A case of metastatic haemangiopericytoma to the thyroid gland: Case report and literature review

Proietti,Agnese; Sartori,Chiara; Torregrossa,Liborio; Vitti,Paolo; Aghababyan,Aleksandr; Fregoli,Lorenzo; Miccoli,Paolo; Basolo,Fulvio

doi:10.3892/ol.2012.661

June 2012 Volume 3 Issue 6

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June 2012 Volume 3 Issue 6

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Case Report

A case of metastatic haemangiopericytoma to the thyroid gland: Case report and literature review

Authors:
- Agnese Proietti
- Chiara Sartori
- Liborio Torregrossa
- Paolo Vitti
- Aleksandr Aghababyan
- Lorenzo Fregoli
- Paolo Miccoli
- Fulvio Basolo
View Affiliations / Copyright

Affiliations: Division of Pathology, Department of Surgery, University of Pisa, I-56126 Pisa, Italy, Department of Endocrinology, University of Pisa, I-56124 Pisa, Italy, Division of Surgery, Department of Surgery, University of Pisa, I-56124 Pisa, Italy
Pages: 1255-1258
|
Published online on: March 29, 2012

https://doi.org/10.3892/ol.2012.661
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Abstract

Haemangiopericytoma (HPC) is a mesenchymal neoplasm accounting for a minority of all vascular tumours. HPC mostly arises in the lower extremities and the retroperitoneum, while the head and neck area is the third most common site. The majority of HPCs are histologically benign. However, a small percentage possess atypical features, such as a high mitotic rate, high cellularity and foci of necrosis. We report a case of classical abdominal HPC that presented 7 years after the first surgical resection with thyroid metastases of malignant HPC. Microscopic examination revealed multiple hypercellular nodules with an infiltrative growth pattern. These nodules consisted of tightly packed fusiform or spindle-shaped cells with nuclear polymorphism and an increased mitotic rate. The tumour cells exhibited a marked expression of CD34. Cells were arranged around a prominent vascular network, occasionally with a ‘staghorn’ configuration. The results of this study support and confirm the theory that HPC is a rare neoplasm with unpredictable behaviour, as largely debated in the international literature. Therefore, this study emphasized the importance of applying strict diagnostic criteria in making the most appropriate diagnosis.

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1	Stout AP and Murray MR: Hemangiopericytoma: a vascular tumor featuring Zimmermann’s pericytes. Ann Surg. 116:26–33. 1942.PubMed/NCBI
2	Enzinger FM and Weiss SW: Soft Tissue Tumors. 5th edition. Mosby; New York, NY: 2008
3	Gengler C and Guillou L: Solitary fibrous tumour and haemangiopericytoma: evolution of a concept. Histopathology. 48:63–74. 2006. View Article : Google Scholar : PubMed/NCBI
4	Enzinger FM and Weiss SW: Soft Tissue Tumors. 3rd edition. Mosby; New York, NY: 1995
5	Espat NJ, Lewis JJ, Leung D, Woodruff JM, Antonescu CR, Shia J and Brennan MF: Conventional hemangiopericytoma. Cancer. 95:1746–1751. 2002. View Article : Google Scholar : PubMed/NCBI
6	Benn JJ, Firth RG and Sönksen PH: Metabolic effect of an insulin-like factor causing hypoglycemia in a patient with haemangiopericytoma. Clin Endocrinol. 32:769–780. 1990. View Article : Google Scholar : PubMed/NCBI
7	Enzinger FM and Smith BH: Hemangiopericytoma. An analysis of 106 cases Hum Pathol. 7:61–82. 1976.
8	Spitz FR, Bouvet M, Pisters PW, Pollock RE and Feig BW: Hemangiopericytoma: a 20-year single-institution experience. Ann Surg Oncol. 5:350–355. 1998.PubMed/NCBI
9	Brandwein MS, Kapadia SB and Gnepp DR: Nonsquamous pathology of the larynx, hypopharynx, and trachea. Diagnostic Surgical Pathology of the Head and Neck. Gnepp DR: Saunders; Philadelphia, PA: pp. 304–305. 2001
10	Weis SW and Goldblum JR: Soft Tissue Tumors. Mosby; St Louis: 2001
11	Prokš C: Generalized hemangiopericytoma of the thyroid gland (report of a case). Neoplasma. 8:219–224. 1961.PubMed/NCBI
12	Tano Assini MT, Oliva Otero G and Gomez SC: Visceral hemangiopericytoma. Presentation of 2 cases. Prensa Med Argent. 55:996–1000. 1968.PubMed/NCBI
13	Kallenberg F and Anagnostaki L: Hemangiopericytoma of the thyroid gland. Ugeskr Laeger. 141:3530–3531. 1979.PubMed/NCBI
14	Tytor M and Olofsson J: Thyroid tumors invading the larynx and trachea. J Otolaryngol. 15:74–79. 1986.PubMed/NCBI
15	Justrabo E, Michiels JF, Maire J, Jacquot JP and Levillain P: Hemangiopericytoma of the thyroid gland. Ann Endocrinol (Paris). 50:26–30. 1989.
16	Geisinger KR, Silverman JF, Cappellari JO and Dabbs DJ: Fine-needle aspiration cytology of malignant hemangiopericytomas with ultrastructural and flow cytometric analyses. Arch Pathol Lab Med. 114:705–710. 1990.PubMed/NCBI
17	Dictor M, Elner A, Andersson T and Fernö M: Myofibromatosis- like hemangiopericytoma metastasizing as differentiated vascular smooth-muscle and myosarcoma. Myopericytes as a subset of ‘myofibroblasts’. Am J Surg Pathol. 16:1239–1247. 1992.PubMed/NCBI
18	Cameselle-Teijeiro J, Manuel Lopes J, Villanueva JP, Gil-Gil P and Sobrinho-Simões M: Lipomatous haemangiopericytoma (adipocytic variant of solitary fibrous tumour) of the thyroid. Histopathology. 43:406–408. 2003. View Article : Google Scholar : PubMed/NCBI
19	Hansen T, Gaumann A, Ghalibafian M, Höferlin A, Heintz A and Kirkpatrick CJ: Haemangiopericytoma of the thyroid gland in combination with Hashimoto’s disease. Virchows Arch. 445:315–319. 2004.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

A case of metastatic haemangiopericytoma to the thyroid gland: Case report and literature review

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Abstract

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