous cell carcinoma of the head and neck and its clinical significance

Dai,Yaozhang; Liu,Yong; Huang,Donghai; Yu,Changyun; Cai,Gengming; Pi,Leiming; Ren,Caiping; Chen,Georgia  Z.; Tian,Yongquan; Zhang,Xin

doi:10.3892/ol.2012.652

June 2012 Volume 3 Issue 6

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June 2012 Volume 3 Issue 6

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Article

Increased expression of Rab coupling protein in squamous cell carcinoma of the head and neck and its clinical significance

Authors:
- Yaozhang Dai
- Yong Liu
- Donghai Huang
- Changyun Yu
- Gengming Cai
- Leiming Pi
- Caiping Ren
- Georgia Z. Chen
- Yongquan Tian
- Xin Zhang
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Affiliations: Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Cancer Research Institute, Central South University, Changsha, Hunan 410008, P.R. China, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
Pages: 1231-1236
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Published online on: March 23, 2012

https://doi.org/10.3892/ol.2012.652
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Abstract

The role of Rab coupling protein (RCP) has not been previously investigated in squamous cell carcinoma of the head and neck (SCCHN). The aim of this study was to explore RCP protein expression and its clinicopathological significance in SCCHN. RCP protein expression in 95 SCCHN samples, 18 vocal nodule epithelia and 16 leukoplakia epithelia samples was analyzed by immunohistochemistry and correlated with clinicopathological parameters and patient outcome. Our data indicated that vocal nodule epithelia, leukoplakia epithelia and SCCHN showed a gradual increase in the expression of RCP protein. RCP overexpression was significantly associated with T classification, clinical staging, lymph node metastasis and recurrence. Survival analysis revealed that a high RCP expression was significantly correlated with shorter overall survival and disease-free survival. In conclusion, RCP protein may contribute to the malignant progression of SCCHN, and serves as a novel prognostic marker in patients with SCCHN.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Increased expression of Rab coupling protein in squamous cell carcinoma of the head and neck and its clinical significance

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