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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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June 2012 Volume 3 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

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Case Report

Oxaliplatin-induced acute-onset thrombocytopenia and hemorrhage: Case report and review of the literature

  • Authors:
    • Shoichiro Ohta
    • Yukiko Cho
    • Shinji Oshima
    • Osamu Hosoya
    • Kazuhiko Juni
    • Hiroshi Kojima

  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Ibaraki Prefectural Central Hospital, Ibaraki, Japan, Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan
  • Pages: 1297-1300
    |
    Published online on: March 23, 2012
       https://doi.org/10.3892/ol.2012.653
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Abstract

We report the case of a woman who developed acute thrombocytopenia with hemorrhagic diathesis during adjuvant treatment of colorectal adenocarcinoma with oxaliplatin, 5-fluorouracil and leucovorin. A 55-year-old woman started adjuvant chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin (mFOLFOX6). Prior to starting the 12th course of chemotherapy, a complete blood cell count showed the following values: neutrophils 1800/mm3, platelets 136,000/­m3 and hemoglobin 11.1 g/dl. A blood count revealed that the platelet levels had dropped to 35,000/mm3, with no significant changes in hemoglobin levels following the course. The admini­stration of corticosteroids was begun and the platelet number was recovered. Clinicians should be aware of the possibility of oxaliplatin-induced hematological emergencies during the treatment of colorectal cancer patients in order to optimize supportive treatment and avoid toxic mortality.
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Copy and paste a formatted citation
Spandidos Publications style
Ohta S, Cho Y, Oshima S, Hosoya O, Juni K and Kojima H: Oxaliplatin-induced acute-onset thrombocytopenia and hemorrhage: Case report and review of the literature. Oncol Lett 3: 1297-1300, 2012.
APA
Ohta, S., Cho, Y., Oshima, S., Hosoya, O., Juni, K., & Kojima, H. (2012). Oxaliplatin-induced acute-onset thrombocytopenia and hemorrhage: Case report and review of the literature. Oncology Letters, 3, 1297-1300. https://doi.org/10.3892/ol.2012.653
MLA
Ohta, S., Cho, Y., Oshima, S., Hosoya, O., Juni, K., Kojima, H."Oxaliplatin-induced acute-onset thrombocytopenia and hemorrhage: Case report and review of the literature". Oncology Letters 3.6 (2012): 1297-1300.
Chicago
Ohta, S., Cho, Y., Oshima, S., Hosoya, O., Juni, K., Kojima, H."Oxaliplatin-induced acute-onset thrombocytopenia and hemorrhage: Case report and review of the literature". Oncology Letters 3, no. 6 (2012): 1297-1300. https://doi.org/10.3892/ol.2012.653
Copy and paste a formatted citation
x
Spandidos Publications style
Ohta S, Cho Y, Oshima S, Hosoya O, Juni K and Kojima H: Oxaliplatin-induced acute-onset thrombocytopenia and hemorrhage: Case report and review of the literature. Oncol Lett 3: 1297-1300, 2012.
APA
Ohta, S., Cho, Y., Oshima, S., Hosoya, O., Juni, K., & Kojima, H. (2012). Oxaliplatin-induced acute-onset thrombocytopenia and hemorrhage: Case report and review of the literature. Oncology Letters, 3, 1297-1300. https://doi.org/10.3892/ol.2012.653
MLA
Ohta, S., Cho, Y., Oshima, S., Hosoya, O., Juni, K., Kojima, H."Oxaliplatin-induced acute-onset thrombocytopenia and hemorrhage: Case report and review of the literature". Oncology Letters 3.6 (2012): 1297-1300.
Chicago
Ohta, S., Cho, Y., Oshima, S., Hosoya, O., Juni, K., Kojima, H."Oxaliplatin-induced acute-onset thrombocytopenia and hemorrhage: Case report and review of the literature". Oncology Letters 3, no. 6 (2012): 1297-1300. https://doi.org/10.3892/ol.2012.653
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