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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article

Expression and mutation of the c-kit gene and correlation with prognosis of small cell lung cancer

  • Authors:
    • Hong-Yang Lu
    • Gu Zhang
    • Qiao-Yuan Cheng
    • Bo Chen
    • Ju-Fen Cai
    • Xiao-Jia Wang
    • Yi-Ping Zhang
    • Zeng Wang
    • Zhen-Yi Lu
    • Fa-Jun Xie
    • Wei-Min Mao
  • View Affiliations / Copyright

    Affiliations: Zhejiang Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology (Esophagus, Lung), Zhejiang Province, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China, Department of Pathology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China, Department of Traditional Chinese Medicine, Zhejiang Institute for Food and Drug Control, Hangzhou, Zhejiang 310004, P.R. China, Department of Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China, Department of Pharmacology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China, Xiangshan First People's Hospital, Xiangshan, Zhejiang 315700, P.R. China
  • Pages: 89-93
    |
    Published online on: April 12, 2012
       https://doi.org/10.3892/ol.2012.679
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Abstract

Small cell lung cancer (SCLC) is a highly aggressive and lethal type of cancer in humans. SCLC is sensitive to chemotherapy and radiotherapy, but long-term survival is low and the majority of patients eventually develop progressive disease. With the success of imatinib mesylate in the treatment of gastrointestinal stromal tumors expressing c-kit, its use in SCLC serves as a novel molecular therapeutic approach. The activity of imatinib mesylate is correlated with the mutation of c-kit gene exons 9 and 11 in gastrointestinal stromal tumors. The incidence of epidermal growth factor receptor mutation in non-small cell lung cancer is higher in China than in the United States of America and European countries. There may be also differences in the incidence of c-kit mutation between China and European countries. At present, no study examining imatinib mesylate treatment for SCLC in China is available. To investigate the expression and mutation of c-kit and the correlation with prognosis of SCLC in China, immuno­histochemistry was used to detect the expression of c-kit, and a pyrosequencing assay was used to detect mutations in c-kit exons 9 and 11 of 36 SCLC patients who received surgical treatment at the Zhejiang Cancer Hospital, Hangzhou, China, between 1998 and 2010. All 36 patients were followed up to analyze the correlation between prognosis and expression and mutation of c-kit. The incidence of c-kit-positive expression was 83.3%, including 25.0% weak staining, 22.2% moderate staining and 36.1% strong staining. The overall survival of patients with c-kit strong staining was shorter compared to patients with c-kit not strong staining. No mutation in c-kit exons 9 and 11 was detected. In conclusion, the findings showed that the expression of c-kit is high, and strong staining is a prognostic factor for worse survival.
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Copy and paste a formatted citation
Spandidos Publications style
Lu H, Zhang G, Cheng Q, Chen B, Cai J, Wang X, Zhang Y, Wang Z, Lu Z, Xie F, Xie F, et al: Expression and mutation of the c-kit gene and correlation with prognosis of small cell lung cancer. Oncol Lett 4: 89-93, 2012.
APA
Lu, H., Zhang, G., Cheng, Q., Chen, B., Cai, J., Wang, X. ... Mao, W. (2012). Expression and mutation of the c-kit gene and correlation with prognosis of small cell lung cancer. Oncology Letters, 4, 89-93. https://doi.org/10.3892/ol.2012.679
MLA
Lu, H., Zhang, G., Cheng, Q., Chen, B., Cai, J., Wang, X., Zhang, Y., Wang, Z., Lu, Z., Xie, F., Mao, W."Expression and mutation of the c-kit gene and correlation with prognosis of small cell lung cancer". Oncology Letters 4.1 (2012): 89-93.
Chicago
Lu, H., Zhang, G., Cheng, Q., Chen, B., Cai, J., Wang, X., Zhang, Y., Wang, Z., Lu, Z., Xie, F., Mao, W."Expression and mutation of the c-kit gene and correlation with prognosis of small cell lung cancer". Oncology Letters 4, no. 1 (2012): 89-93. https://doi.org/10.3892/ol.2012.679
Copy and paste a formatted citation
x
Spandidos Publications style
Lu H, Zhang G, Cheng Q, Chen B, Cai J, Wang X, Zhang Y, Wang Z, Lu Z, Xie F, Xie F, et al: Expression and mutation of the c-kit gene and correlation with prognosis of small cell lung cancer. Oncol Lett 4: 89-93, 2012.
APA
Lu, H., Zhang, G., Cheng, Q., Chen, B., Cai, J., Wang, X. ... Mao, W. (2012). Expression and mutation of the c-kit gene and correlation with prognosis of small cell lung cancer. Oncology Letters, 4, 89-93. https://doi.org/10.3892/ol.2012.679
MLA
Lu, H., Zhang, G., Cheng, Q., Chen, B., Cai, J., Wang, X., Zhang, Y., Wang, Z., Lu, Z., Xie, F., Mao, W."Expression and mutation of the c-kit gene and correlation with prognosis of small cell lung cancer". Oncology Letters 4.1 (2012): 89-93.
Chicago
Lu, H., Zhang, G., Cheng, Q., Chen, B., Cai, J., Wang, X., Zhang, Y., Wang, Z., Lu, Z., Xie, F., Mao, W."Expression and mutation of the c-kit gene and correlation with prognosis of small cell lung cancer". Oncology Letters 4, no. 1 (2012): 89-93. https://doi.org/10.3892/ol.2012.679
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