Ethylenediaminetetraacetic acid‑dependent pseudothrombocytopenia associated with neuroendocrine carcinoma: A case report

Kim,Hee Jun; Moh,In Ho; Yoo,Hana; Son,Seungyeon; Jung,Da Hye; Lee,Hun Gu; Han,Dong Hee; Park,Jae Hyun; Kim,Hyeong Su; Kim,Jung Han

doi:10.3892/ol.2012.675

July 2012 Volume 4 Issue 1

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July 2012 Volume 4 Issue 1

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Case Report

Ethylenediaminetetraacetic acid‑dependent pseudothrombocytopenia associated with neuroendocrine carcinoma: A case report

Authors:
- Hee Jun Kim
- In Ho Moh
- Hana Yoo
- Seungyeon Son
- Da Hye Jung
- Hun Gu Lee
- Dong Hee Han
- Jae Hyun Park
- Hyeong Su Kim
- Jung Han Kim
View Affiliations / Copyright

Affiliations: Department of Internal Medicine, Hallym Medical Center, Hallym University College of Medicine, Seoul 150-950, Republic of Korea
Pages: 86-88
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Published online on: April 11, 2012

https://doi.org/10.3892/ol.2012.675
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Abstract

Ethylenediaminetetraacetic acid-dependent pseudothrombocytopenia (EDTA-PTCP) is an in vitro phenomenon of EDTA-induced platelet aggregation at room temperature. This phenomenon consists of platelet clumping due to anti-platelet antibodies in blood anticoagulated with EDTA. It has been reported in patients with various diseases, including sepsis, multiple myeloma, acute myocardial infarction and breast cancer. Since unrecognized EDTA-PTCP may lead to inappropriate treatment, it should always be considered as a possible cause in patients with low platelet counts. This study identified a case of transient EDTA-PTCP in a patient with neuroendocrine carcinoma of the stomach. In the present study, a 50-year-old male presented with epigastric pain and a weight loss of 15 kg. The patient presented with EDTA-PTCP and was diagnosed with neuroendocrine carcinoma of the stomach. Following systemic chemotherapy, the tumor showed a marked regression and the EDTA-PTCP disappeared. The mechanism by which this occurred is not clear but an association of EDTA-PTCP with neuroendocrine carcinoma is strongly suggested.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Ethylenediaminetetraacetic acid‑dependent pseudothrombocytopenia associated with neuroendocrine carcinoma: A case report

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